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Regional Myocardial Perfusion Assessed by Nitrogen-13 Labeled Ammonia and Positron Emission Computerized Axial Tomography

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Frontiers in Nuclear Medicine

Abstract

With the recent development of positron emission computerized axial tomography (PCT), cross-sectional imaging of the heart has become possible [1]. These cross-sectional images reflect quantitatively the distribution of radioactive indicator concentrations in the myocardium and can be thought of as “in vivo” autoradiographs. Potentially, PCT provides a nontraumatic means for quantifying regional myocardial perfusion. The usefulness of 13NH3 as a myocardial perfusion imaging agent suitable for PCT has been suggested [2–5], although the relation of 13NH3 uptake to myocardial blood flow has not yet been examined in quantitative terms. Characterization of this relationship including the study of myocardial 13NH3 uptake during the hyperemia of exercise is particularly important for the noninvasive assessment of coronary artery disease [6,7]. Therefore, the goal of this study was to examine the realtionship between myocardial perfusion and 13NH3 uptake over a wide range of coronary blood flow and to examine the accuracy of quantifying noninvasively by PCT myocardial 13NH3 tissue concentration and, hence, regional myocardial perfusion.

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Author information

Authors and Affiliations

  1. Division of Nuclear Medicine, UCLA School of Medicine, Los Angeles, California, 90024, USA

    H. R. Schelbert, M. E. Phelps, E. J. Hoffman & S.-C. Huang

  2. Laboratory of Nuclear Medicine and Radiation Biology, Los Angeles, California, USA

    H. R. Schelbert, M. E. Phelps, E. J. Hoffman & S.-C. Huang

Authors
  1. H. R. Schelbert
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  2. M. E. Phelps
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  3. E. J. Hoffman
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  4. S.-C. Huang
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Editor information

Editors and Affiliations

  1. Universitätsklinik und Poliklinik für Radioonkologie und Nuklearmedizin, Rämistraße 100, 8006, Zürich, Switzerland

    Wolfgang Horst

  2. Division of Nuclear Medicine, John Hopkins Medical Center, 615 North Wolfe Street, 212005, Baltimore, Maryland, USA

    Henry N. Wagner Jr.

  3. Division of Nuclear Medicine, John Hopkins Medical Institutions, 615 North Wolfe Street, 212005, Baltimore, Maryland, USA

    Julia W. Buchanan

  4. Division of Radiation Health, John Hopkins Medical Institutions, 615 North Wolfe Street, 212005, Baltimore, Maryland, USA

    Julia W. Buchanan

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© 1980 Springer-Verlag Berlin Heidelberg

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Schelbert, H.R., Phelps, M.E., Hoffman, E.J., Huang, SC. (1980). Regional Myocardial Perfusion Assessed by Nitrogen-13 Labeled Ammonia and Positron Emission Computerized Axial Tomography. In: Horst, W., Wagner, H.N., Buchanan, J.W. (eds) Frontiers in Nuclear Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67575-1_3

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  • DOI: https://doi.org/10.1007/978-3-642-67575-1_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09895-9

  • Online ISBN: 978-3-642-67575-1

  • eBook Packages: Springer Book Archive

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