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Genetics of Immunological Diseases pp 268–275Cite as

The Effect of the nude Gene on Plasmacytoma Development in BALB/cAn Mice

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 137))

Abstract

The role of the T-lymphocyte in the development of plasma cell tumors may be investigated by attempting to induce these tumors in mice that lack a mature T-cell population. The nude mutation in mice is a recessive gene and homozygous mice (nu/nu) lack both a thymus (Pantelouris, 1968) and a hair coat (Flanagan, 1966). The absence of functional thymus glands in nu/nu mice results in a severe deficiency of mature T-lymphocytes throughout life (Scheid, et al. 1975; Chen et al. 1984). Consequently, these mice have defective immune responses which involve T-lymphocytes and have commonly been used to demonstrate the role of T-lymphocytes in a variety of immune responses (Eckels, et al., 1979; Jacobson, et al., 1974; Kindred, 1978). A congenic strain with the nu gene on the BALB/cAn background, the BALB/cAn•nu/nu, was utilized to determine whether nude mice would develop plasmacytomas (PCTs) and if so, at what incidence. In addition, we determined whether the BALB/cAn • nu/nu was genetically identical (with the possible exception of genes flanking the nude mutation on chromosome 11) to the BALB/cAnPt subline which is commonly used in PCT induction experiments.

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Authors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institues of Health, Bethesda, Maryland, USA

    L. Byrd, M. Potter, B. Mock & K. Huppi

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  1. L. Byrd
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  2. M. Potter
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  3. B. Mock
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  4. K. Huppi
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    Beverly Mock Ph.D  & Michael Potter M.D.  & 

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© 1988 Springer-Verlag Berlin · Heidelberg

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Byrd, L., Potter, M., Mock, B., Huppi, K. (1988). The Effect of the nude Gene on Plasmacytoma Development in BALB/cAn Mice. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_41

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  • DOI: https://doi.org/10.1007/978-3-642-50059-6_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-50061-9

  • Online ISBN: 978-3-642-50059-6

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