Abstract
Afr-1 is a genetic locus in mice that controls the adult level of serum alpha-fetoprotein. Under normal circumstances, AFP synthesis is repressed shortly after birth, from levels approaching 10 million nanograms/milliliter to adult levels of only several hundred ng/ml (Olsson et al., 1977) . In the special case of BALB/cJ mice however, this down-regulation of AFP synthesis is ten- to twenty-fold less efficient, resulting in circulating AFP levels of several thousand ng/ml in 15-week old mice (Olsson et al., 1977) . The recessive allele of Afr-1 responsible for this persistance of AFP (Afr-1b) is found only in BALB/c mice of the Jackson substrain, and not in any other mouse tested to date (Blankenhorn et al., 1985) .
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References
Belayew A, Tilghman SM (1982) Genetic analysis of alphafetoprotein synthesis in mice. Mol Cell Biol 2: 1427 – 1435
Blankenhorn EP, Wax, JS, Matthai, R, Potter, M (1985) Genetic analysis of alphafetoprotein levels in BALB/c sublines. Curr Top Micro Immunol 122:53–57
Kozak LP, Berkenmeier EH (1983) Mouse sn-glycerol-3-phosphate dehydrogenase: Molecular cloning and genetic mapping of a cDNA sequence. Proc Natl Acad Sci (USA) 80: 3020–3024
Kozak LP (1985) Genetic variation of catecholamine responsive metabolic pathways — a hypothesis for a common regulatory mechanism in BALB/c sublines. Curr Top Micro Immunol 122: 66–70
LeClair KP, Rabin M, Nesbitt MN, Pratcheva D, Ruddle FH, Palfree RGE, Bothwell A (1987) Murine Ly-6 multigene family is located on chromosome 15. Proc Natl Acad Sci (USA) 84: 1638–1642
McKusick VA (1986) The Human Gene Map. Clin Gen 29:545–588
Meruelo D, Rossomando A, Scandalis S, DfEustachio P, Fournier REK, Roop DR, Saxe D, Blatt C, Nesbitt MN (1987) Assignment of the Ly-6--Ril-1--Sis--H3O --Pol5/Xmnv-72--Ins3--Krt-1--Int-1--Gdc-1 region to mouse chromosome 15. Immunogenetics 25: 361–372
Murgita RA, Tomasi TB (1975) Suppression of immune response by alphafetoprotein. J Exp Med 141:440–452
O’Brien SJ Genetic Maps 1987. Cold Spring Harbor Laboratory.
Olsson M, Lindahl G, Ruoslahti E (1977) Genetic control of alphafetoprotein synthesis in the mouse. J Exp Med 145: 819–827
Pollard DR, Woodward B, Gupta K (1982) Strain and sex differences in serum alpha-fetoprotein levels in Mus musculus. Can J Genet Cytol 24: 343–346
Teuscher C, Potter M, Tung KSK (1985) Differential susceptibility to experimental autoimmune orchitis in BALB/c substrains. Curr Top Micro Immunol 122: 181–188
Vogt TF, Solter D, Tilghman SM (1987) Raf, a trans-acting locus, regulates the alpha-fetoprotein gene in a cell-autonomous manner. Science 236: 301–303.
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© 1988 Springer-Verlag Berlin · Heidelberg
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Blankenhorn, E.P., Duncan, R., Teuscher, C., Potter, M. (1988). Genetic Map Location of Afr-1: Results From Four Genetic Crosses. In: Mock, B., Potter, M. (eds) Genetics of Immunological Diseases. Current Topics in Microbiology and Immunology, vol 137. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-50059-6_40
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DOI: https://doi.org/10.1007/978-3-642-50059-6_40
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