Zusammenfassung
Das Ziel der Antikoagulation ist die Vermeidung von Thrombenbildung im extrakorporalen Kreislauf ohne eine unerwünschte Blutungsneigung auszulösen. Zum Einsatz kommen bei der chronischen Dialysebehandlung am häufigsten die in Tab. 4.1 aufgeführten Antikoagulanzien.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsLiteratur
Bates SM, Weitz JI (2006) The status of new anticoagulants. Br J Haematol 134(1):3–19
Canaud B, Bragg-Gresham JL, Marshall MR, Desmeules S, Gillespie BW, Depner T, Klassen P, Port FK (2006) Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS. Kidney Int 69(11):2087–2093
Collignon F, Frydman A, Caplain H, Ozoux ML, Le Roux Y, Bouthier J, Thébault JJ (1995) Comparison of the pharmacokinetic profiles of three low molecular mass heparins-dalteparin, enoxaparin and nadroparin-administered subcutaneously in healthy volunteers (doses for prevention of thromboembolism). Thromb Haemost. 73(4):630–640
Eichler P, Friesen HJ, Lubenow N, Jaeger B, Greinacher A (2000) Antihirudin antibodies in patients with heparin-induced thrombocytopenia treated with lepirudin: incidence, effects on aPTT, and clinical relevance. Blood 96(7):2373–2378
Gordon LA, Perkins HA, Richards V et al. (1956) Studies in regional heparinization. II. Artificial-kidney hemodialysis without systemic heparinization; preliminary report of a method using simultaneous infusion of heparin and protamine. N Engl J Med; 255:1063
Greinacher A, Lubenow N (2003) Heparin-Induced Thrombocytopenia. Orphanet Encyclopedia. December
Hammerstingl C, Omran H Nickenig G (2009) Peri-operatives Bridging einer oralen Antikoagulation bei Patienten mit chronischer Niereninsuffizienz, Journal für Kardiologie 2009; 16 (7–8), 290–294
Hetzel GR, Sucker C (2005) The heparins: all a nephrologist should know, Nephrol Dial Transplant 20: 2036–2042
Hemodialyzer Membranes (2007) Implications for Clinical Use. Clin J Am Soc Nephrol 2: 470–476
Hirsh J, Raschke R (2004) Heparin and low-molecular-weight heparin: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest, 126(3 Suppl):188S–203S
Hirsh J, Anand SS, Halperin JL, Fuster V (2001) Guide to anticoagulant therapy: heparin: a statement for healthcare professionals from the American Heart Association. Circulation; 103:2994
Janssen MJ, Deegens JK, Kapinga TH, Beukhof JR, Huijgens PC, van Loenen AC, van der Meulen J (1996) Citrate compared to low molecular weight heparin anticoagulation in chronic hemodialysis patients. Kidney Int 49(3):806–813
Kiser TH, Fish DN (2006) Evaluation of bivalirudin treatment for heparin-induced thrombocytopenia in critically ill patients with hepatic and/or renal dysfunction. Pharmacotherapy, 26(4):452–460
Lewis BE, Wallis DE, Berkowitz SD et al. (2001) Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 103: 1838–1843
Lo GK, Juhl D, Warkentin TE, Sigouin CS, Eichler P, Greinacher A (2006) Evaluation of pretest clinical score (4 T‘s) for the diagnosis of heparin-induced thrombocytopenia in two clinical settings. J Thrombosis and Haemostasis 4: 759–765
Mahnel R, Bassus S, Kirchmaier CM (2009) Blutungskomplikationen unter Antikoagulanzien-Therapie, Internist, 50:1369–1380
Martel N, Lee J, Wells PS (2005) Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis. Blood 106(8):2710–5. Epub 2005 Jun 28
Mureebe L, Coats RD, Silliman WR, Shuster TA, Nichols WK, Silver D (2004) Heparin-associated antiplatelet antibodies increase morbidity and mortality in hemodialysis patients. Surgery, 136: 848–853
Nadel S, Goldstein B et al. (2007) Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet. 369(9564):836–843
Nutescu EA, Shapiro NL, Chevalier A, Amin AN (2005) A pharmacologic overview of current and emerging anticoagulants. Cleve Clin J Med. 72 Suppl 1:S2–6
Nutescu EA, Shapiro NL, Chevalier A (2008) New anticoagulant agents: direct thrombin inhibitors. Cardiol Clin. 26(2):169–87, v–vi
O’Donnell MJ et al. (2007) Brief communication: Preoperative anticoagulant activity after bridging low-molecular-weight heparin for temporary interruption of warfarin. Ann Intern Med; 146:184–187
Ota K, Kawaguchi H, Takahashi K, Ito K (1983) A new prostacyclin analog – An anticoagulant applicable to hemodialysis. Trans Am Soc Artif Intern Organs, 29:419
Sagedal S, Hartmann A, Sundstrøm K, Bjørnsen S, Fauchald P, Brosstad F (1999) A single dose of dalteparin effectively prevents clotting during haemodialysis Nephrol. Dial. Transplant. 14: 1943–1947
Swartz RD, Flamenbaum W, Dubrow A, Hall JC, Crow JW, Cato A (1988) Epoprostenol (PGI2, prostacyclin) during high-risk hemodialysis: preventing further bleeding complications. J Clin Pharmacol, 28(9):818–825
Teien AN, Bjoornson J (1976) Heparin elimination in uraemic patients on Haemodialysis. Scand J Haematol. 17(1):29–35
Uchino S, Bellomo R, Morimatsu H et al. (2007) Continuous renal replacement therapy: a worldwide practice survey. The beginning and ending supportive therapy for the kidney (B.E.S.T. kidney) investigators. Intensive Care Med., 33(9):1563–1570
Warren HS, Suffedini AF et al. (2002) Risks and benefits of activated protein C treatment for severe sepsis. N Engl J Med. 26;347(13):1027–1030
Warkentin TE, Greinacher A, Koster A, Lincoff AM (2008) Treatment and prevention of heparin-induced thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest 133:340S
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Geberth, S., Nowack, R. (2014). Antikoagulation. In: Praxis der Dialyse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-41208-0_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-41208-0_4
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-41207-3
Online ISBN: 978-3-642-41208-0
eBook Packages: Medicine (German Language)