Skip to main content

Volumenmanagement, enterale Ernährung und Schmerztherapie bei akuter Pankreatitis

  • Chapter
  • First Online:
Book cover Erkrankungen des Pankreas
  • 3826 Accesses

Zusammenfassung

Patienten mit sowohl milder als auch schwerer akuter Pankreatitis haben einen deutlich gesteigerten Flüssigkeitsbedarf, der durch isotone Vollelektrolytlösungen (Ringer) ausgeglichen werden sollte. Prognostisch entscheidend ist die Volumengabe innerhalb der ersten 24 Stunden, wobei bei Herzgesunden zwischen 2500 und 4000 ml Kristalloide infundiert werden sollten. Eine frühenterale Ernährung ist eine wesentliche Komponente der Therapie bei akuter Pankreatitis und ist bei allen Schweregraden sinnvoll, sofern keine Kontraindikationen vorliegen. Durch eine überbrückende parenterale Zusatzernährung kann eine vollkalorische Bilanz erreicht werden. Bei der Schmerztherapie der akuten Pankreatitis empfiehlt sich ähnlich dem WHO-Stufenschema der Tumorschmerztherapie eine gestaffelte Gabe von Schmerztherapeutika, wobei mit NSAID begonnen werden kann. Wenn die alleinige Gabe von Nicht-Opioiden nicht ausreicht, sollten mittelstark bzw. stark wirkende Opioid-Analgetika eingesetzt werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Abou-Assi S, Craig K et al (2002) Hypocaloric jejunal feeding is better than total parenteral nutrition in acute pancreatitis: results of a randomized comparative study. Am J Gastroenterol 97(9): 2255–2262

    Article  PubMed  Google Scholar 

  • AWMF (2007) S3-Leitlinie Ernährungsmedizin: Parenterale Ernährung. Akt Ernähr Med 32: 3–6

    Article  Google Scholar 

  • Baillargeon JD, Orav J et al (1998) Hemoconcentration as an early risk factor for necrotizing pancreatitis. Am J Gastroenterol 93(11): 2130–2134

    Article  PubMed  CAS  Google Scholar 

  • Bernhardt A, Kortgen A et al (2002) [Using epidural anesthesia in patients with acute pancreatitis – prospective study of 121 patients]. Anaesthesiol Reanim 27(1): 16–22

    PubMed  CAS  Google Scholar 

  • Brown A, Baillargeon JD et al (2002) Can fluid resuscitation prevent pancreatic necrosis in severe acute pancreatitis? Pancreatology 2(2): 104–107

    Article  PubMed  CAS  Google Scholar 

  • Brunkhorst FM, Engel C et al (2008) Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 358(2): 125–139

    Article  PubMed  CAS  Google Scholar 

  • Coelho AM, Jukemura J et al (2010) Mechanisms of the beneficial effect of hypertonic saline solution in acute pancreatitis. Shock 34(5): 502–507

    Article  PubMed  Google Scholar 

  • Coelho JC, Senninger N et al (1986) Effect of analgesic drugs on the electromyographic activity of the gastrointestinal tract and sphincter of Oddi and on biliary pressure. Ann Surg 204(1): 53–58

    Article  PubMed  CAS  Google Scholar 

  • de-Madaria E, Soler-Sala G et al (2011) Influence of fluid therapy on the prognosis of acute pancreatitis: a prospective cohort study. Am J Gastroenterol 106(10): 1843–1850

    Article  PubMed  Google Scholar 

  • Der Arzneimittelbrief 1999; 33: 89

    Google Scholar 

  • Dominguez-Munoz J (2005) Clinical pancreatology for practising gastroenterologists and surgeons. Blackwell Publishing

    Google Scholar 

  • Eatock FC, Chong P et al (2005) A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 100(2): 432–439

    Article  PubMed  CAS  Google Scholar 

  • Economou G, Ward-McQuaid JN (1971) A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure. Gut 12(3): 218–221

    Article  PubMed  CAS  Google Scholar 

  • Forsmark CE, Baillie J (2007) AGA Institute technical review on acute pancreatitis. Gastroenterology 132(5): 2022–2044

    Article  PubMed  CAS  Google Scholar 

  • Gardner TB, Vege SS et al (2009) Faster rate of initial fluid resuscitation in severe acute pancreatitis diminishes in-hospital mortality. Pancreatology 9(6): 770–776

    Article  PubMed  Google Scholar 

  • Huber W, Umgelter A et al (2008) Volume assessment in patients with necrotizing pancreatitis: a comparison of intrathoracic blood volume index, central venous pressure, and hematocrit, and their correlation to cardiac index and extravascular lung water index. Crit Care Med 36(8): 2348–2354

    Article  PubMed  Google Scholar 

  • Jakobs R, Adamek MU et al (2000) Buprenorphine or procaine for pain relief in acute pancreatitis. A prospective randomized study. Scand J Gastroenterol 35(12): 1319–1323

    Article  PubMed  CAS  Google Scholar 

  • Kahl S, Zimmermann S et al (2004) Procaine hydrochloride fails to relieve pain in patients with acute pancreatitis. Digestion 69(1): 5–9

    Article  PubMed  Google Scholar 

  • Kalfarentzos F, Kehagias J et al (1997) Enteral nutrition is superior to parenteral nutrition in severe acute pancreatitis: results of a randomized prospective trial. Br J Surg 84(12): 1665–1669

    Article  PubMed  CAS  Google Scholar 

  • Kumar A, Singh N et al (2006) Early enteral nutrition in severe acute pancreatitis: a prospective randomized controlled trial comparing nasojejunal and nasogastric routes. J Clin Gastroenterol 40(5): 431–434

    Article  PubMed  CAS  Google Scholar 

  • Lankisch PG, Weber-Dany B et al (2010) High serum creatinine in acute pancreatitis: a marker for pancreatic necrosis? Am J Gastroenterol 105(5): 1196–1200

    Article  PubMed  CAS  Google Scholar 

  • Layer P, Bronisch HJ et al (2011) Effects of systemic administration of a local anesthetic on pain in acute pancreatitis: a randomized clinical trial. Pancreas 40(5): 673–679

    Article  PubMed  CAS  Google Scholar 

  • Lerch MM (2004) No more intravenous procaine for pancreatitis pain? Digestion 69(1): 2–4

    Article  PubMed  Google Scholar 

  • Mao EQ, Fei J et al (2010) Rapid hemodilution is associated with increased sepsis and mortality among patients with severe acute pancreatitis. Chin Med J (Engl) 123(13): 1639–1644

    CAS  Google Scholar 

  • Mao EQ, Tang YQ et al (2009) Fluid therapy for severe acute pancreatitis in acute response stage. Chin Med J (Engl) 122(2): 169–173

    Google Scholar 

  • Marik PE, Zaloga GP (2004) Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis. BMJ 328(7453): 1407

    Article  PubMed  Google Scholar 

  • Marino P (2008) Das ICU-Buch. Praktische Intensivmedizin, 4. Aufl. Urban & Fischer, München

    Google Scholar 

  • Mayerle J, Hlouschek V et al (2005) Current management of acute pancreatitis. Nat Clin Pract Gastroenterol Hepatol 2(10): 473–483

    Article  PubMed  Google Scholar 

  • Mossner J, Teich N (2008) [Nutrition in acute pancreatitis]. Z Gastroenterol 46(8): 784–789

    Article  PubMed  CAS  Google Scholar 

  • Peiro AM, Martinez J et al (2008) Efficacy and tolerance of metamizole versus morphine for acute pancreatitis pain. Pancreatology 8(1): 25–29

    Article  PubMed  CAS  Google Scholar 

  • Perner A, Haase N et al (2012) Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med 367(2): 124–134

    Article  PubMed  CAS  Google Scholar 

  • Petrov MS, Whelan K (2010) Comparison of complications attributable to enteral and parenteral nutrition in predicted severe acute pancreatitis: a systematic review and meta-analysis. Br J Nutr 103(9): 1287–1295

    Article  PubMed  CAS  Google Scholar 

  • Salomone T, Tosi P et al (2003) Coagulative disorders in human acute pancreatitis: role for the D-dimer. Pancreas 26(2): 111–116

    Article  PubMed  CAS  Google Scholar 

  • Spiegel B (2001) Meperidine or morphine in acute pancreatitis? Am Fam Physician 64(2): 219–220

    PubMed  CAS  Google Scholar 

  • Teich N, Aghdassi A et al (2010) Optimal timing of oral refeeding in mild acute pancreatitis: results of an open randomized multicenter trial. Pancreas 39(7): 1088–1092

    Article  PubMed  Google Scholar 

  • Trikudanathan G, Navaneethan U et al (2012) Current controversies in fluid resuscitation in acute pancreatitis: a systematic review. Pancreas 41(6): 827–834

    Article  PubMed  Google Scholar 

  • Wada K, Takada T et al (2010) Treatment strategy for acute pancreatitis. J Hepatobiliary Pancreat Sci 17(1): 79–86

    Article  PubMed  Google Scholar 

  • Warndorf MG, Kurtzman JT et al (2011) Early fluid resuscitation reduces morbidity among patients with acute pancreatitis. Clin Gastroenterol Hepatol 9(8): 705–709

    Article  PubMed  Google Scholar 

  • Windsor AC, Kanwar S et al (1998) Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis. Gut 42(3): 431–435

    Article  PubMed  CAS  Google Scholar 

  • Wu BU, Hwang JQ et al (2011) Lactated Ringer’s solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 9(8): 710–717 e1

    Article  PubMed  Google Scholar 

  • Wu BU, Johannes RS et al (2009) Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology 137(1): 129–135

    Article  PubMed  CAS  Google Scholar 

  • Yang R, Uchiyama T et al (2004) Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis. Crit Care Med 32(7): 1453–1459

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ali A. Aghdassi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Aghdassi, A., Mayerle, J. (2013). Volumenmanagement, enterale Ernährung und Schmerztherapie bei akuter Pankreatitis. In: Beger, H., et al. Erkrankungen des Pankreas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37964-2_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-37964-2_6

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-37963-5

  • Online ISBN: 978-3-642-37964-2

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics