Definition
Photothermal therapy (PTT) is a method of heat ablation in which light energy is utilized to induce localized heat within the tissue and destroy the pathologic cells. Often in practice and in order to not harm surrounding healthy tissues, the targeted diseased cells are labeled with light-absorbing nano-sized particles, which significantly increases the light energy absorption and also allows for utilizing laser lights in near-infrared (NIR) wavelengths to achieve larger penetration depths. With the aid of these nano-sized agents (i.e., nanoparticles), PTT is capable of destroying pathologic cells selectively, at larger penetration depth and with no damage to surrounding non-labeled healthy tissue.
Characteristics
Hyperthermia is a noninvasive approach for cancertherapy, whereby biological tissues are exposed to higher than normal temperatures to promote destruction of abnormal cells. PTT is...
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References
Chen F, Cai W (2015) Nanomedicine for targeted photothermal cancer therapy: where are we now? Nanomedicine 10:1–3
Chen CH, Wu Y-J, Chen J-J (2015) Gold nanotheranostics: photothermal therapy and imaging of Mucin 7 conjugated antibody nanoparticles for urothelial cancer. Biomed Research International, Article ID 813632
Goodrich GP, Payne JD, Sharp K, Bao L, Sang KL (2009) Efficacy of photothermal ablation using intravenously delivered NIR-absorbing nanorods in colon cancer. SPIE BiOS: Biomed Opt 7181:71810Q–71810Q-5
Huang X, Jain PK, El-Sayed IH, El-Sayed MA (2008) Plasmonic photothermal therapy (PPTT) using gold nanoparticles. Lasers Med Sci 23:217–228
Jabeen F, Najam-ul-Haq M, Javeed R, Huck CW, Bonn GK (2014) Au-Nanomaterials as a Superior Choice for Near-Infrared Photothermal Therapy. Molecules 19(12):20580–20593
Melamed JR, Edelstein RS, Day ES (2015) Elucidating the fundamental mechanisms of cell death triggered by photothermal therapy. ACS Nano 9:6–11
Nadejda R, JinZhong Z (2009) Photothermal ablation therapy for cancer based on metal nanostructures. Science in China Series B: Chemistry 52:1559–1575
Schwartz JA, Shetty AM, Price RE, Stafford RJ, Wang JC, Uthamanthil RK, Pham K, McNichols RJ Coleman CL, Payne JD (2009) Feasibility study of particle-assisted laser ablation of brain tumors in orthotopic. Cancer Res. 69(4):1659–1667
Wang S, Dai Z, Ke H, Qu E, Qi X, Zhang K et al (2013) Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer. Eur J Radiol 177–122
Welch AJ (1984) The thermal response of laser irradiated tissue. IEEE J Quantum Electron 20:1471–1481
Zezell DM, Ana PA (2015) High power lasers and their interaction with biological tissues. Lasers in dentistry: guide for clinical practice. Joh Wiely & Sons, Inc, Hobken, NJ, pp 11–18
See Also
(2008) Tumor. In: Rédei GP (ed) Encyclopedia of genetics, genomics, proteomics and informatics, 3rd edn. Springer, The Netherlands, p 2045. doi:10.1007/978-1-4020-6754-9_17595
(2012) Plasma membrane. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2900. doi:10.1007/978-3-642-16483-5_4599
Bechmann I (2006) Brain. In: Ganten D (ed) Encyclopedic reference of genomics and proteomics in molecular medicine. Springer, Berlin/Heidelberg, pp 166–173. doi:10.1007/3-540-29623-9_5620
Computer Science and Communications Dictionary (2001) Near infrared. Springer-Verlag US, New York, p 1076. doi:10.1007/1-4020-0613-6_12129
Goldstein B (2011) Chemotherapy. In: Kreutzer JS, DeLuca J, Caplan B (eds) Encyclopedia of clinical neuropsychology. Springer, New York, pp 544–546. doi:10.1007/978-0-387-79948-3_98
Huth BJ (2013) Colon cancer. In: Brady LW, Yaeger TE (eds) Encyclopedia of radiation oncology. Springer, Berlin/Heidelberg, pp 126–131. doi:10.1007/978-3-540-85516-3_72
Kreidberg J (2009) Animal models. In: Avner E, Harmon W, Niaudet P, Yoshikawa N (eds) Pediatric nephrology. Springer, Berlin/Heidelberg, pp 397–417. doi:10.1007/978-3-540-76341-3_16
Moll R (2006) Breast cancer. In: Ganten D (ed) Encyclopedic reference of genomics and proteomics in molecular medicine. Springer, Berlin/Heidelberg, pp 174–180. doi:10.1007/3-540-29623-9_4360
Schleicher Pliska E (2015) Cancer. In: Loue S, Sajatovic M (eds) Encyclopedia of immigrant health. Springer, New York, pp 340–344. doi:10.1007/978-1-4419-5659-0_112
Sheriff A, Herrmann M, Voll RE, Gaipl US, Kalden JR (2006) Inflammatory response. In: Encyclopedic reference of genomics and proteomics in molecular medicine. Springer, Berlin/Heidelberg, pp 877–882. doi:10.1007/3-540-29623-9_4580
Tadros T (2013) Nanoparticle. In: Tadros T (ed) Encyclopedia of colloid and interface science. Springer, Berlin/Heidelberg, pp 747–748. doi:10.1007/978-3-642-20665-8_121
Weiss C, Roedel C (2013) Bladder. In: Brady LW, Yaeger TE (eds) Encyclopedia of radiation oncology. Springer, Berlin/Heidelberg, pp 29–40. doi:10.1007/978-3-540-85516-3_108
Wong E (2011) Ablation. In: Kreutzer JS, DeLuca J, Caplan B (eds) Encyclopedia of clinical neuropsychology. Springer, New York, p 6. doi:10.1007/978-0-387-79948-3_3
Yu S, Sousa N, Almeida OFX (2014) Apoptosis. In: Stolerman IP, Price LH (eds) Encyclopedia of psychopharmacology. Springer, Berlin/Heidelberg, pp 1–12. doi:10.1007/978-3-642-27772-6_385-2
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Gellci, K., Mehrmohammadi, M. (2014). Photothermal Therapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_7097-1
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DOI: https://doi.org/10.1007/978-3-642-27841-9_7097-1
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