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Textbook of Aging Skin pp 1–13Cite as

DNA Damage and Repair in Skin Aging

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Abstract

Skin aging reflects the accumulation of damage to DNA from both internal and environmental sources. While solar UV induces the most frequent modifications of DNA, air pollution and tobacco smoke have also been demonstrated to induce the cascade of repair responses triggered by DNA damage. Cells use complexes of proteins to remove or reverse DNA damage, but if the lesions are not repaired, a sequence of proteins is activated that invokes wound-healing reactions or cell death. If these reactions are not sufficient to control the DNA damage, the skin risks immunosuppression, destruction of the collagen support structure, and even cancer. Genetic mutations in DNA repair genes can cause hereditary cancer diseases, while simple polymorphisms in some DNA repair genes in apparently healthy people may also predispose them to cancer. Methods to defend against DNA damage include melanin, sunscreens, antioxidants, and administration of DNA repair enzymes.

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Author information

Authors and Affiliations

  1. The Estee Lauder Companies, Inc., Melville, NY, USA

    Daniel B. Yarosh

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  1. Daniel B. Yarosh
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Correspondence to Daniel B. Yarosh .

Editor information

Editors and Affiliations

  1. Procter & Gamble Co., Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Procter & Gamble Co., Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department Dermatology, University of California, San Francisco School of Medicine, San Francisco, California, USA

    Howard I. Maibach

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Yarosh, D.B. (2015). DNA Damage and Repair in Skin Aging. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27814-3_31-2

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  • DOI: https://doi.org/10.1007/978-3-642-27814-3_31-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27814-3

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  1. Latest

    DNA Damage and Repair in Skin Aging
    Published:
    27 April 2016

    DOI: https://doi.org/10.1007/978-3-642-27814-3_31-3

  2. Original

    DNA Damage and Repair in Skin Aging
    Published:
    14 July 2015

    DOI: https://doi.org/10.1007/978-3-642-27814-3_31-2

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