Abstract
Bisulfite sequencing is a technique that can be combined with next-generation sequencing approaches to analyze DNA methylation patterns in a genome wide scale. The GATK framework is a new Java framework for fast-developing NGS applications including capabilities for automatic shared-memory parallelization. This work presents the design and initial performance results of a methylation caller for next-generation bisultife sequencing based on the GATK framework.
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Glez-Peña, D., Graña, O., Fdez-Riverola, F., Pisano, D.G. (2011). Building a GATK-Based Tool for Methylation Analysis in Next-Generation Bisulfite Sequencing Experiments. In: Rocha, M.P., Rodríguez, J.M.C., Fdez-Riverola, F., Valencia, A. (eds) 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2011). Advances in Intelligent and Soft Computing, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19914-1_13
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DOI: https://doi.org/10.1007/978-3-642-19914-1_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19913-4
Online ISBN: 978-3-642-19914-1
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