Abstract
The patient, a 16-year-old male, who was a previously healthy high school athlete, was admitted to the intensive care unit via the emergency department (ED) with a four day history of fever, chills, and occasional rigor, myalgia, and productive cough, now with increasing dyspnea and hemoptysis over the past 24 hours. His temperature was 38.1°C, blood pressure was 133/87 mm Hg, pulse 104 beats per minute, and his respiratory rate 16 per minute. He was well developed and well nourished, but in respiratory distress, with tachycardia and coarse rhonchi bilaterally at the bases of both lungs. Six weeks prior to presentation, the patient was hospitalized for knee surgery due to an injury he sustained in a North American basketball tournament. At the time of surgery the patient was screened for methicillin-resistant Staphylococcus aureus (MRSA) with an FDA-approved MRSA polymerase chain reaction (PCR) assay, as part of a hospital-wide active surveillance program, aimed at prevention of hospital transmission of infections. At that time, the surveillance test result was reported as “MRSA Detected.” There was no personal or family history of diabetes mellitus and no immunosuppression. The patient denied HIV risk factors and denied the use of illicit drugs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Klevens RM, Morrison MA, Nadle J et al (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:1763–1771
Edwards JR, Peterson KD, Andrus ML et al (2007) National Healthcare Safety Network (NHSN) report, data summary for 2006, issued June 2007. Am J Infect Control 35:290–301
Cosgrove SE, Qi Y, Kaye KS et al (2005) The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 26:166–174
Jacobus CH, Lindsell CJ, Leach SD et al (2007) Prevalence and demographics of methicillin resistant Staphylococcus aureus in culturable skin and soft tissue infections in an urban emergency department. BMC Emerg Med 7:19
Carroll KC (2008) Rapid diagnostics for methicillin-resistant Staphylococcus aureus: current status. Mol Diagn Ther 12:15–24
van Trijp MJ, Melles DC, Hendriks WD et al (2007) Successful control of widespread methicillin-resistant Staphylococcus aureus colonization and infection in a large teaching hospital in the Netherlands. Infect Control Hosp Epidemiol 28:970–975
Robicsek A, Beaumont JL, Paule SM et al (2008) Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Ann Intern Med 148:409–418
Diekema DJ, Edmond MB (2007) Look before you leap: active surveillance for multidrug-resistant organisms. Clin Infect Dis 44:1101–1107
Araj GF, Talhouk RS, Simaan CJ et al (1999) Discrepancies between mecA PCR and conventional tests used for detection of methicillin resistant Staphylococcus aureus. Int J Antimicrob Agents 11:47–52
Wolk DM, Marx JL, Dominguez L et al (2009) Comparison of MRSA Select agar, CHROMagar Methicillin-Resistant Staphylococcus aureus (MRSA) Medium, and Xpert MRSA PCR for detection of MRSA in Nares: diagnostic accuracy for surveillance samples with various bacterial densities. J Clin Microbiol 47:3933–3936
Wolk DM, Picton E, Johnson D et al (2009) Multicenter evaluation of the Cepheid Xpert methicillin-resistant Staphylococcus aureus (MRSA) test as a rapid screening method for detection of MRSA in nares. J Clin Microbiol 47:758–764
Donnio PY, Oliveira DC, Faria NA et al (2005) Partial excision of the chromosomal cassette containing the methicillin resistance determinant results in methicillin-susceptible Staphylococcus aureus. J Clin Microbiol 43:4191–4193
Francois P, Bento M, Renzi G et al (2007) Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus. J Clin Microbiol 45:2011–2013
Anonymous (2007) Xpert MRSA Package Insert. 300–5188, Rev. C
Harrington AT, Mahlen SD, Clarridge JE III (2010) Significantly larger numbers of methicillin-resistant Staphylococcus aureus bacteria are recovered from polymicrobial respiratory and wound sites by use of chromogenic primary media than by use of conventional culture. J Clin Microbiol 48:1350–1353
Kipp F, Kahl BC, Becker K et al (2005) Evaluation of two chromogenic agar media for recovery and identification of Staphylococcus aureus small-colony variants. J Clin Microbiol 43:1956–1959
Jones EM, Bowker KE, Cooke R et al (1997) Salt tolerance of EMRSA-16 and its effect on the sensitivity of screening cultures. J Hosp Infect 35:59–62
2007 Severe methicillin-resistant Staphylococcus aureus community-acquired pneumonia associated with influenza-Louisiana and Georgia, December 2006–January 2007. MMWR Morb Mortal Wkly Rep 56: 325–329. mm5614a1 [pii]
Mandell LA, Wunderink RG, Anzueto A et al (2007) Infectious diseases society of America/American thoracic society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 44(Suppl 2):S27–S72
Gupta RK, George R, Nguyen-Van-Tam JS (2008) Bacterial pneumonia and pandemic influenza planning. Emerg Infect Dis 14:1187–1192
Finelli L, Fiore A, Dhara R et al (2008) Influenza-associated pediatric mortality in the United States: increase of Staphylococcus aureus coinfection. Pediatrics 122:805–811
Muto CA, Jernigan JA, Ostrowsky BE et al (2003) SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol 24:362–386
McKibben L, Horan T, Tokars JI et al (2005) Guidance on public reporting of healthcare-associated infections: recommendations of the healthcare infection control practices advisory committee. Am J Infect Control 33:217–226
Siegel JD, Rhinehart E, Jackson M et al (2007) Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control 35:S165–S193
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Wolk, D.M. (2011). MRSA. In: Schrijver, I. (eds) Diagnostic Molecular Pathology in Practice. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19677-5_35
Download citation
DOI: https://doi.org/10.1007/978-3-642-19677-5_35
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19676-8
Online ISBN: 978-3-642-19677-5
eBook Packages: MedicineMedicine (R0)