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Targeting Retroviral and Lentiviral Vectors

  • Chapter
Cellular Factors Involved in Early Steps of Retroviral Replication

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 281))

Abstract

Retroviral vectors capable of efficient in vivo gene delivery to specific target cell types or to specific locations of disease pathology would greatly facilitate many gene therapy applications. The surface glycoproteins of membrane-enveloped viruses stand among the choice candidates to control the target cell receptor recognition and host range of retroviral vectors onto which they are incorporated. This can be achieved in many ways, such as the exchange of glycoprotein by pseudotyping, their biochemical modifications, their conjugation with viruscell bridging agents or their structural modifications. Understanding the fundamental properties of the viral glycoproteins and the molecular mechanism of virus entry into cells has been instrumental in the functional alteration of their tropism. Here we briefly review the current state of our understanding of the structure and function of viral envelope glycoproteins and we discuss the emerging targeting strategies based on retroviral and lentiviral vector systems.

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  1. Laboratoire de Vectorologie Rétrovirale et Thérapie Génique, Unité de Virologie Humaine, INSERM U412, Ecole Normale Supérieure de Lyon, 46 allée d’Italie, 69364, Lyon Cedex 07, France

    V. Sandrin & F.-L. Cosset

  2. Molecular Medicine Program, Guggenheim 18, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    S. J. Russell

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  1. Department of Oncology McArdle Laboratory for Cancer Research, University Wisconsin, Madison, 1400 University Avenue, Madison, WI, 53706, USA

    John A. T. Young (The Howard M. Temin, Professor in Cancer Research) (The Howard M. Temin, Professor in Cancer Research)

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Sandrin, V., Russell, S.J., Cosset, FL. (2003). Targeting Retroviral and Lentiviral Vectors. In: Young, J.A.T. (eds) Cellular Factors Involved in Early Steps of Retroviral Replication. Current Topics in Microbiology and Immunology, vol 281. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19012-4_4

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