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Serine-Threonine Kinase Receptor-Associated Protein

  • Reference work entry
  • First Online:
Encyclopedia of Cancer

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Synonyms

hMAWD: Human MAPK activator with WD repeats; STRAP; Unrip: unr-interacting protein

Definition

STRAP is a 39 kDa protein of WD-40 family involved in probable chaperoning function during the formation of multiprotein complexes shown to be active in the transforming growth factor-β (TGF-β) receptor signaling network and U-rich small nuclear ribonucleoprotein (U snRNP) assembly. Oncogenic STRAP is upregulated in human cancers and may be involved in tumor progression.

Characteristics

STRAP was first cloned from mouse embryonic cDNA library while searching for novel proteins that bind the cytoplasmic region of TGF-β type I receptor (TβRI) using yeast two-hybrid screening. Later, it was found that STRAP could associate with both type I and type II (TβRII) serine-threonine kinase receptors. Southern blot analyses demonstrate that STRAP is evolutionarily conserved from yeast to mammals. The importance of this conservation was revealed when STRAP knockout mice were generated using the...

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References

  1. Buess M, Terracciano L, Reuter J et al (2004) STRAP is a strong predictive marker of adjuvant chemotherapy benefit in colorectal cancer. Neoplasia 6(6):813–820

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  2. Datta P, Chytil A, Gorska A et al (1998) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem 273(52):34671–34674

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  3. Datta P, Moses H (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol 20(9):3157–3167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Halder S, Anumanthan G, Maddula R et al (2006) Oncogenic function of a novel WD-domain protein, STRAP, in human carcinogenesis. Cancer Res 66(12):6156–6166

    Article  CAS  PubMed  Google Scholar 

  5. Seong H, Jung H, Choi H et al (2005) Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein. J Biol Chem 280(52):42897–42908

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Departments of Surgery and Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA

    Nilesh D. Kashikar & Pran K. Datta

Authors
  1. Nilesh D. Kashikar
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  2. Pran K. Datta
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Corresponding author

Correspondence to Nilesh D. Kashikar .

Editor information

Editors and Affiliations

  1. University Professor of Genetics, German Cancer Research Center - DKFZ, Heidelberg, Germany

    Manfred Schwab

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© 2011 Springer-Verlag Berlin Heidelberg

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Kashikar, N.D., Datta, P.K. (2011). Serine-Threonine Kinase Receptor-Associated Protein. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_5259

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