Definition
Named after the criteria formulated by Ross Prentice in an influential 1989 article on validation of surrogate endpoints, were developed to ensure that rejection of the null hypothesis under the surrogate endpoint implies rejection of the null hypothesis under the true endpoint. The main criterion, sometimes called the Prentice criterion, is that the distribution of the true endpoint conditional on the surrogate endpoint does not depend on the intervention. In other words, the Prentice criterion says that, for all treatments under consideration, there is a single pathway from treatment to true endpoint that goes through the surrogate endpoint, so once the surrogate endpoint is known, no other information is needed to determine the distribution of the true endpoint.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Prentice Criteria. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_4725
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DOI: https://doi.org/10.1007/978-3-642-16483-5_4725
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Publisher Name: Springer, Berlin, Heidelberg
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Online ISBN: 978-3-642-16483-5
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