Definition
PTM is the chemical modifications of proteins following their translations. After syntheses, the proteins are subjected to reversible or permanent modifications. They are one of the later steps in protein biosyntheses for many proteins. To identify the specific sites of modifications in the analysis of enzymatically digested proteins, tandem mass spectrometry with collision-induced dissociation of peptides can be used. More than 300 PTMs have been identified, such as phosphorylation, glycosylation, ubiquitination, deamidation, proteolytic processing, fatty acylation, and glycosylphosphatidylinositol lipid anchor attachment. Analysis of a protein for PTMs is very important for understanding issues such as activity, stability, interaction, and turnover.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). Posttranslational Modification. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_4696
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DOI: https://doi.org/10.1007/978-3-642-16483-5_4696
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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