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Elongation factor 2 kinase

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Springer Handbook of Enzymes

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References

  1. Ryazanov, A.G.; Ward, M.D.; Mendola, C.E.; Pavur, K.S.; Dorovkov, M.V.; Wiedmann, M.; Erdjument-Bromage, H.; Tempst, P.; Parmer, T.G.; Prostko, C.R.; Germino, F.J.; Hait, W.N.: Identification of a new class of protein kinases represented by eukaryotic elongation factor-2 kinase. Proc. Natl. Acad. Sci. USA, 94, 4884–4889 (1997)

    Article  PubMed  CAS  Google Scholar 

  2. Redpath, N.T.; Price, N.T.; Proud, C.G.: Cloning and expression of cDNA encoding protein synthesis elongation factor-2 kinase. J. Biol. Chem., 271, 17547–17554 (1996)

    Article  PubMed  CAS  Google Scholar 

  3. Sans, M.D.; Xie, Q.; Williams, J.A.: Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini. Biochem. Biophys. Res. Commun., 319, 144–151 (2004)

    Article  PubMed  CAS  Google Scholar 

  4. Arora, S.; Yang, J.M.; Kinzy, T.G.; Utsumi, R.; Okamoto, T.; Kitayama, T.; Ortiz, P.A.; Hait, W.N.: Identification and characterization of an inhibitor of eukaryotic elongation factor 2 kinase against human cancer cell lines. Cancer Res., 63, 6894–6899 (2003)

    PubMed  CAS  Google Scholar 

  5. Arora, S.; Yang, J.M.; Hait, W.N.: Identification of the ubiquitin-proteasome pathway in the regulation of the stability of eukaryotic elongation factor-2 kinase. Cancer Res., 65, 3806–3810 (2005)

    Article  PubMed  CAS  Google Scholar 

  6. Ren, H.; Tai, S.K.; Khuri, F.; Chu, Z.; Mao, L.: Farnesyltransferase inhibitor SCH66336 induces rapid phosphorylation of eukaryotic translation elongation factor 2 in head and neck squamous cell carcinoma cells. Cancer Res., 65, 5841–5847 (2005)

    Article  PubMed  CAS  Google Scholar 

  7. Gutzkow, K.B.; Lahne, H.U.; Naderi, S.; Torgersen, K.M.; Skalhegg, B.; Koketsu, M.; Uehara, Y.; Blomhoff, H.K.: Cyclic AMP inhibits translation of cyclin D3 in T lymphocytes at the level of elongation by inducing eEF2-phosphorylation. Cell. Signal., 15, 871–881 (2003)

    Article  PubMed  CAS  Google Scholar 

  8. Browne, G.J.; Finn, S.G.; Proud, C.G.: Stimulation of the AMP-activated protein kinase leads to activation of eukaryotic elongation factor 2 kinase and to its phosphorylation at a novel site, serine 398. J. Biol. Chem., 279, 12220–12231 (2004)

    Article  PubMed  CAS  Google Scholar 

  9. Stattlegger, E.; Hinnebusch, A.G.: Polyribosome binding by GCN1 is required for full activation of eukaryotic translation initiation factor 2{α} kinase GCN2 during amino acid starvation. J. Biol. Chem., 280, 16514–16521 (2005)

    Article  Google Scholar 

  10. Carroll, M.; Warren, O.; Fan, X.; Sossin, W.S.: 5-HT stimulates eEF2 dephosphorylation in a rapamycin-sensitive manner in Aplysia neurites. J. Neurochem., 90, 1464–1476 (2004)

    Article  PubMed  CAS  Google Scholar 

  11. Rose, A.J.; Broholm, C.; Kiillerich, K.; Finn, S.G.; Proud, C.G.; Rider, M.H.; Richter, E.A.; Kiens, B.: Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men. J. Physiol., 569, 223–228 (2005)

    Article  PubMed  CAS  Google Scholar 

  12. Browne, G.J.; Proud, C.G.: A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol. Cell. Biol., 24, 2986–2997 (2004)

    Article  PubMed  CAS  Google Scholar 

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(2009). Elongation factor 2 kinase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol S4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85701-3_4

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