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Atomic Force Microscopy Studies of the Mechanical Properties of Living Cells

  • Chapter
Book cover Applied Scanning Probe Methods IX

Part of the book series: Nano Science and Technolgy ((NANO))

Abstract

The study of viscoelastic and adhesive properties of cells falls under the discipline of cellular mechanics. Our knowledge of cell mechanics has been limited until the development of tools that allow us to measure minute forces (piconewton) and small dimensions (nanometer) at the cellular level. The atomic force microscope (AFM) is a very useful tool for determining the mechanical properties of cells as it allows experiments to be conducted under physiological conditions. The focus of this review is to provide an overview of the AFM as a tool for measuring the mechanical (viscoelastic and adhesive) properties of living cells. First, the differentmodes of operation of the AFM are briefly introduced, drawing special attention to the force mode. Then, the methods used to determine the viscoelasticity of cells are described, followed by a review of the available methods for determining cell adhesion at both single-molecule and whole-cell levels.

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Authors and Affiliations

  1. Department of Physiology & Biophysics, University of Miami, 1600 NW 12th Ave, RMSB 5077, 33136, Miami, FL, USA

    Félix Rico, Ewa P. Wojocikiewicz & Vincent T. Moy

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  1. Félix Rico
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  2. Ewa P. Wojocikiewicz
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  3. Vincent T. Moy
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Editor information

Editors and Affiliations

  1. Advanced Institute of Science & Technology, School of Materials Science, 923-1292, Ishikawa, Japan

    Masahiko Tomitori

  2. Nanotribology Laboratory for Information Storage and MEMS/NEMS (NLIM), The Ohio State University, W390 Scott Laboratory, 201W. 19th Avenue, 43210-1142, Columbus, Ohio, USA

    Bharat Bhushan

  3. Institute of Physics, FB 16, University of Münster, Wilhelm-Klemm-Str. 10, 48149, Münster, Germany

    Harald Fuchs

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Rico, F., Wojocikiewicz, E., Moy, V. (2008). Atomic Force Microscopy Studies of the Mechanical Properties of Living Cells. In: Tomitori, M., Bhushan, B., Fuchs, H. (eds) Applied Scanning Probe Methods IX. Nano Science and Technolgy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74083-4_4

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