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Apoptosis-Inducing Proteins in Chicken Anemia Virus and TT Virus

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TT Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 331))

Abstract

Torque teno viruses (TTVs) share several genomic similarities with the chicken anemia virus (CAV). CAV encodes the protein apoptin that specifically induces apoptosis in (human) tumor cells. Functional studies reveal that apoptin induces apoptosis in a very broad range of (human) tumor cells. A putative TTV open reading frame (ORF) in TTV genotype 1, named TTV apoptosis inducing protein (TAIP), it induces, like apoptin, p53-independent apoptosis in various human hepato-carcinoma cell lines to a similar level as apoptin. In comparison to apoptin, TAIP action is less pronounced in several analyzed human non-hepatocarcinoma-derived cell lines. Detailed sequence analysis has revealed that the TAIP ORF is conserved within a limited group of the heterogeneous TTV population. However, its N-terminal half, N-TAIP, is rather well conserved in a much broader set of TTV isolates. The similarities between apoptin and TAIP, and their relevance for the development and treatment of diseases is discussed.

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Authors and Affiliations

  1. Department of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands

    M. H. de Smit & M. H. M. Noteborn

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  1. M. H. de Smit
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  2. M. H. M. Noteborn
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Correspondence to M. H. de Smit or M. H. M. Noteborn .

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Editors and Affiliations

  1. Deutsches Krebsforschungszentrum Abt., Tumorvirus-Charakterisierung, Im Neuenheimer Feld 242, Heidelberg, 69120, Germany

    Ethel-Michele de Villiers

  2. Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany

    Harald zur Hausen

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de Smit, M.H., Noteborn, M.H.M. (2009). Apoptosis-Inducing Proteins in Chicken Anemia Virus and TT Virus. In: de Villiers, EM., Hausen, H.z. (eds) TT Viruses. Current Topics in Microbiology and Immunology, vol 331. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70972-5_9

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