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Patient Alignment and Target Tracking in Radiosurgery of Soft-Tissue Tumors Using Combined Fiducial and Skeletal Structures Tracking Techniques

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Treating Tumors that Move with Respiration

Abstract

When using the CyberKnife® (Accuray Incorporated, Sunnyvale, CA) Image-Guided Stereotactic Radiosurgery (SRS) System to treat soft-tissue tumors in anatomic sites other than intracranial or spinal locations — such as in the lung, liver, kidney, prostate, and pancreas — fiducial placement in or close to the tumors is necessary to assist patient alignment and target tracking for precise treatment delivery. Under the assumption of rigid transformation, at least three fiducial markers are required to obtain six-degreesof-freedom transformation parameters, i.e., three translations and three rotations. However, in most cases, soft tissue is highly deformable and non-rigid. This results in three possible scenarios: 1) the rigid body criteria fail and the rotational transformation cannot be obtained, 2) the tumor deformation results in unreliable computed rotational information, and 3) even when the fiducial array meets the rigid body criteria, the orientation of the tumor often has poor correlation with the global body orientation and thus results in dosimetric deviation.

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Authors and Affiliations

  1. Division of Medical Physics Department of Radiation Oncology, University of Miami Leonard M. Miller School of Medicine, 1475 NW 12 Ave, Miami, FL, 33136, USA

    Xiaodong Wu PhD, DABR (Associate Professor and Chief), Alberto de la Zerda PhD, DABR (Assistant Professor), Elizabeth Bossart PhD, DABR (Assistant Professor), Hua Shao PhD, DABR (Assistant Professor) & Joseph Both PhD (Assistant Professor)

  2. Accuray Incorporated, 1310 Chesapeake Terrace, Sunnyvale, CA, 94089, USA

    Dongshan Fu PhD (Senior Imaging Scientist)

  3. CyberKnife Center of Palm Beach, 10335 N. Military Trail Suite C, Palm Beach Gardens, FL, 33410, USA

    Walter Nikesch PhD, DABR (Chief Physicist)

  4. Department of Biomedical Engineering, Florida International University, 11200 SW 8 St, Miami, FL, 33199, USA

    Zhicong Huang MD, MSc

  5. CyberKnife Centers of Miami & Palm Beach, University of Miami, 7867 N Kendall Drive, Suite 105, Miami, FL, 33156, USA

    James G. Schwade MD, FACO (Executive Director and Clinical Professor of Radiation Oncology)

  6. Leonard M. Miller School of Medicine, University of Miami, 7867 N Kendall Drive, Suite 105, Miami, FL, 33156, USA

    James G. Schwade MD, FACO (Executive Director and Clinical Professor of Radiation Oncology)

  7. Department of Radiation Oncology, University of Miami Leonard M. Miller School of Medicine, 1475 NW 12 Ave, Miami, FL, 33136, USA

    Arnold M. Markoe MD, ScD (Professor and Chairman)

Authors
  1. Xiaodong Wu PhD, DABR
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  2. Dongshan Fu PhD
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  3. Alberto de la Zerda PhD, DABR
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  4. Elizabeth Bossart PhD, DABR
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  5. Hua Shao PhD, DABR
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  6. Joseph Both PhD
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  7. Walter Nikesch PhD, DABR
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  8. Zhicong Huang MD, MSc
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  9. Arnold M. Markoe MD, ScD
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  10. James G. Schwade MD, FACO
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Editor information

Editors and Affiliations

  1. Research, Education and Clinical Excellence, Baylor University Medical Center, 1201 Barnett Tower 3600 Gaston Avenue, Dallas, TX, 75246, USA

    Harold C. Urschel Jr. MD (Chair of Cardiovascular and Thoracic Surgical) (Chair of Cardiovascular and Thoracic Surgical)

  2. Arizona Oncology Services at St. Joseph’s Hospital & Medical Center Department of Radiation Oncology CyberKnife Center Barrow Neurological Institute, Gamma Knife Center, 350 West Thomas Road, Phoenix, Arizona, 85013, USA

    John J. Kresl MD, PhD

  3. The Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh Medical Center, PUH, C-800, 200 Lothrop Street, Pittsburgh, PA, 15213, USA

    James D. Luketich MD (Sampson Family Endowed Professor of Surgery Chief) (Sampson Family Endowed Professor of Surgery Chief)

  4. Department of Radiation Oncology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, TX, 75390, USA

    Lech Papiez PhD (Associate Professor) & Robert D. Timmerman MD (Professor and Vice-Chairman Effie Marie Cain Distinguished Chair in Cancer Therapy Research) (Associate Professor) &  (Professor and Vice-Chairman Effie Marie Cain Distinguished Chair in Cancer Therapy Research)

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© 2007 Springer-Verlag Berlin Heidelberg

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Wu, X. et al. (2007). Patient Alignment and Target Tracking in Radiosurgery of Soft-Tissue Tumors Using Combined Fiducial and Skeletal Structures Tracking Techniques. In: Urschel, H.C., Kresl, J.J., Luketich, J.D., Papiez, L., Timmerman, R.D., Schulz, R.A. (eds) Treating Tumors that Move with Respiration. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69886-9_3

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  • DOI: https://doi.org/10.1007/978-3-540-69886-9_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-69885-2

  • Online ISBN: 978-3-540-69886-9

  • eBook Packages: MedicineMedicine (R0)

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