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Optical Coherence Tomography: Technique and Applications

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Advanced Imaging in Biology and Medicine

Abstract

Optical coherence tomography (OCT) is a noninvasive optical imaging modality providing real-time video rate images in two and three dimensions of biological tissues with micrometer resolution. OCT fills the gap between ultrasound and confocal microscopy, since it has a higher resolution than ultrasound and a higher penetration than confocal microcopy. Functional extensions are also possible, i.e., flow, birefringence or spectroscopic measurements with high spatial resolution. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring the treatment of a number of retinal diseases. The potential of OCT in many other applications is currently being explored, such as in developmental biology, skin cancer diagnostics, vulnerable plaque detection in cardiology, esophageal diagnostics and a number of other applications within oncology.

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Authors and Affiliations

  1. Department of Photonics Engineering, Technical University of Denmark, Frederiksborgvej 399, Roskilde, DK-4000, Denmark

    J. B. Thomsen, B. Sander, M. Mogensen, L. Thrane, T. M. Jørgensen, G. B. E. Jemec & P. E. Andersen

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  1. J. B. Thomsen
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  2. B. Sander
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  3. M. Mogensen
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  4. L. Thrane
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  5. T. M. Jørgensen
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  6. G. B. E. Jemec
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Correspondence to P. E. Andersen .

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Editors and Affiliations

  1. Sun Center of Excellence for Visual Genomics Department of Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    Christoph W. Sensen

  2. Department of Cell Biology and Anatomy, G503 Health Sciences Ctr., University of Calgary, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1, Canada

    Benedikt Hallgrímsson

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Thomsen, J.B. et al. (2009). Optical Coherence Tomography: Technique and Applications. In: Sensen, C.W., Hallgrímsson, B. (eds) Advanced Imaging in Biology and Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68993-5_5

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