Skip to main content
SpringerLink
Log in

Bone Sarcomas

  • Chapter
Cancer in Adolescents and Young Adults

Part of the book series: Pediatric Oncology ((PEDIATRICO))

  • 1320 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bleyer WA, O’Leary M, Barr R, Ries LAG (eds) (2006) Cancer Epidemiology in Older Adolescents and Young Adults 15 to 29 Years of Age, including SEER Incidence and Survival, 1975–2000. National Cancer Institute, NIH Pub. No. 06-5767, Bethesda MD; also available at www.seer.cancer.gov/publications

    Google Scholar 

  2. Ries L, Eisner M, Kosary C, et al (2004) SEER Cancer Statistics Review, 1975–2001, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2001

    Google Scholar 

  3. Dahlin DC, Coventry MB (1967) Osteogenic sarcoma. A study of six hundred cases. J Bone Joint Surg Am 49:101–110

    PubMed  CAS  Google Scholar 

  4. Cotterill SJ, Wright CM, Pearce MS, et al (2004) Stature of young people with malignant bone tumors. Pediatr Blood Cancer 42:59–63

    Article  PubMed  Google Scholar 

  5. Tucker MA, D’Angio GJ, Boice JD Jr, et al (1987) Bone sarcomas linked to radiotherapy and chemotherapy in children. N Engl J Med 317:588–593

    Article  PubMed  CAS  Google Scholar 

  6. Tabone MD, Terrier P, Pacquement H, et al (1999) Outcome of radiation-related osteosarcoma after treatment of childhood and adolescent cancer: a study of 23 cases. J Clin Oncol 17:2789–95

    PubMed  CAS  Google Scholar 

  7. Pritchard DJ, Finkel MP, Reilly CA Jr (1975) The etiology of osteosarcoma. A review of current considerations. Clin Orthop 111:14–22

    Article  PubMed  Google Scholar 

  8. Basombrio MA (1970) Search for common antigenicities among twenty-five sarcomas induced by methylcholanthrene. Cancer Res 30:2458–2462

    PubMed  CAS  Google Scholar 

  9. Price CH, Moore M, Jones DB (1972) FBJ virus-induced tumours in mice. A histopathological study of FBJ virus tumours and their relevance to murine and human osteosarcoma arising in bone. Br J Cancer 26:15–27

    PubMed  CAS  Google Scholar 

  10. Sekiguchi M, Miyazaki S, Fujikawa K, et al (1996) BK virus-induced osteosarcoma (Os515) as a model of human osteosarcoma. Anticancer Res 16:1835–1842

    PubMed  CAS  Google Scholar 

  11. Desai P, Perino G, Present D, et al (1996) Sarcoma in association with bone infarcts. Report of five cases. Arch Pathol Lab Med 120:482–489

    PubMed  CAS  Google Scholar 

  12. Resnik CS, Aisner SC, Young JW, et al (1993) Case report 767. Osteosarcoma arising in bone infarction. Skeletal Radiol 22:58–61

    PubMed  CAS  Google Scholar 

  13. Hansen MF, Cavenee WK (1987) Retinoblastoma and osteosarcoma: the prototypic cancer family. Acta Paediatr Jpn 29:526–533

    PubMed  CAS  Google Scholar 

  14. Hansen MF (1991) Molecular genetic considerations in osteosarcoma. Clin Orthop 270:237–246

    PubMed  Google Scholar 

  15. Malkin D, Jolly KW, Barbier N, et al (1992) Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J Med 326:1309–1315

    Article  PubMed  CAS  Google Scholar 

  16. Diller L, Kassel J, Nelson CE, et al (1990) p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol 10:5772–5781

    PubMed  CAS  Google Scholar 

  17. Miller CW, Aslo A, Won A, et al (1996) Alterations of the p53, Rb and MDM2 genes in osteosarcoma. J Cancer Res Clin Oncol 122:559–565

    Article  PubMed  CAS  Google Scholar 

  18. Temple HT, Scully SP, O’Keefe RJ, et al (2000) Clinical outcome of 38 patients with juxtacortical osteosarcoma. Clin Orthop 373:208–217

    Article  PubMed  Google Scholar 

  19. Papagelopoulos PJ, Galanis E, Sim FH, et al (1999) Periosteal osteosarcoma. Orthopedics 22:971–974

    PubMed  CAS  Google Scholar 

  20. Nakajima H, Sim FH, Bond JR, et al (1997) Small cell osteosarcoma of bone. Review of 72 cases. Cancer 79:2095–2106

    Article  PubMed  CAS  Google Scholar 

  21. Wolf RE, Enneking WF (1996) The staging and surgery of musculoskeletal neoplasms. Orthop Clin North Am 27:473–481

    PubMed  CAS  Google Scholar 

  22. Kager L, Zoubek A, Potschger U, et al (2003) Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol 21:2011–2018

    Article  PubMed  Google Scholar 

  23. Link MP, Goorin AM, Miser AW, et al (1986) The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 314:1600–1606

    Article  PubMed  CAS  Google Scholar 

  24. Link MP, Goorin AM, Horowitz M, et al (1991) Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study. Clin Orthop 270:8–14

    PubMed  Google Scholar 

  25. Machak GN, Tkachev SI, Solovyev YN, et al (2003) Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities. Mayo Clin Proc 78:147–155

    Article  PubMed  Google Scholar 

  26. Kamada T, Tsujii H, Tsuji H, et al (2002) Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J Clin Oncol 20:4466–4471

    Article  PubMed  CAS  Google Scholar 

  27. Goorin AM, Schwartzentruber DJ, Devidas M, et al (2003) Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. J Clin Oncol 21:1574–1580

    Article  PubMed  CAS  Google Scholar 

  28. Edmonson JH, Green SJ, Ivins JC, et al. A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2:152–6, 1984

    PubMed  CAS  Google Scholar 

  29. Meyers PA, Gorlick R, Heller G, et al (1998) Intensification of preoperative chemotherapy for osteogenic sarcoma: results of the Memorial Sloan-Kettering (T12) protocol. J Clin Oncol 16:2452–2458

    PubMed  CAS  Google Scholar 

  30. Provisor AJ, Ettinger LJ, Nachman JB, et al (1997) Treatment of nonmetastatic osteosarcoma of the extremity with preoperative and postoperative chemotherapy: a report from the Children’s Cancer Group. J Clin Oncol 15:76–84

    PubMed  CAS  Google Scholar 

  31. Szendroi M, Antal I, Koos R, et al (2000) Results of limb-saving surgery and prognostic factors in patients with osteosarcoma. Orv Hetil 141:2175–2182

    PubMed  CAS  Google Scholar 

  32. Meyers PA, Heller G, Healey JH, et al (1993) Osteogenic sarcoma with clinically detectable metastasis at initial presentation. J Clin Oncol 11:449–453

    PubMed  CAS  Google Scholar 

  33. Meyer WH, Schell MJ, Kumar AP, et al (1987) Thoracotomy for pulmonary metastatic osteosarcoma. An analysis of prognostic indicators of survival. Cancer 59:374–379

    Article  PubMed  CAS  Google Scholar 

  34. Beattie EJ Jr, Martini N, Rosen G (1975) The management of pulmonary metastases in children with osteogenic sarcoma with surgical resection combined with chemotherapy. Cancer 35:618–621

    Article  PubMed  Google Scholar 

  35. Saeter G, Hoie J, Stenwig AE, et al (1995) Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival. Cancer 75:1084–1093

    CAS  Google Scholar 

  36. Karnak I, Emin Senocak M, Kutluk T, et al (2002) Pulmonary metastases in children: an analysis of surgical spectrum. Eur J Pediatr Surg 12:151–158

    Article  PubMed  CAS  Google Scholar 

  37. Goorin AM, Harris MB, Bernstein M, et al (2002) Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: a pediatric oncology group trial. J Clin Oncol 20:426–433

    Article  PubMed  CAS  Google Scholar 

  38. Bacci G, Briccoli A, Ferrari S, et al (2000) Neoadjuvant chemotherapy for osteosarcoma of the extremities with synchronous lung metastases: treatment with cisplatin, adriamycin and high dose of methotrexate and ifosfamide. Oncol Rep 7:339–346

    PubMed  CAS  Google Scholar 

  39. Edmonson JH, Green SJ, Ivins JC, et al (1984) A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2:152–156

    PubMed  CAS  Google Scholar 

  40. Bacci G, Briccoli A, Rocca M, et al (2003) Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide. Ann Oncol 14:1126–1134

    Article  PubMed  CAS  Google Scholar 

  41. Ferrari S, Briccoli A, Mercuri M, et al (2003) Postrelapse survival in osteosarcoma of the extremities: prognostic factors for long-term survival. J Clin Oncol 21:710–715

    Article  PubMed  Google Scholar 

  42. Aung L, Gorlick RG, Shi W, et al (2002) Second malignant neoplasms in long-term survivors of osteosarcoma: Memorial Sloan-Kettering Cancer Center experience. Cancer 95:1728–1734

    Article  PubMed  Google Scholar 

  43. Hosalkar HS, Henderson KM, Weiss A, et al (2004) Chemotherapy for bone sarcoma does not affect fertility rates or childbirth. Clin Orthop Relat Res 428:256–260

    Article  PubMed  Google Scholar 

  44. Longhi A, Pignotti E, Versari M, et al (2003) Effect of oral contraceptive on ovarian function in young females undergoing neoadjuvant chemotherapy treatment for osteosarcoma. Oncol Rep 10:151–155

    PubMed  Google Scholar 

  45. Meistrich ML, Chawla SP, Da Cunha MF, et al (1989) Recovery of sperm production after chemotherapy for osteosarcoma. Cancer 63:2115–2123

    Article  PubMed  CAS  Google Scholar 

  46. Bacci G, Ferrari S, Bertoni F, et al (2000) Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the Istituto Ortopedico Rizzoli according to the Istituto Ortopedico Rizzoli/osteosarcoma-2 protocol: an updated report. J Clin Oncol 18:4016–4027

    PubMed  CAS  Google Scholar 

  47. Parkin DM, Stiller CA, Nectoux J (1993) International variations in the incidence of childhood bone tumours. Int J Cancer 53:371–376

    Article  PubMed  CAS  Google Scholar 

  48. Li FP, Tu JT, Liu FS, et al (1980) Rarity of Ewing’s sarcoma in China. Lancet 1:1255

    Article  PubMed  CAS  Google Scholar 

  49. Fraumeni JF Jr, Glass AG (1970) Rarity of Ewing’s sarcoma among U.S. Negro children. Lancet 1:366–367

    Article  PubMed  Google Scholar 

  50. Joyce MJ, Harmon DC, Mankin HJ, et al (1984) Ewing’s sarcoma in female siblings. A clinical report and review of the literature. Cancer 53:1959–1962

    Article  PubMed  CAS  Google Scholar 

  51. Zamora P, Garcia de Paredes ML, Gonzalez Baron M, et al (1986) Ewing’s tumor in brothers. An unusual observation. Am J Clin Oncol 9:358–360

    Article  PubMed  CAS  Google Scholar 

  52. Hutter RV, Francis KC, Foote FW Jr (1964) Ewing’s sarcoma in siblings: report of the second known occurrence. Am J Surg 107:598–603

    Article  PubMed  CAS  Google Scholar 

  53. Aparicio J, Segura A, Montalar J, et al (1998) Secondary cancers after Ewing sarcoma and Ewing sarcoma as second malignant neoplasm. Med Pediatr Oncol 30:259–260

    Article  PubMed  CAS  Google Scholar 

  54. Delattre O, Zucman J, Melot T, et al (1994) The Ewing family of tumors — a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 331:294–299

    Article  PubMed  CAS  Google Scholar 

  55. Delattre O, Zucman J, Plougastel B, et al (1992) Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 359:162–165

    Article  PubMed  CAS  Google Scholar 

  56. Lessnick SL, Braun BS, Denny CT, et al (1995) Multiple domains mediate transformation by the Ewing’s sarcoma EWS/FLI-1 fusion gene. Oncogene 10:423–431

    PubMed  CAS  Google Scholar 

  57. Sorensen PH, Lessnick SL, Lopez-Terrada D, et al (1994) A second Ewing’s sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet 6:146–151

    Article  PubMed  CAS  Google Scholar 

  58. Arvand A, Denny CT (2001) Biology of EWS/ETS fusions in Ewing’s family tumors. Oncogene 20:5747–5754

    Article  PubMed  CAS  Google Scholar 

  59. Perlman EJ, Dickman PS, Askin FB, et al (1994) Ewing’s sarcoma — routine diagnostic utilization of MIC2 analysis: a Pediatric Oncology Group/Children’s Cancer Group Intergroup Study. Hum Pathol 25:304–307

    Article  PubMed  CAS  Google Scholar 

  60. de Alava E, Gerald WL (2000) Molecular biology of the Ewing’s sarcoma/primitive neuroectodermal tumor family. J Clin Oncol 18:204–213

    PubMed  Google Scholar 

  61. Smithey BE, Pappo AS, Hill DA (2002) C-kit expression in pediatric solid tumors: a comparative immunohistochemical study. Am J Surg Pathol 26:486–492

    Article  PubMed  Google Scholar 

  62. Scotlandi K, Manara MC, Strammiello R, et al (2003) C-kit receptor expression in Ewing’s sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions. J Clin Oncol 21:1952–1960

    Article  PubMed  CAS  Google Scholar 

  63. Jurgens HF (1994) Ewing’s sarcoma and peripheral primitive neuroectodermal tumor. Curr Opin Oncol 6:391–396

    Article  PubMed  CAS  Google Scholar 

  64. Pritchard DJ, Dahlin DC, Dauphine RT, et al (1975) Ewing’s sarcoma. A clinicopathological and statistical analysis of patients surviving five years or longer. J Bone Joint Surg Am 57:10–16

    PubMed  CAS  Google Scholar 

  65. Kissane JM, Askin FB, Foulkes M, et al (1983) Ewing’s sarcoma of bone: clinicopathologic aspects of 303 cases from the Intergroup Ewing’s Sarcoma Study. Hum Pathol 14:773–779

    PubMed  CAS  Google Scholar 

  66. Grier HE, Krailo MD, Tarbell NJ, et al (2003) Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 348:694–701

    Article  PubMed  CAS  Google Scholar 

  67. van der Woude HJ, Bloem JL, Hogendoorn PC (1998) Preoperative evaluation and monitoring chemotherapy in patients with high-grade osteogenic and Ewing’s sarcoma: review of current imaging modalities. Skeletal Radiol 27:57–71

    Article  PubMed  Google Scholar 

  68. Bernstein M, Devidas M, Lafreniere D, et al (2006) Intensive Therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis, POG/CCG phase II study 9457: a report from the Children’s Oncology Group. J Clin Oncol 24:152–159

    Article  PubMed  CAS  Google Scholar 

  69. Miser JS, Krailo MD, Tarbell NJ, et al (2004) Treatment of metastatic Ewing’s sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide — a Children’s Cancer Group and Pediatric Oncology Group study. J Clin Oncol 22:2873–2876

    Article  PubMed  CAS  Google Scholar 

  70. Schleiermacher G, Peter M, Oberlin O, et al (2003) Increased risk of systemic relapses associated with bone marrow micrometastasis and circulating tumor cells in localized Ewing tumor. J Clin Oncol 21:85–91

    Article  PubMed  Google Scholar 

  71. Kenney LB, Laufer MR, Grant FD, et al (2001) High risk of infertility and long term gonadal damage in males treated with high dose cyclophosphamide for sarcoma during childhood. Cancer 91:613–621

    Article  PubMed  CAS  Google Scholar 

  72. Nesbit ME Jr, Gehan EA, Burgert EO Jr, et al (1990) Multimodal therapy for the management of primary, nonmetastatic Ewing’s sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol 8:1664–1674

    PubMed  Google Scholar 

  73. Oberlin O, Habrand JL, Zucker JM, et al (1992) No benefit of ifosfamide in Ewing’s sarcoma: a nonrandomized study of the French Society of Pediatric Oncology. J Clin Oncol 10:1407–1412

    PubMed  CAS  Google Scholar 

  74. Paulussen M, Ahrens S, Dunst J, et al (2001) Localized Ewing tumor of bone: final results of the cooperative Ewing’s Sarcoma Study CESS 86. J Clin Oncol 19:1818–1829

    PubMed  CAS  Google Scholar 

  75. Rosito P, Mancini AF, Rondelli R, et al (1999) Italian Cooperative Study for the treatment of children and young adults with localized Ewing sarcoma of bone: a preliminary report of 6 years of experience. Cancer 86:421–428

    Article  PubMed  CAS  Google Scholar 

  76. Craft A, Cotterill S, Malcolm A, et al (1998) Ifosfamide-containing chemotherapy in Ewing’s sarcoma: the Second United Kingdom Children’s Cancer Study Group and the Medical Research Council Ewing’s Tumor Study. J Clin Oncol 16:3628–3633

    PubMed  CAS  Google Scholar 

  77. Granowetter L, Womer R, Devidas M, et al (2001) Comparison of dose intensified and standard dose chemotherapy for the treatment of non-metastatic Ewing sarcoma (ES) and primitive neuroectodermal tumor (PNET) of bone and soft tissue: a Pediatric Oncology Group — Children’s Cancer Group phase III trial. Med Pediatr Oncol 37:aO38:172

    Google Scholar 

  78. Cotterill SJ, Ahrens S, Paulussen M, et al (2000) Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol 18:3108–3114

    PubMed  CAS  Google Scholar 

  79. Merchant MS, Woo CW, Mackall CL, et al (2002) Potential use of imatinib in Ewing’s sarcoma: evidence for in vitro and in vivo activity. J Natl Cancer Inst 94:1673–1679

    PubMed  CAS  Google Scholar 

  80. Paulussen M, Ahrens S, Juergens HF (2003) Cure rates in Ewing tumor patients aged over 15 years are better in pediatric oncology units. Results of GPOH CESS/EICESS studies. Proc Am Soc Clin Oncol 22:816 (abstract 3279)

    Google Scholar 

  81. Saylors RL III, Stine KC, Sullivan J, et al (2001) Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: a Pediatric Oncology Group phase II study. J Clin Oncol 19:3463–3469

    PubMed  CAS  Google Scholar 

  82. Blaney SM, Needle MN, Gillespie A, et al (1998) Phase II trial of topotecan administered as 72-hour continuous infusion in children with refractory solid tumors: a collaborative Pediatric Branch, National Cancer Institute, and Children’s Cancer Group Study. Clin Cancer Res 4:357–360

    PubMed  CAS  Google Scholar 

  83. McLean TW, Hertel C, Young ML, et al (1999) Late events in pediatric patients with Ewing sarcoma/primitive neuroectodermal tumor of bone: the Dana-Farber Cancer Institute/Children’s Hospital experience. J Pediatr Hematol Oncol 21:486–493

    Article  PubMed  CAS  Google Scholar 

  84. Rodriguez-Galindo C, Billups CA, Kun LE, et al (2002) Survival after recurrence of Ewing tumors: the St Jude Children’s Research Hospital experience, 1979–1999. Cancer 94:561–569

    Article  PubMed  Google Scholar 

  85. Hayes FA, Thompson EI, Kumar M, et al (1987) Longterm survival in patients with Ewing’s sarcoma relapsing after completing therapy. Med Pediatr Oncol 15:254–256

    Article  PubMed  CAS  Google Scholar 

  86. Kuttesch JF Jr, Wexler LH, Marcus RB, et al (1996) Second malignancies after Ewing’s sarcoma: radiation dose-dependency of secondary sarcomas. J Clin Oncol 14:2818–2825

    PubMed  Google Scholar 

  87. Dunst J, Ahrens S, Paulussen M, et al (1998) Second malignancies after treatment for Ewing’s sarcoma: a report of the CESS-studies. Int J Radiat Oncol Biol Phys 42:379–384

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dana Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115, USA

    Michael S. Isakoff M.D., Mark C. Gebhardt M.D. & Holcombe E. Grier M.D.

  2. Hackensack University Medical Center, 30 Porspect Are, Hackensack, NJ, 07601, USA

    Michael J. Harris M.D.

Authors
  1. Michael S. Isakoff M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael J. Harris M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mark C. Gebhardt M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Holcombe E. Grier M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St. Charles Medical Center, Bend, Oregon, USA

    W. Archie Bleyer

  2. McMaster University, Hamilton, Ontario, Canada

    Ronald D. Barr

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Isakoff, M.S., Harris, M.J., Gebhardt, M.C., Grier, H.E. (2007). Bone Sarcomas. In: Bleyer, W.A., Barr, R.D. (eds) Cancer in Adolescents and Young Adults. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68152-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-68152-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40842-0

  • Online ISBN: 978-3-540-68152-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation