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Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials pp 239–256Cite as

Contrast-Enhanced Micro-CT Imaging of Soft Tissues

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Abstract

Analyzing the three-dimensional (3D) structure of specimens has become increasingly important in biomedical research fields, and microcomputed tomography (micro-CT) has emerged as an effective method for rapidly and non-destructively quantifying the geometry and morphology of tissues. Though micro-CT was originally designed to assess cortical and trabecular bone microarchitecture, applications for micro-CT now extend to the imaging of soft tissues. In particular, vascular anatomy and articular cartilage degradation are of major interest to investigators in the orthopedic research areas. This chapter outlines processes and results involved in utilizing X-ray contrast agents to enhance micro-CT analyses of vasculature and articular cartilage.

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Authors and Affiliations

  1. Georgia Institute of Technology, 315 Ferst Drive, Atlanta, Georgia, 30332, USA

    Angela S.P. Lin, Ashley W. Palmer, Craig L. Duvall, Galen C. Robertson, Megan E. Oest, Bina Rai, Marc E. Levenston & Robert E. Guldberg

Authors
  1. Angela S.P. Lin
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  2. Ashley W. Palmer
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  3. Craig L. Duvall
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  4. Galen C. Robertson
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  5. Megan E. Oest
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  6. Bina Rai
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  7. Marc E. Levenston
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  8. Robert E. Guldberg
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Corresponding author

Correspondence to Angela S.P. Lin .

Editor information

Editors and Affiliations

  1. Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China

    Ling Qin (Professor) & Kwok Sui Leung (Professor of Department of Orthopaedics & Traumatology) (Professor) &  (Professor of Department of Orthopaedics & Traumatology)

  2. University of California, San Francisco

    Harry K. Genant (Professor Emeritus, Chairman Emeritus and Board of Directors) (Professor Emeritus, Chairman Emeritus and Board of Directors)

  3. Synarc, Inc, USA

    Harry K. Genant (Professor Emeritus, Chairman Emeritus and Board of Directors) (Professor Emeritus, Chairman Emeritus and Board of Directors)

  4. Department of Radiology and Organ Imaging, The Chinese University of Hong Kong, Hong Kong SAR, China

    James F. Griffith

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© 2007 Springer-Verlag Berlin Heidelberg

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Lin, A.S. et al. (2007). Contrast-Enhanced Micro-CT Imaging of Soft Tissues. In: Qin, L., Genant, H.K., Griffith, J.F., Leung, K.S. (eds) Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-45456-4_15

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  • DOI: https://doi.org/10.1007/978-3-540-45456-4_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-45454-0

  • Online ISBN: 978-3-540-45456-4

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