Abstract
During eyeblink conditioning, Purkinje cells that control blinking develop an inhibitory response to the conditional stimulus. This conditional response (CR) in the Purkinje cell shows a number of striking similarities to the overt blink CR, including adaptive timing. The evidence suggests that the Purkinje cell CR drives the overt CR. Recent results show that the Purkinje cell CR does not depend on long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and time of the CR accordingly.
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Acknowledgments
This work was supported by grants from the Swedish Research Council to G.H. (2018-03191), to F.J. (2016-00127) and to the Linnaeus project “Thinking in Time: Cognition, Communication and Learning” (349-2007-8695), and grants from the Thorsten Söderberg foundation.
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Hesslow, G., Jirenhed, DA., Johansson, F. (2020). Purkinje Neurons During Eye Blink Conditioning and New Mechanisms of Cerebellar Learning and Timing. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_115-1
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