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Encyclopedia of Signaling Molecules pp 2634–2645Cite as

Integrin Alpha V (ITGAV)

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Synonyms

Alpha v integrin; CD51; Vitronectin receptor alpha (VNRA); Vitronectin receptor, alpha polypeptide

Historical Background

The term “integrin” was coined by R.O. Hynes in 1986 to describe a family of adhesion proteins which integrate the cytoskeleton with the extracellular matrix and external stimuli. These integrins are composed of alpha and beta subunits to form a complete signaling molecule. The αv subunit forms a complete integrin complex through heterodimerization with one of five β subunit binding partners: beta 1 (β1), beta 3 (β3), beta 5 (β5), beta 6 (β6), or beta 8 (β8). The first αv integrin characterized was αvβ3, which was originally termed the “vitronectin receptor,” as it bound to plasma-derived vitronectin. The αvβ3 integrin was purified from plasma in 1985 by R. Pytela and then cloned and sequenced in 1986 by S. Suzuki. The name “vitronectin receptor” was quickly proven to be a misnomer as αvβ3 displays highly promiscuous binding (Table 1). The other αv...

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Author information

Authors and Affiliations

  1. Department of Molecular Cardiology, Joseph J. Jacobs Center for Thrombosis and Vascular Biology, Lerner Research Institute, The Cleveland Clinic, 9500 Euclid Avenue, NB50, Cleveland, OH, 44195, USA

    Bethany A. Kerr & Tatiana V. Byzova

Authors
  1. Bethany A. Kerr
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  2. Tatiana V. Byzova
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Corresponding author

Correspondence to Bethany A. Kerr .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Kerr, B.A., Byzova, T.V. (2018). Integrin Alpha V (ITGAV). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_619

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