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Encyclopedia of Signaling Molecules pp 3884–3890Cite as

Peroxisome Proliferator-Activated Receptor (PPAR)

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Synonyms

NR1C1; NR1C2; NR1C3; PPARα; PPARβ/δ; PPARγ

Historical Background

PPARs were initially discovered while delineating mechanisms that induce peroxisome proliferation in rodents, hence the name of peroxisome proliferator-activated receptor. PPARα was the first identified isoform cloned from a mouse liver complementary DNA library in 1990 from researchers working on the mechanisms implicated in the promoting action of a variety of chemicals on peroxisomal proliferation in the rodent liver (Issemann and Green 1990). The identified protein presented a high degree of similarity with several members of the nuclear hormone receptor superfamily and was highly expressed in liver, kidney, heart, and brown adipose tissue. Τhe other two PPAR isoforms called PPARβ/δ and PPARγ were later identified in Xenopus laevis (Dreyer et al. 1992), human (Greene et al. 1995), and mouse (Chen et al. 1993).

PPAR Structure

PPARs’ basic structure includes several domains which interact with each other for...

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Authors and Affiliations

  1. School of Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece

    Antigone Lazou & Eleftheria Barlaka

Authors
  1. Antigone Lazou
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  2. Eleftheria Barlaka
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Correspondence to Antigone Lazou .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Lazou, A., Barlaka, E. (2018). Peroxisome Proliferator-Activated Receptor (PPAR). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101829

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