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Polish Conference on Biocybernetics and Biomedical Engineering

PCBBE 2017: Recent Developments and Achievements in Biocybernetics and Biomedical Engineering pp 218–229Cite as

Simulation Analysis of the Homologous Recombination Repair Distribution over the Cell Cycle

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Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 647))

Abstract

Double-strand breaks (DSBs) are repaired with the use of several distinct mechanisms. The most important of them are non-homologous end joining (NHEJ) and homologous recombination (HR). These mechanisms have different requirements and are characterized by different repair kinetics. Moreover, HR is restricted to S and G2 phases of the cell cycle, however it is still not clear how percentage of DSBs repaired by HR changes over the cell cycle. In this study we are trying to find the most suitable function describing participation of HR among other types of repair. Using our mathematical model, we simulate the response of average cell treated with ionizing radiation (IR) during G1 phase of the cell cycle. Our results show that the exact shape of the function describing percentage of HR is not as important as the fact that this function should be gradually increasing until at least half of the S phase.

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Acknowledgments

This project was funded by the Polish National Center for Science granted by decision number DEC-2013/11/B/ST7/01713 (K.P.) and the Polish BKM fund supporting young researchers (M.K.).

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Authors and Affiliations

  1. Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, Akademicka 16, 44-100, Gliwice, Poland

    Monika Kurpas & Krzysztof Puszynski

Authors
  1. Monika Kurpas
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  2. Krzysztof Puszynski
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Corresponding author

Correspondence to Monika Kurpas .

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Editors and Affiliations

  1. AGH University of Science and Technology, Krakow, Poland

    Piotr Augustyniak

  2. Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland

    Roman Maniewski

  3. AGH University of Science and Technology, Krakow, Poland

    Ryszard Tadeusiewicz

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Kurpas, M., Puszynski, K. (2018). Simulation Analysis of the Homologous Recombination Repair Distribution over the Cell Cycle. In: Augustyniak, P., Maniewski, R., Tadeusiewicz, R. (eds) Recent Developments and Achievements in Biocybernetics and Biomedical Engineering. PCBBE 2017. Advances in Intelligent Systems and Computing, vol 647. Springer, Cham. https://doi.org/10.1007/978-3-319-66905-2_19

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  • DOI: https://doi.org/10.1007/978-3-319-66905-2_19

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-66904-5

  • Online ISBN: 978-3-319-66905-2

  • eBook Packages: EngineeringEngineering (R0)

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