Skip to main content
SpringerLink
Log in

Compliance and Psychoeducation

  • Living reference work entry
  • First Online:
NeuroPsychopharmacotherapy

  • 252 Accesses

Abstract

Noncompliance or nonadherence is a well-known but still underestimated problem in pharmacological treatment in general and in neuropsychopharmacological therapy in detail. Approximately 50% of all patients with chronic diseases exhibit poor compliance regarding drug therapy. Poor adherence is a worldwide problem of striking magnitude. Increasing the effectiveness of adherence interventions might have a far greater impact than any improvement in specific medical treatments. Psychoeducation is effective and has the potential to reduce the rate of nonadherence significantly.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Aagaard J, Foldager L, Makki A, Hansen V, Müller-Nielsen K. The efficacy of psychoeducation on recurrent depression: a randomized trial with a 2-year follow-up. Nord J Psychiatry. 2017; 71:223–9.

    Article  PubMed  Google Scholar 

  • Anderson IM, Tomenson BM. Treatment discontinuation with selective serotonin reuptake inhibitors compared with tricyclic antidepressants: a meta-analysis. Br Med J. 1995;310:1433–8.

    Article  CAS  Google Scholar 

  • Anderson JP, Icten Z, Alas V, Benson C, Joshi K. Comparison and predictors of treatment adherence and remission among patients with schizophrenia treated with paliperidone palmitate or atypical oral antipsychotics in community behavioral health organizations. BMC Psychiatry. 2017; 17:346.

    Article  PubMed  PubMed Central  Google Scholar 

  • Arlt AD, Nestoriuc Y, Rief W. Why current drug adherence programs fail: addressing psychological risk factors of nonadherence. Curr Opin Psychiatry. 2017;30:326–33.

    Article  PubMed  Google Scholar 

  • Bäuml J, Behrendt B, Henningsen P, Pitschel-Walz G. Handbuch der Psychoedukation. Stuttgart: Schattauer; 2016.

    Google Scholar 

  • Berk L, Hallam KT, Colom F, Vieta E, Hasty M, Macneil C, Berk M. Enhancing medication adherence in patients with bipolar disorder. Human Psychopharmacology: Clinical and Experimental 2010;25(1):1–16.

    Article  Google Scholar 

  • Bohlken J, Weber S, Rapp MA, Kostev K. Continuous treatment with antidementia drugs in Germany 2003–2013: a retrospective database analysis. Int Psychogeriatr. 2015;27:1335–42.

    Article  PubMed  Google Scholar 

  • Buck D, Jacoby A, Baker GA, Chadwick DW. Factors influencing compliance with antiepileptic drug regimes. Seizure. 1997;6:87–93.

    Article  CAS  PubMed  Google Scholar 

  • Chen R, Zhu X, Capitao LP, Zhang H, Luo J, Wang X, Xi Y, Song X, Feng Y, Cao L, Malhi GS. Psychoeducation for psychiatric inpatients following remission of a manic episode in bipolar I disorder: a randomized controlled trial. Bipolar Disord. 2019;21:76–85.

    Article  PubMed  Google Scholar 

  • Claxton A, Klerk E. de, Parry M, Robinson JM, Schmidt ME. Patient compliance to a new enteric-coated weekly formulation of fluoxetine during continuation treatment of major depressive disorder. The Journal of Clinical Psychiatry 2000;61(12):928–932.

    Article  CAS  PubMed  Google Scholar 

  • Cloyd JC, Kriel RL, Jones-Saete CM, Ong BY, Jancik JT, Remmel RP. Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance, and preference. J Pediatr. 1992;120:634–8.

    Article  CAS  PubMed  Google Scholar 

  • Conradi HJ, Bos EH, Kamphuis JH, de Jonge P. The ten-years course of depression in primary care and long-term effects of psychoeducation, psychiatric consultation and cognitive behavioral therapy. J Affect Disord. 2017;217:174–82.

    Article  PubMed  Google Scholar 

  • De Las Cuevas C, de Leon J. Reviving research on medication attitudes for improving pharmacotherapy: focusing on adherence. Psychother Psychosom. 2017;86:73–9.

    Article  PubMed  Google Scholar 

  • De Las Cuevas C, Penate W, Cabrera C. Perceived health control: a promising step forward in our understanding of treatment adherence in psychiatric care. J Clin Psychiatry. 2016;77:e1233–9.

    Article  PubMed  Google Scholar 

  • De Leon J, de Las Cuevas C. The art of pharmacotherapy – reflections on pharmacophobia. J Clin Psychopharmacol. 2017;37:131–7.

    Article  PubMed  Google Scholar 

  • Demyttenaere K. Noncompliance with antidepressants: who’s to blame? Int Clin Psychopharmacol. 1998;13:S19–25.

    Article  PubMed  Google Scholar 

  • Ekselius L, Bengtsson F, von Knorring L. Non-compliance with pharmacotherapy of depression is associated with a sensation seeking personality. Int Clin Psychopharmacol. 2000;15:273–8.

    Article  CAS  PubMed  Google Scholar 

  • Furukawa TA, Streiner DL, Young LT. Is antidepressant-benzodiazepine combination therapy clinically more useful? A meta-analytic study. J Affect Disord. 2001;5:173–7.

    Article  Google Scholar 

  • Garnett WR. Antiepileptic drug treatment: outcomes and adherence. Pharmacotherapy. 2000;20:S191–9.

    Article  Google Scholar 

  • Getnet A, Woldeyohannes SM, Bekana L, Mekonen T, Fekadu W, Menberu M, Yimer S, Assaye A, Belete A, Belete H. Antiepileptic drug nonadherence and its predictors among people with epilepsy. Behav Neurol. 2016;2016:3189108.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gold DT, McClung B. Approaches to patient education: emphasizing the long-term value of compliance and persistence. Am J Med. 2006;119:S32–7.

    Article  PubMed  Google Scholar 

  • Greene M, Paladini L, Lemmer T, Piedade A, Touya M, Clark O. Systematic literature review on patterns of pharmacological treatment and adherence among patients with bipolar disorder type I in the USA. Neuropsychiatr Dis Treat. 2018;14:1545–59.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gutierrez PM, Wortzel HS, Forster JE, Leitner RA, Hostetter TA, Brenner LA. Blister packaging medication increases treatment adherence in psychiatric patients. J Psychiatr Pract. 2017;23: 320–7.

    Article  PubMed  Google Scholar 

  • Haddad PM, Brain C, Scott J. Nonadherence with antipsychotic medication in schizophrenia: challenges and management strategies. Patient Relat Outcome Meas. 2014;5:43–62.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hargrave R, Remler MP. Noncompliance. J Natl Med Assoc. 1996;88:7, 11

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hatch A, Docherty JP, Carpenter D, Ross R, Weiden PJ. Expert consensus survey on medication adherence in psychiatric patients and use of a digital medicine system. J Clin Psychiatry. 2017; 78:e803–12.

    Article  PubMed  Google Scholar 

  • Hiemke C, Bergemann N, Clement HW, Conca A, Deckert J, Domschke K, Eckermann G, Egberts K, Gerlach M, Greiner C, Gründer G, Haen E, Havemann-Reinecke U, Hefner G, Helmer R, Janssen G, Jaquenoud E, Laux G, Messer T, Mössner R, Müller MJ, Paulzen M, Pfuhlmann B, Riederer P, Saria A, Schoppek B, Schoretsanitis G, Schwarz M, Gracia MS, Stegmann B, Steimer W, Stingl JC, Uhr M, Ulrich S, Unterecker S, Waschgler R, Zernig G, Zurek G, Baumann P. Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017. Pharmacopsychiatry. 2018;51:9–62.

    Article  CAS  PubMed  Google Scholar 

  • Ho SC, Jacob SA, Tangiisuran B. Barriers and facilitators of adherence to antidepressants among outpatients with major depressive disorder: a qualitative study. PLoS One. 2017;12:e0179290.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Hotopf M, Hardy R, Lewis G. Discontinuation rates of SSRIs and tricyclic antidepressants: a meta-analysis and investigation of heterogeneity. Br J Psychiatry. 1997;170:120–7.

    Article  CAS  PubMed  Google Scholar 

  • Jawad I, Watson S, Haddad PM, Talbot PS, McAllister-Williams RH. Medication nonadherence in bipolar disorder: a narrative review. Ther Adv Psychopharmacol. 2018;8:349–63.

    Article  PubMed  PubMed Central  Google Scholar 

  • Joe S, Lee JS. Association between non-compliance with psychiatric treatment and non-psychiatric service utilization and costs in patients with schizophrenia and related disorders. BMC Psychiatry. 2016;16:444.

    Article  PubMed  PubMed Central  Google Scholar 

  • Katon W. Collaborative management to achieve treatment guidelines. JAMA 1995;273(13):1026.

    Article  CAS  PubMed  Google Scholar 

  • Katon W, von Korff M, Lin E, Bush T, Ormel J. Adequacy and duration of antidepressant treatment in primary care. Med Care. 1992;30:67–76.

    Article  CAS  PubMed  Google Scholar 

  • Katon W, Von Korff M, Lin E, Simon G, Walker E, Unützer J, Bush T, Russo J, Ludman E. Stepped collaborative care for primary care patients with persistent symptoms of depression: a randomized trial. Arch Gen Psychiatry. 1999;56:1109–15.

    Article  CAS  PubMed  Google Scholar 

  • Keeley R, Smith M, Miller J. Somatiform symptoms and treatment nonadherence in depressed family medicine outpatients. Arch Fam Med. 2000;9:46–54.

    Article  CAS  PubMed  Google Scholar 

  • Krijnen-de Bruin E, Muntingh AD, Hoogendoorn AW, van Straten A, Batelaan NM, Maarsingh OR, van Balkom AJ, van Meijel B. The GET READY relapse prevention programme for anxiety and depression: a mixed-methods study protocol. BMC Psychiatry. 2019;19:64.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lannon SL. Using a health promotion model to enhance medication compliance. J Neurosci Nurs. 1997;29:170–8.

    Article  CAS  PubMed  Google Scholar 

  • Lin EH, Von Korff M, Katon W, Bush T, Simon GE, Walker E, Robinson P. The role of the primary care physician in patients’ adherence to antidepressant therapy. Med Care. 1995;33:67–74.

    Article  CAS  PubMed  Google Scholar 

  • Lin EH, Simon GE, Katon WJ, Russo JE, Von Korff M, Bush TM, Ludman EJ, Walker EA. Can enhanced acute-phase treatment of depression improve long-term outcomes? A report of randomized trial in primary care. Am J Psychiatry. 1999;156:643–5.

    CAS  PubMed  Google Scholar 

  • Lorig KR, Sobel DS, Stewart AL, Brown BW, Bandura A, Ritter P, Gonzalez VM, Laurent DD, Holman HR. Evidence suggesting that a chronic disease self-management program can improve health status while reducing hospitalization: a randomized trial. Med Care. 1999;37:5–14.

    Article  CAS  PubMed  Google Scholar 

  • Mathes T, Pieper D, Antoine SL, Eikermann M. 50% adherence of patients suffering chronic conditions – where ist he evidence? Ger Med Sci. 2012;10:Doc16.

    PubMed  PubMed Central  Google Scholar 

  • Melin EO, Svensson R, Thulesius HO. Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. Scand J Prim Health Care. 2018;36:123–33.

    Article  PubMed  PubMed Central  Google Scholar 

  • Michaelis R, Tang V, Goldstein LH, Reuber M, LaFrance WC, Lundgren T, Modi AC, Wagner JL. Psychological treatments for adults and children with epilepsy: evidence-based recommendations by the international league against epilepsy psychology task force. Epilepsia. 2018;59:1282–302.

    Article  PubMed  Google Scholar 

  • Montgomery SA, Kasper S. Comparison of compliance between serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis. Int Clin Psychopharmacol. 1995;9:33–40.

    Article  PubMed  Google Scholar 

  • Myers ED, Branthwaite A. Out-patient compliance with antidepressant medication. Br J Psychiatry. 1992;160:83–6.

    Article  CAS  PubMed  Google Scholar 

  • National Institute for Health and Care Excellence. Medicines adherence: involving patients in decisions about prescribed medicines and supporting adherence. NICE guidelines CG76. London: Royal College of General Practitioners; 2009.

    Google Scholar 

  • Pennington M, McCrone P. Does non-adherence increase treatment costs in schizophrenia? Pharmacoeconomics. 2018;36:941–55.

    Article  PubMed  Google Scholar 

  • Peveler R, George C, Kinmonth AL, Campbell M, Thompson C. Effect of antidepressant drug counselling and information leaflets on adherence to drug treatment in primary care: randomised controlled trial. BMJ. 1999;319:612–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Phan SV. Medication adherence in patients with schizophrenia. Int J Psychiatry Med. 2016;51:211–9.

    Article  PubMed  Google Scholar 

  • Pilon D, Tandon N, Lafeuille MH, Kamstra R, Emond B, Lefebvre P, Joshi K. Treatment pattern, health care resource utilization, and spending in Medicaid beneficiaries initiating second-generation long-acting injectable agents versus oral atypical antipsychotics. Clin Ther. 2017; 39:1972–85.

    Article  CAS  PubMed  Google Scholar 

  • Pompili M, Giordano G, Luciano M, Lamis DA, Del Vecchio V, Serafini G, Sampogna G, Erbuto D, Falkai P, Fiorillo A. Unmet needs in schizophrenia. CNS Neurol Disord Drug Targets. 2017;16:870–84.

    Article  CAS  PubMed  Google Scholar 

  • Profit D, Rohatagi S, Zhao C, Hatch A, Docherty JP, Peters-Strickland TS. Developing a digital medicine system in psychiatry: ingestion detection rate and latency period. J Clin Psychiatry. 2016;77:e1095–100.

    Article  PubMed  Google Scholar 

  • Rohatagi S, Profit D, Hatch A, Zhao C, Docherty JP, Peters-Strickland TS. Optimization of a digital medicine system in psychiatry. J Clin Psychiatry. 2016;77:e1101–7.

    Article  PubMed  Google Scholar 

  • Sendt KV, Tracy DK, Bhattacharyya S. A systematic review of factors influencing adherence to antipsychotic medication in schizophrenia-spectrum disorders. Psychiatry Res. 2015;225: 14–30.

    Article  PubMed  Google Scholar 

  • Serna MC, Real J, Cruz I, Galvan L, Martin E. Monitoring patients on chronic treatment with antidepressants between 2003 and 2011: analysis of factors associated with compliance. BMC Public Health. 2015;15:1184.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sirey JA, Banerjee S, Marino P, Bruce ML, Halkett A, Turnwald M, Chiang C, Liles B, Artis A, Blow F, Klaes HC. Adherence to depression treatment in primary care – a randomized clinical trial. JAMA Psychiatry. 2017;74:1129–35.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wenze SJ, Armey MF, Weinstock LM, Gaudiano BA, Miller IW. An open trial of a smartphone-assisted, adjunctive intervention to improve treatment adherence in bipolar disorder. J Psychiatr Pract. 2016;22:492–504.

    Article  PubMed  PubMed Central  Google Scholar 

  • World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003. http://www.who.int/chp/knowledge/publications/adherence_report/en/

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany

    Stefan Unterecker

Authors
  1. Stefan Unterecker
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stefan Unterecker .

Editor information

Editors and Affiliations

  1. Dept Psychiatry , Psychosomatics & Psychotherapy, University of Würzburg, Medical School Clinical Neurochemistry, Würzburg, Germany

    Peter Riederer

  2. Inst für Psychologische Medizin, Haag, Bayern, Germany

    Gerd Laux

  3. Department of Psychiatry, University of Toronto Department of Psychiatry, Toronto, ON, Canada

    Benoit Mulsant

  4. Center Translational Res Neurol Diseases, Dalian Med Uni Shanghai Inst Health Sc Center Translational Res Neurol Diseases, Dalian, China

    Weidong Le

  5. Fujita Health University School Medicine, Toyoake, Aichi, Japan

    Toshiharu Nagatsu

Section Editor information

  1. Center of Mental Health, Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Würzburg, Germany

    Peter Riederer

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Unterecker, S. (2020). Compliance and Psychoeducation. In: Riederer, P., Laux, G., Mulsant, B., Le, W., Nagatsu, T. (eds) NeuroPsychopharmacotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-56015-1_6-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-56015-1_6-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-56015-1

  • Online ISBN: 978-3-319-56015-1

  • eBook Packages: Springer Reference MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation