Abstract
Magnetic resonance (MR) angiography is a standard method of noninvasive imaging utilized in peripheral arterial disease. As compared to percutaneous angiography, the gold standard for peripheral imaging, MR angiography offers good diagnostic accuracy with high sensitivity and specificity in identifying hemodynamically significant stenoses. Both contrast-enhanced and noncontrast-enhanced modalities of MR angiography are available. While the use of gadolinium-based contrast agents has been associated with nephrogenic systemic fibrosis, new contrast agents are being developed to avoid this complication. MR angiography compares well with other noninvasive imaging modalities, such as computed tomographic angiography, and affords better resolution and localization than duplex ultrasonography. Overall, sufficient information is provided by MR angiography for clinicians to base treatment decisions on the images acquired, and in some cases, MR angiography may even provide better imaging of target vessels than other modalities. Ongoing studies are being performed to enhance acquisition and post-processing of images, likely improving the data provided by MR angiography.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Litt H, Carpenter J. Magnetic resonance imaging. In: Cronenwett J, Johnston KW, editors. Rutherford’s vascular surgery. Philadelphia: Elselvier; 2014. p. 351–76.
Owen R, Carpenter J, Baum R, Perloff L, Cope C. Magnetic resonance imaging of angiographically occult runoff vessels in peripheral arterial occlusive disease. N Engl J Med. 1992;326:1577–81.
Koelemay M, Lijmer J, Stoker J, Legemate D, Bossuyt P. Magnetic resonance angiography for the evaluation of lower extremity arterial disease: a meta-analysis. JAMA. 2001;285:1338–45.
Meaney J. Magnetic resonance angiography of the peripheral arteries: current status. Eur Radiol. 2003;13:836–52.
Vahl A, Geselschap J, Montauban van Swijndregt A, Smit J, Sala J, Turkcan K, et al. Contrast enhanced magnetic resonance angiography versus intra-arterial digital subtraction angiography for treatment planning in patients with peripheral arterial disease: a randomized controlled diagnostic trial. Eur J Vasc Endovasc Surg. 2008;35:514–21.
Norgren L, Hiatt W, Dormandy J, Nehler M, Harris K, Fowkes F, et al. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg. 2007;45:S6A–S67A.
Zhu Y, Zhao J, Wang J, Tan H, Lu H, Liu F, et al. Patency of runoff detected by MR angiography at 3.0 T with cuff-compression: a predictor of successful endovascular recanalization below the knee. Eur Radiol. 2014;24:2857–65.
Collins R, Burch J, Cranny G, Aguiar-Ibáñez R, Craig D, Wright K, et al. Duplex ultrasonography, magnetic resonance angiography, and computed tomography angiography for diagnosis and assessment of symptomatic, lower limb peripheral arterial disease: systematic review. BMJ. 2007;334:1257–65.
Leiner T, Tordoir J, Kessels A, Nelemans P, Schurink G, Kitslaar P, et al. Comparison of treatment plans for peripheral arterial disease made with multi-station contrast medium-enhanced magnetic resonance angiography and duplex ultrasound scanning. J Vasc Surg. 2003;37:1255–62.
Aibinu A, Salami M, Shafie A, Najeeb A. MRI reconstruction using discrete Fourier transform: a tutorial. Inter J Comp Elec Auto Cont Info Eng. 2008;2:1852–8.
Diehm N, Kickuth R, Baumgartner I, Srivastav S, Gretener S, Husmann M, et al. Magnetic resonance angiography in infrapopliteal arterial disease: prospective comparison of 1.3 and 3 tesla magnetic resonance imaging. Investig Radiol. 2007;42:467–76.
Sharafuddin M, Stolpen A, Sun S, Leusner C, Safvi A, Hoballah J, et al. High-resolution multiphase contrast-enhanced three-dimensional MR angiography compared with two-dimensional time-of-flight MR angiography for the identification of pedal vessels. J Vasc Interv Radiol. 2002;13:695–702.
Bremerich J, Bilecon D, Reimer P. MR angiography with blood pool contrast agents. Eur Radiol. 2007;17:3017–24.
Ouwendijk R, de Vries M, Stinjen T, Pattynama P, van Sambeek M, Buth J, et al. Multicenter randomized controlled trial of the costs and effects of non-invasive diagnostic imaging in patients with peripheral arterial disease: the DIPAD trial. Am J Roentgenol. 2008;190:1349–57.
Waugh J, Sacharias N. Arteriographic complications in the DSA era. Radiology. 1992;182:243–6.
Bezooijen R, van den Bosch H, Tielbeek A, Thelissen G, Visser K, Hunick M, et al. Peripheral arterial disease: sensitivity-encoded multiposition MR angiography compared with intraarterial angiography and conventional multiposition MR angiography. Radiology. 2004;232:635–52.
Loewe C, Schoder M, Rand T, Hoffmann U, Sailer J, Kos T, et al. Peripheral vascular occlusive disease: evaluation with contrast-enhanced moving-bed MR angiography versus digital subtraction angiography in 106 patients. Am J Roentgenol. 2002;179:1013–21.
Huegli R, Aschwanden M, Bongartz G, Jaeger K, Heidecker H, Thalhammer C, et al. Intraarterial MR angiography and DSA in patients with peripheral arterial occlusive disease: prospective comparison. Radiology. 2006;239:901–8.
Meissner O, Reiger J, Weber C, Siebert U, Steckmeier B, Reiser M, et al. Critical limb ischemia: hybrid MR angiography compared with DSA. Radiology. 2005;235:308–18.
Mell M, Tefera G, Thornton F, Siepman D, Turnipseed W. Clinical utility of time-resolved imaging of contrast kinetics (TRICKS) magnetic resonance angiography for infrageniculate arterial occlusive disease. J Vasc Surg. 2007;45:543–8.
de Vos M, Hawkins A, Hevelone N, Hamming J, Nguyen L. National variation in the utilization of alternative imaging in peripheral arterial disease. J Vasc Surg. 2014;59:1315–22.
Ouwendijk R, Kock M, Visser K, Pattynama P, de Haan M, Hunink M. Interobserver agreement for interpretation of contrast-enhanced three-dimensional MR angiography and multi-detector row CT angiography in peripheral arterial disease. Am J Roentgenol. 2005;185:1261–7.
Ouwendijk R, de Vries M, Pattynama P, van Sambeek M, de Haan M, Stijnen T, et al. Contrast-enhanced three-dimensional MR angiography versus multi-detector row CT angiography in patients with peripheral arterial disease: a randomized controlled trial. Radiology. 2005;236:1094–103.
Ouwendijk R, Kock M, van Dijk L, van Sambeek M, Stijnen T, Hunink M. Vessel wall calcifications on multi-detector row CT angiography in patients with peripheral arterial disease: impact on clinical utility and clinical predictors. Radiology. 2006;241:603–8.
Jens S, Koelemay M, Reekers J, Bipat S. Diagnostic performance of computed tomography angiography and contrast-enhanced magnetic resonance angiography in patients with critical limb ischaemia and intermittent claudication: systematic review and meta-analysis. Eur Radiol. 2013;23:3104–14.
Brenner D, Hall E. Computed tomography—an increasing source of radiation exposure. N Engl J Med. 2007;357:2277–84.
Iglesias J, Peña C. Computed tomography angiography and magnetic resonance angiography imaging in critical limb ischemia: an overview. Tech Vasc Interv Radiol. 2014;17:147–54.
Visser K, Hunink M. Peripheral arterial disease: gadolinium-enhanced MR angiography versus color-guided duplex US—a meta-analysis. Radiology. 2000;216:66–77.
Thomsen H, Morcos S, Almén T, Bellin M, Berolotto M, Bongartz G, et al. Nephrogenic systemic fibrosis and gadolinium-based contrast media: updated ESUR contrast medium safety committee guidelines. Eur Radiol. 2013;23:307–18.
Bongartz G, Mayr M, Bilecen D. Magnetic resonance angiography (MRA) in renally impaired patients: when and how. Eur J Radiol. 2008;66:213–9.
Walker J, Nosova E, Sigovan M, Rapp J, Grenon M, Owens C, et al. Ferumoxytol-enhanced magnetic resonance angiography is a feasible method for the clinical evaluation of lower extremity arterial disease. Ann Vasc Surg. 2015;29:63–8.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Review Questions
Review Questions
-
1.
When did MR angiography become widely available?
-
a.
1980s
-
b.
1990s
-
c.
2000s
-
d.
2010s
-
a.
-
2.
To which gold-standard modality is MR angiography compared?
-
a.
Digital subtraction angiography
-
b.
Computed tomographic angiography
-
c.
Duplex ultrasonography
-
d.
Intravascular ultrasound
-
a.
-
3.
Which of the following is not utilized by MR angiography?
-
a.
Ionizing radiation
-
b.
Gadolinium-based contrast
-
c.
Magnetic field gradient
-
d.
Coils
-
a.
-
4.
Which of the following has been associated with the development of nephrogenic systemic fibrosis?
-
a.
Renal insufficiency
-
b.
Metabolic acidosis
-
c.
Repeated MR angiographic studies
-
d.
All of the above
-
a.
Answer Key
-
1.
b
-
2.
a
-
3.
a
-
4.
d
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Awad, N.A., Carpenter, J.P. (2017). Magnetic Resonance Angiography in the Diagnosis of Peripheral Arterial Disease. In: AbuRahma, A. (eds) Noninvasive Vascular Diagnosis. Springer, Cham. https://doi.org/10.1007/978-3-319-54760-2_62
Download citation
DOI: https://doi.org/10.1007/978-3-319-54760-2_62
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-54758-9
Online ISBN: 978-3-319-54760-2
eBook Packages: MedicineMedicine (R0)