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Metabolomics: From Fundamentals to Clinical Applications pp 265–290Cite as

Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective

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Part of the book series: Advances in Experimental Medicine and Biology ((PMISB,volume 965))

Abstract

Lipidomics is a lipid-targeted metabolomics approach aiming at comprehensive analysis of lipids in biological systems. Recent technological progresses in mass spectrometry, nuclear magnetic resonance spectroscopy, and chromatography have significantly enhanced the developments and applications of metabolic profiling of lipids in more complex biological samples. As many diseases reveal a notable change in lipid profiles compared with that of healthy people, lipidomics have also been broadly introduced to scientific research on diseases. Exploration of lipid biochemistry by lipidomics approach will not only provide insights into specific roles of lipid molecular species in health and disease, but it will also support the identification of potential biomarkers for establishing preventive or therapeutic approaches for human health. This chapter aims to illustrate how lipidomics can contribute for understanding the biological mechanisms inherent to schizophrenia and why lipids are relevant biomarkers of schizophrenia. The application of lipidomics in clinical studies has the potential to provide new insights into lipid profiling and pathophysiological mechanisms underlying schizophrenia. The future perspectives of lipidomics in mental disorders are also discussed herein.

The original version of this book was revised. An erratum to this chapter can be found at DOI 10.1007/978-3-319-47656-8_14

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-47656-8_14

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Abbreviations

AA:

Arachidonic acid

APCI:

Atmospheric pressure chemical ionization

BD:

Bipolar disorder

BMI:

Body mass index

CE:

Cholesteryl ester

Cer:

Ceramide

CNS:

Central nervous system

COX:

Cyclooxygenase

DG:

Diacylglycerol

DHA:

Docosahexaenoic acid

ELSD:

Evaporative light-scattering detector

ESI:

Electrospray ionization

FA:

Fatty acyl

FFA:

Free fatty acid

FID:

Flame ionization detector

FTICR:

Fourier transform ion cyclotron resonance

GC:

Gas chromatography

GL:

Glycerolipid

GP:

Glycerophospholipid

GPA:

Glycerophosphatidic acid

HDL:

High-density lipoprotein

hexCer:

Monohexosylceramide

HNE:

4-Hydroxynonenal

HPLC:

High-performance liquid chromatography

IM-MS:

Ion mobility-mass spectrometry

LDL:

Low-density lipoprotein

LOX:

Lipoxygenase

LPC:

Lysophosphatidylcholine

LPE:

Lysophosphatidylethanolamine

LPO:

Lipid peroxidation

MALDI:

Matrix-assisted laser desorption/ionization

MS:

Mass spectrometry

MS:

Mass spectrometry

MS/MS:

Tandem mass spectrometry

NAPS:

N-acyl-phosphatidylserine

NMR:

Nuclear magnetic resonance

NPLC:

Normal-phase liquid chromatography

PA:

Phosphatidic acid

PC:

Phosphatidylcholine

PE:

Phosphatidylethanolamine

PG:

Phosphoglycerol

PI:

Phosphatidylinositol

PK:

Polyketide

Pl:

Plasmalogen

PL:

Phospholipid

PLA2 :

Phospholipase A2 PS: Phosphatidylserine

PR:

Prenol lipid

PS:

Phosphatidylserine

PUFA:

Polyunsaturated fatty acid

Q:

Quadrupole

RBC:

Red blood cell

ROS:

Reactive oxygen species

S1P:

Sphingosine-1-phosphate

SCZ:

Schizophrenia

SL:

Saccharolipid

SM:

Sphingomyelin

SP:

Sphingolipid

SPE:

Solid-phase extraction

ST:

Sterol lipid

TG:

Triacylglycerol

TLC:

Thin-layer chromatography

TOF:

Time of flight

UPLC:

Ultra-performance liquid chromatography

VLDL:

Very low-density lipoprotein

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Acknowledgments

We thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brasília, Brazil) and Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) for their financial support and fellowship. SS received a Young Talent Scholarship from the CNPq. BSB received a scholarship from the FAPESP (2013/14707-9), and JGMP received a scholarship from the CNPq.

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Authors and Affiliations

  1. Department of Psychiatry, Federal University of São Paulo (UNIFESP), Research Building II, Rua Pedro de Toledo 669-3, Floor Funds – Vila Clementino, 04039-032, São Paulo, Brazil

    Sumit Sethi & Elisa Brietzke

  2. Department of Pharmacology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

    Mirian A. F. Hayashi

  3. Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP), Campinas, Brazil

    Banny S. Barbosa, João G. M. Pontes & Ljubica Tasic

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  1. Sumit Sethi
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  2. Mirian A. F. Hayashi
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  3. Banny S. Barbosa
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  4. João G. M. Pontes
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  5. Ljubica Tasic
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  6. Elisa Brietzke
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Corresponding author

Correspondence to Elisa Brietzke .

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Editors and Affiliations

  1. University of Campinas (UNICAMP) Institute of Chemistry Laboratory of Bioanalytics and Integrated Omics (LaBIOmics), Campinas, Brazil

    Alessandra Sussulini

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Sethi, S., Hayashi, M.A.F., Barbosa, B.S., Pontes, J.G.M., Tasic, L., Brietzke, E. (2017). Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective. In: Sussulini, A. (eds) Metabolomics: From Fundamentals to Clinical Applications. Advances in Experimental Medicine and Biology(), vol 965. Springer, Cham. https://doi.org/10.1007/978-3-319-47656-8_11

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