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Complications and Management in Laser Refractive Surface Ablation (SA)

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Complications in Corneal Laser Surgery

Abstract

This chapter gives an overview on one of the oldest, but still indispensable corneal refractive laser surgery strategy. Whereas the currently most often performed corneal refractive strategies involve the creation of corneal lamellae either on the surface (LASIK) or within the corneal stroma (SMILE®), surface ablation (SA) aims to reshape the corneal curvature by directly ablating the corneal surface. SA was the first corneal refractive treatment performed with an Excimer-laser-system and thereby completely changed the world of refractive surgery. The oldest realized SA was the photorefractive keratectomy (PRK). It pioneered the field of laser-refractive-surgery more then 30 years ago and has been approved by the United States Food and Drug Administration (US FDA) in 1995 [1, 2]. The common principle of SA strategies is to remove the corneal epithelium either solely mechanically, with the aid of alcohol or with the Excimerlaser itself (see Table 11.1). After performing the abrasio, the laser ablates the corneal tissue using an ultraviolet 193 nm wavelength beam with a mixture of argon-fluorine gas serving as the energy source. Modern Excimer-laser systems work with pulse frequencies of 200–500 Hz. The corneal tissue absorbs the emitted laser-energy, so the effect concentrates on the surface without altering the deeper layer of the cornea. The binding energy of the corneal molecules is 3.6 − 6.4 eV. During the photoablation, the laser bursts these inter-molecule-connections [3–5]. The released kinetic energy of the free protons results in a smoke emission observable during the treatment. Thus, almost no photodisruptive or thermic damage to the surrounding corneal tissue occurs [6].

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References

Therapeutic Excimer Ablation

  1. Munnerlyn CR, Koons SJ, Marshall J. Photorefractive keratectomy: a technique for laser refractive surgery. J Cataract Refract Surg. 1988;14(1):46–52.

    Article  CAS  PubMed  Google Scholar 

  2. Seiler T, Bende T, Wollensak J. Use of far UV light in photoablation of the cornea. Fortschr Ophthalmol. 1986;83(5):556–8.

    CAS  PubMed  Google Scholar 

  3. Kahle G, Stadter H, Seiler T, Wollensak J. Gas chromatographic and mass spectroscopic analysis of excimer and erbium: yttrium aluminum garnet laser-ablated human cornea. Invest Ophthalmol Vis Sci. 1992;33(7):2180–4.

    CAS  PubMed  Google Scholar 

  4. Krueger RR, Rabinowitz YS, Binder PS. The 25th anniversary of excimer lasers in refractive surgery: historical review. J Refract Surg. 2010;26(10):749–60. doi:10.3928/1081597X-20100921-01.

    Article  PubMed  Google Scholar 

  5. Puliafito CA, Stern D, Krueger RR, Mandel ER. High-speed photography of excimer laser ablation of the cornea. Arch Ophthalmol. 1987;105(9):1255–9.

    Article  CAS  PubMed  Google Scholar 

  6. Bende T, Seiler T, Wollensak J. Side effects in excimer corneal surgery. Corneal thermal gradients. Graefes Arch Clin Exp Ophthalmol. 1988;226(3):277–80.

    Article  CAS  PubMed  Google Scholar 

  7. Seiler T, McDonnell PJ. Excimer laser photorefractive keratectomy. Surv Ophthalmol. 1995;40(2):89–118.

    Article  CAS  PubMed  Google Scholar 

  8. Abad JC, An B, Power WJ, Foster CS, Azar DT, Talamo JH. A prospective evaluation of alcohol-assisted versus mechanical epithelial removal before photorefractive keratectomy. Ophthalmology. 1997;104(10):1566–74. discussion 1574–5.

    Article  CAS  PubMed  Google Scholar 

  9. Espana EM, Grueterich M, Mateo A, Romano AC, Yee SB, Yee RW, et al. Cleavage of corneal basement membrane components by ethanol exposure in laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2003;29(6):1192–7.

    Article  PubMed  Google Scholar 

  10. Sekundo W, Tietjen A. Laser-assisted subepithelial keratectomy (LasEk). Review of the current state of knowledge. Ophthalmologe. 2003;100(8):603–10. doi:10.1007/s00347-003-0853-8.

    Article  CAS  PubMed  Google Scholar 

  11. Pallikaris IG, Katsanevaki VJ, Kalyvianaki MI, Naoumidi II. Advances in subepithelial excimer refractive surgery techniques: Epi-LASIK. Curr Opin Ophthalmol. 2003;14(4):207–12.

    Article  PubMed  Google Scholar 

  12. Liu XQ, Xu L, Yi CJ. Flap removal or flap preservation during LASEK surgery. Cell Biochem Biophys. 2010;57(1):45–8. doi:10.1007/s12013-010-9082-3.

    Article  CAS  PubMed  Google Scholar 

  13. Na KS, Lee KM, Park SH, Lee HS, Joo CK. Effect of flap removal in myopic epi-LASIK surgery on visual rehabilitation and postoperative pain: a prospective intraindividual study. Ophthalmologica. 2010;224(5):325–31. doi:10.1159/000313834.

    Article  PubMed  Google Scholar 

  14. Lee YG, Chen WY, Petroll WM, Cavanagh HD, Jester JV. Corneal haze after photorefractive keratectomy using different epithelial removal techniques: mechanical debridement versus laser scrape. Ophthalmology. 2001;108(1):112–20.

    Article  CAS  PubMed  Google Scholar 

  15. Moller-Pedersen T, Cavanagh HD, Petroll WM, Jester JV. Corneal haze development after PRK is regulated by volume of stromal tissue removal. Cornea. 1998;17(6):627–39.

    Article  CAS  PubMed  Google Scholar 

  16. de Benito-Llopis L, Alio JL, Ortiz D, Teus MA, Artola A. Ten-year follow-up of excimer laser surface ablation for myopia in thin corneas. Am J Ophthalmol. 2009;147(5):768–73, 773. e761–2. doi:10.1016/j.ajo.2008.12.022.

    Article  PubMed  Google Scholar 

Complications and Management in Laser Refractive Surface Ablation (SA)

  1. Kim SY, Sah WJ, Lim YW, Hahn TW. Twenty percent alcohol toxicity on rabbit corneal epithelial cells: electron microscopic study. Cornea. 2002;21(4):388–92.

    Article  PubMed  Google Scholar 

  2. Zhang P, Liu M, Liao R. Toxic effect of using twenty percent alcohol on corneal epithelial tight junctions during LASEK. Mol Med Rep. 2012;6(1):33–8. doi:10.3892/mmr.2012.880.

    CAS  PubMed  Google Scholar 

  3. Kaufman SC. Use of photorefractive keratectomy in a patient with a corneal scar secondary to herpes zoster ophthalmicus. Ophthalmology. 2008;115(2 Suppl):S33–4. doi:10.1016/j.ophtha.2007.10.014.

    Article  PubMed  Google Scholar 

  4. Levy J, Lapid-Gortzak R, Klemperer I, Lifshitz T. Herpes simplex virus keratitis after laser in situ keratomileusis. J Refract Surg. 2005;21(4):400–2.

    PubMed  Google Scholar 

  5. Wulff K, Fechner PU. Herpes simplex keratitis after photorefractive keratectomy. J Refract Surg. 1997;13(7):613.

    CAS  PubMed  Google Scholar 

  6. Asbell PA. Valacyclovir for the prevention of recurrent herpes simplex virus eye disease after excimer laser photokeratectomy. Trans Am Ophthalmol Soc. 2000;98:285–303.

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Dhaliwal DK, Romanowski EG, Yates KA, Hu D, Mah FS, Fish DN, et al. Valacyclovir inhibition of recovery of ocular herpes simplex virus type 1 after experimental reactivation by laser in situ keratomileusis. J Cataract Refract Surg. 2001;27(8):1288–93.

    Article  CAS  PubMed  Google Scholar 

  8. Shapira Y, Mimouni M, Levartovsky S, Varssano D, Sela T, Munzer G, et al. Comparison of three epithelial removal techniques in PRK: mechanical, alcohol-assisted, and transepithelial laser. J Refract Surg. 2015;31(11):760–6. doi:10.3928/1081597X-20151021-05.

    Article  PubMed  Google Scholar 

  9. Fay J, Juthani V. Current trends in pain management after photorefractive and photo-therapeutic keratectomy. Curr Opin Ophthalmol. 2015;26(4):255–9. doi:10.1097/ICU.0000000000000170.

    Article  PubMed  Google Scholar 

  10. Kalyvianaki MI, Kymionis GD, Kounis GA, Panagopoulou SI, Grentzelos MA, Pallikaris IG. Comparison of Epi-LASIK and off-flap Epi-LASIK for the treatment of low and moderate myopia. Ophthalmology. 2008;115(12):2174–80. doi:10.1016/j.ophtha.2008.08.025.

    Article  PubMed  Google Scholar 

  11. Torres LF, Sancho C, Tan B, Padilla K, Schanzlin DJ, Chayet AS. Early postoperative pain following Epi-LASIK and photorefractive keratectomy: a prospective, comparative, bilateral study. J Refract Surg. 2007;23(2):126–32.

    PubMed  Google Scholar 

  12. Cui M, Chen XM, Lu P. Comparison of laser epithelial keratomileusis and photorefractive keratectomy for the correction of myopia: a meta-analysis. Chin Med J (Engl). 2008;121(22):2331–5.

    Google Scholar 

  13. Zhao LQ, Wei RL, Cheng JW, Li Y, Cai JP, Ma XY. Meta-analysis: clinical outcomes of laser-assisted subepithelial keratectomy and photorefractive keratectomy in myopia. Ophthalmology. 2010;117(10):1912–22. doi:10.1016/j.ophtha.2010.02.004.

    Article  PubMed  Google Scholar 

  14. Eliacik M, Bayramlar H, Erdur SK, Karabela Y, Demirci G, Gulkilik IG, et al. Anterior segment optical coherence tomography evaluation of corneal epithelium healing time after 2 different surface ablation methods. Saudi Med J. 2015;36(1):67–72. doi:10.15537/smj.2015.1.9983.

    Article  PubMed  PubMed Central  Google Scholar 

  15. McAlvin JB, Zhan C, Dohlman JC, Kolovou PE, Salvador-Culla B, Kohane DS. Corneal anesthesia with site 1 sodium channel blockers and dexmedetomidine. Invest Ophthalmol Vis Sci. 2015;56(6):3820–6. doi:10.1167/iovs.15-16591.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Wang L, Shankarappa SA, Tong R, Ciolino JB, Tsui JH, Chiang HH, et al. Topical drug formulations for prolonged corneal anesthesia. Cornea. 2013;32(7):1040–5. doi:10.1097/ICO.0b013e31828cbfe6.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Grant RL, Acosta D. Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res. 1994;58(4):469–78. doi:10.1006/exer.1994.1040.

    Article  CAS  PubMed  Google Scholar 

  18. McGee HT, Fraunfelder FW. Toxicities of topical ophthalmic anesthetics. Expert Opin Drug Saf. 2007;6(6):637–40. doi:10.1517/14740338.6.6.637.

    Article  CAS  PubMed  Google Scholar 

  19. Verma S, Corbett MC, Marshall J. A prospective, randomized, double-masked trial to evaluate the role of topical anesthetics in controlling pain after photorefractive keratectomy. Ophthalmology. 1995;102(12):1918–24.

    Article  CAS  PubMed  Google Scholar 

  20. Shahinian Jr L, Jain S, Jager RD, Lin DT, Sanislo SS, Miller JF. Dilute topical proparacaine for pain relief after photorefractive keratectomy. Ophthalmology. 1997;104(8):1327–32.

    Article  PubMed  Google Scholar 

  21. Lee JK, Stark WJ. Anesthetic keratopathy after photorefractive keratectomy. J Cataract Refract Surg. 2008;34(10):1803–5. doi:10.1016/j.jcrs.2008.04.051.

    Article  PubMed  Google Scholar 

  22. Rao SK, Wong VW, Cheng AC, Lam PT, Lam DS. Topical anesthesia-induced keratopathy after laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2007;33(8):1482–4. doi:10.1016/j.jcrs.2007.04.020.

    Article  PubMed  Google Scholar 

  23. Yagci A, Bozkurt B, Egrilmez S, Palamar M, Ozturk BT, Pekel H. Topical anesthetic abuse keratopathy: a commonly overlooked health care problem. Cornea. 2011;30(5):571–5.

    Article  PubMed  Google Scholar 

  24. Faktorovich EG, Basbaum AI. Effect of topical 0.5% morphine on postoperative pain after photorefractive keratectomy. J Refract Surg. 2010;26(12):934–41. doi:10.3928/1081597X-20100212-06.

    Article  PubMed  Google Scholar 

  25. Zollner C, Mousa S, Klinger A, Forster M, Schafer M. Topical fentanyl in a randomized, double-blind study in patients with corneal damage. Clin J Pain. 2008;24(8):690–6. doi:10.1097/AJP.0b013e318175929e.

    Article  PubMed  Google Scholar 

  26. Donnenfeld ED, Holland EJ, Durrie DS, Raizman MB. Double-masked study of the effects of nepafenac 0.1% and ketorolac 0.4% on corneal epithelial wound healing and pain after photorefractive keratectomy. Adv Ther. 2007;24(4):852–62.

    Article  CAS  PubMed  Google Scholar 

  27. Durrie DS, Kennard MG, Boghossian AJ. Effects of nonsteroidal ophthalmic drops on epithelial healing and pain in patients undergoing bilateral photorefractive keratectomy (PRK). Adv Ther. 2007;24(6):1278–85.

    Article  CAS  PubMed  Google Scholar 

  28. Faktorovich EG, Melwani K. Efficacy and safety of pain relief medications after photorefractive keratectomy: review of prospective randomized trials. J Cataract Refract Surg. 2014;40(10):1716–30. doi:10.1016/j.jcrs.2014.08.001.

    Article  PubMed  Google Scholar 

  29. Edwards JD, Bower KS, Sediq DA, Burka JM, Stutzman RD, Vanroekel CR, et al. Effects of lotrafilcon A and omafilcon A bandage contact lenses on visual outcomes after photorefractive keratectomy. J Cataract Refract Surg. 2008;34(8):1288–94. doi:10.1016/j.jcrs.2008.04.024.

    Article  PubMed  Google Scholar 

  30. Wroblewski KJ, Pasternak JF, Bower KS, Schallhorn SC, Hubickey WJ, Harrison CE, et al. Infectious keratitis after photorefractive keratectomy in the United States army and navy. Ophthalmology. 2006;113(4):520–5. doi:10.1016/j.ophtha.2005.09.038.

    Article  PubMed  Google Scholar 

  31. de Oliveira GC, Solari HP, Ciola FB, Lima AL, Campos MS. Corneal infiltrates after excimer laser photorefractive keratectomy and LASIK. J Refract Surg. 2006;22(2):159–65.

    PubMed  Google Scholar 

  32. Haq Z, Farooq AV, Huang AJ. Infections after refractive surgery. Curr Opin Ophthalmol. 2016. doi:10.1097/ICU.0000000000000275.

    PubMed  Google Scholar 

  33. Ortega-Usobiaga J, Llovet-Osuna F, Djodeyre MR, Llovet-Rausell A, Beltran J, Baviera J. Incidence of corneal infections after laser in situ keratomileusis and surface ablation when moxifloxacin and tobramycin are used as postoperative treatment. J Cataract Refract Surg. 2015;41(6):1210–6. doi:10.1016/j.jcrs.2014.09.041.

    Article  PubMed  Google Scholar 

  34. Donnenfeld ED, O’Brien TP, Solomon R, Perry HD, Speaker MG, Wittpenn J. Infectious keratitis after photorefractive keratectomy. Ophthalmology. 2003;110(4):743–7. doi:10.1016/S0161-6420(02)01936-X.

    Article  PubMed  Google Scholar 

  35. Kothari SG, Kothari RS. Successful treatment of fusarium keratitis after photo refractive keratectomy. Indian J Ophthalmol. 2014;62(5):661. doi:10.4103/0301-4738.133526.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Rodriguez B, Holzinger KA, Le LH, Winkle RK, Allen RD. Mycobacterium chelonae keratitis after laser-assisted subepithelial keratectomy. J Cataract Refract Surg. 2006;32(6):1059–61. doi:10.1016/j.jcrs.2006.03.011.

    Article  PubMed  Google Scholar 

  37. Teal P, Breslin C, Arshinoff S, Edmison D. Corneal subepithelial infiltrates following excimer laser photorefractive keratectomy. J Cataract Refract Surg. 1995;21(5):516–8.

    Article  CAS  PubMed  Google Scholar 

  38. Lahners WJ, Hardten DR, Lindstrom RL. Peripheral keratitis following laser in situ keratomileusis. J Refract Surg. 2003;19(6):671–5.

    PubMed  Google Scholar 

  39. Lifshitz T, Levy J, Mahler O, Levinger S. Peripheral sterile corneal infiltrates after refractive surgery. J Cataract Refract Surg. 2005;31(7):1392–5. doi:10.1016/j.jcrs.2004.12.057.

    Article  PubMed  Google Scholar 

  40. Yu EY, Rao SK, Cheng AC, Law RW, Leung AT, Lam DS. Bilateral peripheral corneal infiltrates after simultaneous myopic laser in situ keratomileusis. J Cataract Refract Surg. 2002;28(5):891–4.

    Article  PubMed  Google Scholar 

  41. Al-Amry MA. Severe bilateral paralimbal sterile infiltrates after photorefractive keratectomy. Middle East Afr J Ophthalmol. 2014;21(1):83–5. doi:10.4103/0974-9233.124114.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Gabison EE, Chastang P, Menashi S, Mourah S, Doan S, Oster M, et al. Late corneal perforation after photorefractive keratectomy associated with topical diclofenac: involvement of matrix metalloproteinases. Ophthalmology. 2003;110(8):1626–31. doi:10.1016/S0161-6420(03)00486-X.

    Article  PubMed  Google Scholar 

  43. Mian SI, Gupta A. Pineda 2nd R. Corneal ulceration and perforation with ketorolac tromethamine (Acular) use after PRK. Cornea. 2006;25(2):232–4.

    Article  PubMed  Google Scholar 

  44. Marshall J, Trokel SL, Rothery S, Krueger RR. Long-term healing of the central cornea after photorefractive keratectomy using an excimer laser. Ophthalmology. 1988;95(10):1411–21.

    Article  CAS  PubMed  Google Scholar 

  45. Corbett MC, O’Brart DP, Patmore AL, Marshall J. Effect of collagenase inhibitors on corneal haze after PRK. Exp Eye Res. 2001;72(3):253–9. doi:10.1006/exer.2000.0959.

    Article  CAS  PubMed  Google Scholar 

  46. Wilson SE, Chaurasia SS, Medeiros FW. Apoptosis in the initiation, modulation and termination of the corneal wound healing response. Exp Eye Res. 2007;85(3):305–11. doi:10.1016/j.exer.2007.06.009.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Chaurasia SS, Kaur H, de Medeiros FW, Smith SD, Wilson SE. Dynamics of the expression of intermediate filaments vimentin and desmin during myofibroblast differentiation after corneal injury. Exp Eye Res. 2009;89(2):133–9. doi:10.1016/j.exer.2009.02.022.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Martinez-Garcia MC, Merayo-Lloves J, Blanco-Mezquita T, Mar-Sardana S. Wound healing following refractive surgery in hens. Exp Eye Res. 2006;83(4):728–35. doi:10.1016/j.exer.2006.02.017.

    Article  CAS  PubMed  Google Scholar 

  49. Alio JL, Javaloy J. Corneal inflammation following corneal photoablative refractive surgery with excimer laser. Surv Ophthalmol. 2013;58(1):11–25. doi:10.1016/j.survophthal.2012.04.005.

    Article  PubMed  Google Scholar 

  50. Lin N, Yee SB, Mitra S, Chuang AZ, Yee RW. Prediction of corneal haze using an ablation depth/corneal thickness ratio after laser epithelial keratomileusis. J Refract Surg. 2004;20(6):797–802.

    PubMed  Google Scholar 

  51. Diakonis VF, Kankariya VP, Kymionis GD, Kounis G, Kontadakis G, Gkenos E, et al. Long term followup of photorefractive keratectomy with adjuvant use of mitomycin C. J Ophthalmol. 2014;2014:821920. doi:10.1155/2014/821920.

    PubMed  PubMed Central  Google Scholar 

  52. Ghoreishi M, Attarzadeh H, Zandi A, Moini HA, Tavakoli M, Fesharaki H, et al. Outcomes of photorefractive keratectomy with intraoperative mitomycin-C. J Ophthalmic Vis Res. 2009;4(3):142–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  53. Nassaralla BA, McLeod SD, Nassaralla Jr JJ. Prophylactic mitomycin C to inhibit corneal haze after photorefractive keratectomy for residual myopia following radial keratotomy. J Refract Surg. 2007;23(3):226–32.

    PubMed  Google Scholar 

  54. Tomás-Juan J, Murueta-Goyena Larranaga A, Hanneken L. Corneal regeneration after photorefractive keratectomy: a review. J Optom. 2015;8(3):149–69. doi:10.1016/j.optom.2014.09.001.

    Article  PubMed  Google Scholar 

  55. Teus MA, de Benito-Llopis L, Alio JL. Mitomycin C in corneal refractive surgery. Surv Ophthalmol. 2009;54(4):487–502. doi:10.1016/j.survophthal.2009.04.002.

    Article  PubMed  Google Scholar 

  56. Blanco-Mezquita T, Espandar L, Torres R, Alvarez-Barcia A, Cantalapiedra-Rodriguez R, Martinez-Garcia C, et al. Does mitomycin C cause toxicity in the cornea after photorefractive keratectomy? A comparative wound-healing study in a refractive surgery animal model. Cornea. 2014;33(11):1225–31. doi:10.1097/ICO.0000000000000219.

    Article  PubMed  Google Scholar 

  57. Thornton I, Xu M, Krueger RR. Comparison of standard (0.02%) and low dose (0.002%) mitomycin C in the prevention of corneal haze following surface ablation for myopia. J Refract Surg. 2008;24(1):S68–76.

    PubMed  Google Scholar 

  58. de Medeiros FW, Mohan RR, Suto C, Sinha S, Bonilha VL, Chaurasia SS, et al. Haze development after photorefractive keratectomy: mechanical vs ethanol epithelial removal in rabbits. J Refract Surg. 2008;24(9):923–7.

    PubMed  Google Scholar 

  59. Einollahi B, Baradaran-Rafii A, Rezaei-Kanavi M, Eslani M, Parchegani MR, Zare M, et al. Mechanical versus alcohol-assisted epithelial debridement during photorefractive keratectomy: a confocal microscopic clinical trial. J Refract Surg. 2011;27((12):887–93. doi:10.3928/1081597X-20110823-02.

    Article  PubMed  Google Scholar 

  60. Lee HK, Lee KS, Kim JK, Kim HC, Seo KR, Kim EK. Epithelial healing and clinical outcomes in excimer laser photorefractive surgery following three epithelial removal techniques: mechanical, alcohol, and excimer laser. Am J Ophthalmol. 2005;139(1):56–63. doi:10.1016/j.ajo.2004.08.049.

    Article  PubMed  Google Scholar 

  61. Carones F, Fiore T, Brancato R. Mechanical vs. alcohol epithelial removal during photorefractive keratectomy. J Refract Surg. 1999;15(5):556–62.

    CAS  PubMed  Google Scholar 

  62. Korkmaz S, Bilgihan K, Sul S, Hondur A. A clinical and confocal microscopic comparison of transepithelial PRK and LASEK for myopia. J Ophthalmol. 2014;2014:784185. doi:10.1155/2014/784185.

    PubMed  PubMed Central  Google Scholar 

  63. Sia RK, Ryan DS, Edwards JD, Stutzman RD, Bower KS. The U.S. Army Surface Ablation Study: comparison of PRK, MMC-PRK, and LASEK in moderate to high myopia. J Refract Surg. 2014;30(4):256–64. doi:10.3928/1081597X-20140320-04.

    Article  PubMed  Google Scholar 

  64. Pallikaris IG, Kalyvianaki MI, Katsanevaki VJ, Ginis HS. Epi-LASIK: preliminary clinical results of an alternative surface ablation procedure. J Cataract Refract Surg. 2005;31(5):879–85. doi:10.1016/j.jcrs.2004.09.052.

    Article  PubMed  Google Scholar 

  65. Qazi MA, Johnson TW, Pepose JS. Development of late-onset subepithelial corneal haze after laser-assisted subepithelial keratectomy with prophylactic intraoperative mitomycin-C Case report and literature review. J Cataract Refract Surg. 2006;32(9):1573–8. doi:10.1016/j.jcrs.2006.04.027.

    Article  PubMed  Google Scholar 

  66. Kim JK, Kim SS, Lee HK, Lee IS, Seong GJ, Kim EK, et al. Laser in situ keratomileusis versus laser-assisted subepithelial keratectomy for the correction of high myopia. J Cataract Refract Surg. 2004;30(7):1405–11. doi:10.1016/j.jcrs.2003.12.053.

    Article  PubMed  Google Scholar 

  67. Lipshitz I, Loewenstein A, Varssano D, Lazar M. Late onset corneal haze after photorefractive keratectomy for moderate and high myopia. Ophthalmology. 1997;104(3):369–73. discussion 373–4.

    Article  CAS  PubMed  Google Scholar 

  68. Kuo IC, Lee SM, Hwang DG. Late-onset corneal haze and myopic regression after photorefractive keratectomy (PRK). Cornea. 2004;23(4):350–5.

    Article  PubMed  Google Scholar 

  69. Alio JL, Artola A, Claramonte PJ, Ayala MJ, Sanchez SP. Complications of photorefractive keratectomy for myopia: two year follow-up of 3000 cases. J Cataract Refract Surg. 1998;24(5):619–26.

    Article  CAS  PubMed  Google Scholar 

  70. Carones F, Vigo L, Scandola E, Vacchini L. Evaluation of the prophylactic use of mitomycin-C to inhibit haze formation after photorefractive keratectomy. J Cataract Refract Surg. 2002;28(12):2088–95.

    Article  PubMed  Google Scholar 

  71. Rajan MS, O’Brart D, Jaycock P, Marshall J. Effects of ablation diameter on long-term refractive stability and corneal transparency after photorefractive keratectomy. Ophthalmology. 2006;113(10):1798–806. doi:10.1016/j.ophtha.2006.06.030.

    Article  PubMed  Google Scholar 

  72. Kim JH, Sah WJ, Kim MS, Lee YC, Park CK. Three-year results of photorefractive keratectomy for myopia. J Refract Surg. 1995;11(3 Suppl):S248–52.

    CAS  PubMed  Google Scholar 

  73. Tengroth B, Epstein D, Fagerholm P, Hamberg-Nystrom H, Fitzsimmons TD. Excimer laser photorefractive keratectomy for myopia. Clinical results in sighted eyes. Ophthalmology. 1993;100(5):739–45.

    Article  CAS  PubMed  Google Scholar 

  74. O’Brart DP. Excimer laser surface ablation: a review of recent literature. Clin Exp Optom. 2014;97(1):12–7. doi:10.1111/cxo.12061.

    Article  PubMed  Google Scholar 

  75. Reynolds A, Moore JE, Naroo SA, Moore CB, Shah S. Excimer laser surface ablation – a review. Clin Experiment Ophthalmol. 2010;38(2):168–82. doi:10.1111/j.1442-9071.2010.02230.x.

    Article  PubMed  Google Scholar 

  76. Manche EE, Haw WW. Wavefront-guided laser in situ keratomileusis (Lasik) versus wavefrontguided photorefractive keratectomy (Prk): a prospective randomized eye-to-eye comparison (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc. 2011;109:201–20.

    PubMed  PubMed Central  Google Scholar 

  77. McAlinden C, Skiadaresi E, Moore JE. Hyperopic LASEK treatments with mitomycin C using the SCHWIND AMARIS. J Refract Surg. 2011;27(5):380–3. doi:10.3928/1081597X-20101104-01.

    Article  PubMed  Google Scholar 

  78. Moshirfar M, Schliesser JA, Chang JC, Oberg TJ, Mifflin MD, Townley R, et al. Visual outcomes after wavefront-guided photorefractive keratectomy and wavefrontguided laser in situ keratomileusis: prospective comparison. J Cataract Refract Surg. 2010;36(8):1336–43. doi:10.1016/j.jcrs.2010.02.012.

    Article  PubMed  Google Scholar 

  79. Settas G, Settas C, Minos E, Yeung IY. Photorefractive keratectomy (PRK) versus laser assisted in situ keratomileusis (LASIK) for hyperopia correction. Cochrane Database Syst Rev. 2012;6, CD007112. doi:10.1002/14651858.CD007112.pub3.

    Google Scholar 

  80. Dirani M, Couper T, Yau J, Ang EK, Islam FM, Snibson GR, et al. Long-term refractive outcomes and stability after excimer laser surgery for myopia. J Cataract Refract Surg. 2010;36(10):1709–17. doi:10.1016/j.jcrs.2010.04.041.

    Article  PubMed  Google Scholar 

  81. Katz T, Wagenfeld L, Galambos P, Darrelmann BG, Richard G, Linke SJ. LASIK versus photorefractive keratectomy for high myopic (> 3 diopter) astigmatism. J Refract Surg. 2013;29(12):824–31. doi:10.3928/1081597X-20131029-03.

    Article  PubMed  Google Scholar 

  82. Kirwan C, O’Keefe M. Comparative study of higher-order aberrations after conventional laser in situ keratomileusis and laser epithelial keratomileusis for myopia using the technolas 217z laser platform. Am J Ophthalmol. 2009;147(1):77–83. doi:10.1016/j.ajo.2008.07.014.

    Article  PubMed  Google Scholar 

  83. O’Brart DP, Mellington F, Jones S, Marshall J. Laser epithelial keratomileusis for the correction of hyperopia using a 7.0-mm optical zone with the Schwind ESIRIS laser. J Refract Surg. 2007;23(4):343–54.

    PubMed  Google Scholar 

  84. Ang RT, Dartt DA, Tsubota K. Dry eye after refractive surgery. Curr Opin Ophthalmol. 2001;12(4):318–22.

    Article  CAS  PubMed  Google Scholar 

  85. Bower KS, Sia RK, Ryan DS, Mines MJ, Dartt DA. Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: manifestations, incidence, and predictive factors. J Cataract Refract Surg. 2015;41(12):2624–34. doi:10.1016/j.jcrs.2015.06.037.

    Article  PubMed  Google Scholar 

  86. Quinto GG, Camacho W, Behrens A. Postrefractive surgery dry eye. Curr Opin Ophthalmol. 2008;19(4):335–41. doi:10.1097/ICU.0b013e3283009ef8.

    Article  PubMed  Google Scholar 

  87. Beheshtnejad AH, Hashemian H, Kermanshahani AM, Mahmoudi A, Johari MK. Evaluation of tear osmolarity changes after photorefractive keratectomy. Cornea. 2015;34(12):1541–4. doi:10.1097/ICO.0000000000000649.

    Article  PubMed  Google Scholar 

  88. Murakami Y, Manche EE. Prospective, randomized comparison of self-reported postoperative dry eye and visual fluctuation in LASIK and photorefractive keratectomy. Ophthalmology. 2012;119(11):2220–4. doi:10.1016/j.ophtha.2012.06.013.

    Article  PubMed  Google Scholar 

  89. Sia RK, Ryan DS, Stutzman RD, Psolka M, Mines MJ, Wagner ME, et al. Alcohol versus brush PRK: visual outcomes and adverse effects. Lasers Surg Med. 2012;44(6):475–81. doi:10.1002/lsm.22036.

    Article  PubMed  Google Scholar 

  90. Farahi A, Hashemi H, Mehravaran S, Tavakolizadeh S, Khabazkhoob M. Tear function evaluation in candidates of corneal laser refractive surgery for myopia. Eye Contact Lens. 2014;40(2):91–4. doi:10.1097/ICL.0000000000000015.

    Article  PubMed  Google Scholar 

  91. Torricelli AA, Bechara SJ, Wilson SE. Screening of refractive surgery candidates for LASIK and PRK. Cornea. 2014;33(10):1051–5. doi:10.1097/ICO.0000000000000171.

    Article  PubMed  Google Scholar 

  92. Salib GM, McDonald MB, Smolek M. Safety and efficacy of cyclosporine 0.05% drops versus unpreserved artificial tears in dry-eye patients having laser in situ keratomileusis. J Cataract Refract Surg. 2006;32(5):772–8. doi:10.1016/j.jcrs.2005.10.034.

    Article  PubMed  Google Scholar 

  93. Toda I, Yagi Y, Hata S, Itoh S, Tsubota K. Excimer laser photorefractive keratectomy for patients with contact lens intolerance caused by dry eye. Br J Ophthalmol. 1996;80(7):604–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Steinberg, J., Linke, S.J. (2016). Complications and Management in Laser Refractive Surface Ablation (SA). In: Linke, S., Katz, T. (eds) Complications in Corneal Laser Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-41496-6_11

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