Abstract
To infect, a virion must first encounter a bacterium, where “encounter” essentially is a euphemism for “collision.” That is, a virion must physically touch a target bacterium to enable attachment. Indeed, phage acquisition of a bacterium to infect typically will consist of a combination of virion movement (including but not exclusively via diffusion), virion encounter with a target bacterium, virion reversible attachment to that bacterium, subsequent irreversible attachment, and then phage-genome translocation into a bacterium’s cytoplasm. Many of these concepts often are lumped under the heading of phage adsorption, and in this chapter we review these various aspects of phage adsorption/acquisition of bacteria. As companion chapters covering what happens either following or because of phage adsorption, see also chapters “Phage Infection and Lysis,” “Bacteriophage Ecology,” and “Bacteriophage Pharmacology and Immunology”.
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Acknowledgments
JJD acknowledges financial support from the National Institutes of Health NIGMS through grant number 1R01GM124446-01. We also appreciate discussions with Ian Molineux and Dennis Bamford about phage infection mechanisms.
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Dennehy, J.J., Abedon, S.T. (2020). Adsorption: Phage Acquisition of Bacteria. In: Harper, D., Abedon, S., Burrowes, B., McConville, M. (eds) Bacteriophages. Springer, Cham. https://doi.org/10.1007/978-3-319-40598-8_2-1
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