Abstract
The central nervous system plays a key and important role in regulating dietary energy consumption. Studies in the literature have shown that high calorie intake is deleterious to the physiological function of neurons. On the other hand, low-calorie intake has demonstrated to be beneficial, protecting neurons against harmful effects that could lead to the development of neurodegeneration. This chapter aimed to review the main aspects of dietary energy restriction protocols, such as intermittent fasting and calorie restriction, in relation to neuronal plasticity, cognition, and neurodegeneration.
Abbreviations
- Aβ:
-
Amyloid-β peptide
- AD:
-
Alzheimer’s disease
- ADAM10:
-
A disintegrin and metalloproteinase 10
- APP:
-
Amyloid precursor protein
- BDNF:
-
Brain-derived neurotrophic factor
- CaM:
-
Ca2+/calmodulin-sensitive
- CNS:
-
Central nervous system
- CR:
-
Caloric restriction
- CREB:
-
Cyclic AMP response element-binding protein
- DAT:
-
Dopamine active transporter
- DER:
-
Dietary energy restriction
- DG:
-
Dentate gyrus
- FOXO:
-
Forkhead box O
- GDNF:
-
Glial cell line-derived neurotrophic factor
- Grp78:
-
Glucose-regulated protein 78
- GLUT3:
-
Glucose transporter 3
- HO1:
-
Heme oxygenase 1
- Hsp70:
-
Heat-shock protein 70
- IF:
-
Intermittent fasting
- LPS:
-
Lipopolysaccharide
- MPTP:
-
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- MWM:
-
Morris water maze
- NF-κB:
-
Nuclear factor κB
- NMDAR:
-
N-Methyl-D-aspartate receptor
- PD:
-
Parkinson’s disease
- PGC-1α:
-
Peroxisome proliferator-activated receptor gamma coactivator 1-α
- PPARs:
-
Peroxisome proliferator-activated receptors
- ROS:
-
Reactive oxygen species
- SIRT:
-
Sirtuin
- SN:
-
Substantia nigra
- SOD2:
-
Superoxide dismutase 2
- TrkB:
-
Tropomyosin receptor kinase B
- VMAT:
-
Vesicular monoamine transporter
- VTA:
-
Ventral tegmental area
- WHO:
-
World Health Organization
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Vasconcelos, A.R., Orellana, A.M.M., Paixão, A.G., Scavone, C., Kawamoto, E.M. (2018). Intermittent Fasting and Caloric Restriction: Neuroplasticity and Neurodegeneration. In: Preedy, V., Patel, V. (eds) Handbook of Famine, Starvation, and Nutrient Deprivation. Springer, Cham. https://doi.org/10.1007/978-3-319-40007-5_99-1
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DOI: https://doi.org/10.1007/978-3-319-40007-5_99-1
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