Definition
Castleman disease (CD) was first described by Benjamin Castleman in 1954 and consists of a heterogeneous group of disorders that share similar histomorphologic features and are clinically separated into two broad categories: unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD). UCD patients present with a single enlarged lymph node or a tightly localized group of lymph nodes, while MCD patients typically present with multifocal lymphadenopathy associated with systemic symptoms including fatigue, fever, night sweats, and weight loss. UCD can further be divided into two or three morphologic variants: the hyaline vascular variant and plasma cell variant, with some texts including a mixed variant. Patients with the hyaline vascular variant of UCD typically lack systemic symptoms, while those with the plasmacytic variant often present with systemic symptoms...
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References and Further Reading
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Astle, J.M., Lim, M.S., Elenitoba-Johnson, K.S. (2018). Castleman Disease. In: van Krieken, J. (eds) Encyclopedia of Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-28845-1_3851-1
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DOI: https://doi.org/10.1007/978-3-319-28845-1_3851-1
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