Skip to main content
SpringerLink
Log in

Cliniporator: Medical Electroporation of Tumors

  • Living reference work entry
  • First Online:
Handbook of Electroporation

Abstract

The development of the medical device Cliniporator™ started in 2000 with the homonymous European project, and, at its end, the prototype of the device was ready to be certified. The work done up to that moment has been used for a new European project called European Standard Operating Procedures for the Electrochemotherapy and Electrogenetherapy (ESOPE). During the ESOPE project, standard operating procedures (SOP) have been established, and the certified device has been used for clinical trials. Some years after the end of this project, a technological redesign of the device enhanced its capability giving the possibility to produce two different models of the device, one for gene therapy and small internal or superficial tumors and the other for big, deep, solid tumors. Both the devices are driven using the same type of pulses. What is mainly changed from the beginning is the technology used to control the device, the user interface technology, and the new types of electrodes allowing to approach different type of tumors in different locations of the body. The ability to operate during open surgery has required the capability to stay synchronized with the absolute refractory period of the heart. On the other side, the need to treat big deep tumors also required the development of accessory tools to help the surgeon to plan the intervention optimizing the number of electrodes to be used and their placement.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • André F, Mir LM (2004) DNA electrotransfer: its principles and an updated review of its therapeutic applications. Gene Ther 11(1):S33–S42

    Article  Google Scholar 

  • Cadossi R, Ronchetti M, Cadossi M (2014) Locally enhanced chemotherapy by electroporation: clinical experiences and perspective of use of electrochemotherapy. Futur Oncol 10:877–890

    Article  Google Scholar 

  • COUNCIL DIRECTIVE 93/42/EEC of 14 June 1993 concerning medical devices

    Google Scholar 

  • Cukjati D, Batiuskaite D, André F et al (2007) Real time electroporation control for accurate and safe in vivo nonviral gene therapy. Bioelectrochemistry 70(2):501–507

    Article  Google Scholar 

  • EN 60601-1:2006/A1:2013. Medical electrical equipment Part 1: General requirements for basic safety and essential performance

    Google Scholar 

  • EN 60601-1-6:2010. Medical electrical equipment – Part 1–6: General requirements for basic safety and essential performance – Collateral standard: Usability

    Google Scholar 

  • Fini M, Tschon M, Ronchetti M et al (2010) Ablation of bone cells by electroporation. J Bone Joint Surg Br 92(11):1614–1620

    Article  Google Scholar 

  • Kranjc M, Markelc B, Bajd F, Čemažar M, Serša I, Blagus T, Miklavčič D (2015) In situ monitoring of electric field distribution in mouse tumor during electroporation. Radiology 274:115–123

    Article  Google Scholar 

  • Marty M, Sersa G, Garbaya JR et al (2006) Electrochemotherapy – an easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. EJC Suppl 4(11):3–13

    Article  Google Scholar 

  • Miklavčič D, Semrov D, Mekid H et al (2000) A validated model of in vivo electric field distribution in tissues for electrochemotherapy and for DNA electrotransfer for gene therapy. Biochim Biophys Acta 1523(1):73–83

    Article  Google Scholar 

  • Miklavčič D, Pavšelj N, Hart FX (2006a) Electric properties of tissues. Wiley encyclopedia of biomedical engineering. Wiley, New York, pp 3578–3589

    Google Scholar 

  • Miklavčič D, Corovic S, Pucihar G et al (2006b) Importance of tumour coverage by sufficiently high local electric field for effective electrochemotherapy. Eur J Cancer Suppl 4(11):45–51

    Article  Google Scholar 

  • Mir LM, Orlowski S, Belehradek J Jr et al (1991a) Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer 27(1):68–72

    Article  Google Scholar 

  • Mir LM, Glass LF, Sersa G et al (1998) Effective treatment of cutaneous and subcutaneous malignant tumours by electrochemotherapy. Br J Cancer 77:2336–2342

    Article  Google Scholar 

  • Mir LM, Gehl J, Sersa G et al (2006) Standard operating procedures of the electrochemotherapy: instructions for the use of bleomycin or cisplatin administered either systemically or locally and electric pulses delivered by the CliniporatorTM by means of invasive or non-invasive electrodes. EJC Suppl 4:14–25

    Article  Google Scholar 

  • Neumann E, Rosenheck K (1972) Permeability changes induced by electric impulses in vesicular membranes. J Membr Biol 10:279–290

    Article  Google Scholar 

  • Ongaro A et al (2011) Identification of in vitro electropermeabilization equivalent pulse protocols. Technol Cancer Res Treat 10(5):465–473

    Google Scholar 

  • Project reference: QLK3-CT-1999-00484QLK3-CT-1999-00484. Cliniporator: a new adaptative generator for dna electrotransfer in vivo for gene Therapy. Available via DIALOG. http://cordis.europa.eu/project/rcn/51516_en.html

  • Project reference: QLK3-CT-2002-02003. European standard operating procedures for electrochemotherapy and electrogenetherapy Available via DIALOG. http://cordis.europa.eu/project/rcn/67434_en.html

  • Šatkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavčič D, Mir LM (2002) Mechanisms of in vivo DNA electrotransfer: respective contributions of cell electropermeabilization and DNA electrophoresis. Mol Ther 5:133–140

    Article  Google Scholar 

  • Šatkauskas S, André F, Bureau MF, Scherman D, Miklavčič D, Mir LM (2005) Electrophoretic component of electric pulses determines the efficacy of in vivo DNA electrotransfer. Hum Gene Ther 16:1194–1201

    Article  Google Scholar 

  • Serša G, Čemažar M, Miklavčič D (1995) Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res 55:3450–3455

    Google Scholar 

  • Sersa G, Micklavcic D, Cemazar M et al (2008) Electrochemotherapy in treatment of tumors. Eur J Surg Oncol 34:232–240

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Igea S.p.A., Carpi, Italy

    Claudio Bertacchini

Authors
  1. Claudio Bertacchini
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Claudio Bertacchini .

Editor information

Editors and Affiliations

  1. Faculty of Electrical Enginer, University of Ljubljana, Ljubljana, Slovenia

    Damijan Miklavcic

Section Editor information

  1. Leibniz Institute for Plasma Science and Technology, Felix-Hausdorff-Strasse 2, Greifswald, 17489, Greifswald, Germany

    Juergen F. Kolb

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this entry

Cite this entry

Bertacchini, C. (2017). Cliniporator: Medical Electroporation of Tumors. In: Miklavcic, D. (eds) Handbook of Electroporation. Springer, Cham. https://doi.org/10.1007/978-3-319-26779-1_214-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-26779-1_214-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-26779-1

  • Online ISBN: 978-3-319-26779-1

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Societies and partnerships

Search

Navigation