Abstract
The pattern of ion substitutions and non-stoichiometry of oxalate and phosphate human body minerals (weddellite, whewellite, hydroxyapatite, struvite, and brushite) and their synthetic analogs was investigated by complex X-ray diffraction, spectroscopic, and chemical methods. All the studied biological minerals are characterized by variable non-stoichiometry composition that reflects the non- stationarity of formation conditions. Non-stoichiometry of calcium oxalates results from variations in quantities of disorderly distributed water molecules. The water amount in weddellite significantly influences the crystal structure parameters. In particular, there is positive correlation between the value of a parameter and the occupancy of “zeolitic” water sites. Variations in composition of calcium and magnesium phosphates are caused by substitutions at all the crystallographic sites. Ion replacements in apatite and struvite are more prominent in comparison with those in brushite. Non-stoichiometry of apatite and brushite is due to the presence of vacancies at the Ca-sites, and that of struvite is due to the vacancies at the Mg-site. Two types of non-stoichiometry in carbonated apatites of B-type realize due to replacements PO4 3− ← CO3 2− or OH− ← H2O. Maximum concentrations of impurity ions in magnesium and calcium phosphates are mainly limited by the content of these ions in the physiological solution. In case of Mg replacement with Ca in struvite and Ca with K in brushite and apatite, it is also essentially limited by the size differences of the host and admixture ions.
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References
Akselrud LG, Grin YuN, Pecharsky VK, Zavaliy PY et al (1993) Use of the CSD program package for structure determination from powder data. In: Proceedings of 2nd Europe powder diffraction conference Pt 1. Enschede, Trans Tech Pub, The Netherlands
Benramdane L, Bouatia M, Idrissi MOB, Draoui M (2008) Infrared analysis of urinary stones, using a single reflection accessory and a KBr pellet transmission. Spectrosc Lett 41(2):72–80
Conti C, Brambilla L, Colombo C, Dellasega D, Diego GG, Realinia M, Zerbib G (2010) Stability and transformation mechanism of weddellite nanocrystals studied by X-ray diffraction and infrared spectroscopy. Phys Chem Chem Phys 12:14560–14566
Elliott JC (1994) Structure and chemistry of the apatites and other calcium orthophosphates. Elsevier, Amsterdam
Elliott JC (2002) Calcium phosphate biominerals. Rev Min Geochem 48:427–453
Frank-Kamenetskaya OV (2008a) Structure, chemistry and synthesis of carbonate apatites—the main components of dental and bone tissues. In: Krivovichev SV (ed) Minerals as advanced materials I. Springer, Berlin
Frank-Kamenetskaya OV (2008b) Crystal chemistry and synthesis of carbonate apatites—main minerals in living organisms. In: Proceeding of the 9th international congress for applied mineralogy. Brisbane, Australia
Frank-Kamenetskaya OV, Golubtsov VV, Pikhur OL, Zorina ML, Plotkina YuV (2004) Nonstoichiometric apatite of the human dental hard tissues (the age alterations). Proc All-Rus Miner Soc 5:120–130 (in Russian)
Frank-Kamenetskaya O, Kol’tsov A, Kuz’mina M, Zorina M, Poritskaya L (2011) Ion substitutions and non-stoichiometry of carbonated apatite-(CaOH) synthesised by precipitation and hydrothermal methods. J Mol Struct 992: 9–18
Gross KA, Berndt CC (2002) Biomedical applications of apatites. Rev Min Geochem 48:631–672
Handschin RG, Stern WB (1992) Crystallographic lattice refinement of human bone. Calcified Tissue Int 51:111–120
Izatulina AR, Yelnikov VYu (2008) Structure, chemistry and crystallization conditions of calcium oxalates—the main components of kidney stones. In: Krivovichev SV (ed) Minerals as advanced materials I. Springer, Berlin
Izatulina AR, Guzhiy VV, Frank-Kamenetskaya OV (2014) Weddellite from renal stones: Structure refinement and dependence of crystal chemical features on H2O content. Am Mineral 99:2–7
Kalyuzhniy VP (2003) Electrolytes in health and disease and methods of their study. Terra medica 1:13–18 (in Russian)
Korago AA (1992) Introduction to biomineralogy. Nedra, St. Petersburg (in Russian)
Kuz’mina MA, Zhuravlev SV, El’nikov V.Yu. Frank Kamenetskaya OV (2009) The effect of impurities on crystallization and morphology of struvite (mineral of kidney stones) in the experiment condition. Proc All-Rus Miner Soc 6: 89–95 (in Russian)
Kuz’mina MA, Zhuravlev SV, Frank Kamenetskaya OV (2013) The effect of medium chemistry on the solubility and morphology of brushite crystals. Geol Ore Deposits 8:1–6
Meneghini C, Dalconi MC, Nuzzo S, Mobilio S, Wenk RH (2003) Rietveld refinement on X-ray diffraction patterns of bioapatite in human fetal bones. Biophys J 84:2021–2029
Pikhur OL, Rosseeva EV, Plotkina YuV, Kasbohm J, Golovanova OA, Frank-Kamenetskaya OV, Zorina ML (2008) Features of the morphology and composition of salivary calculi of patients from Saint-Petersburg region. Med Geol Newslett 12:24–29
Rosseeva EV, Frank-Kamenetskaya OV, Golovanova OA, Zorina ML (2009) Simulation of mineral phase formation from human oral-like fluids. Vestnik SPbGU Ser 7(2):12–21
Rosseeva EV, Nikolaev AM, Morozov MV, Frank-Kamenetskaya OV, Lamanova LM (2012) Bioapatites of calcificates of mitral valves. http://www.minsoc.ru/2012–1-111-0 (in Russian)
Rusakov AV, Frank-Kamenetskaya OV, Gurzhiy VV, Zelenskaya MS, Izatulina AR, Sazanova KV (2014) Refinement of the crystal structures of biomimetic weddellites produced by microscopic fungus Aspergillus niger. Crystallogr Rep 59:362–368
Severin ES (ed) (2003) Biochemistry. GEOTAR Med, Moscow (in Russian)
Shannon RD (1976) Revised effective ionic radii and systematic studies of interatomic distances in halides and chaleogenides. Acta Crystallogr A 32:751–767
Sheldrick GM (2004) SADABS. University of Göttingen, Germany
Sheldrick GM (2008) A short history of SHELX. Acta Crystallogr A 64:112–122
Tazzoli V, Domeneghetti C (1980) The crystal structures of whewellite and weddellite: re-examination and comparison. Am Mineral 65:327–334
Zhuravlev SV (2009) Synthesis and crystal chemical study of struvite and brushite (minerals of human kidney stones). Master’s thesis, Saint Petersburg State University (in Russian)
Acknowledgments
XRD studies had been performed at the X-ray Diffraction Centre of St.Petersburg State University. The work was supported by Saint Petersburg University (project 3.38.243.2015) and RFBR (projects 11-05-90425-Ukr_f _a, 13-05-90432 Ukr_f _a).
The authors are very grateful to V. Yu. El’nikov, E.V. Rosseeva, I.V. Rozhdestvenskaya and S.V. Zhuravlev for active collaboration in this work. They would like also to thank Yu. L. Kretser and M.P. Pavlov for electron probe microanalyses conduction and to S.N. Zimina for gas-volumetric method measurements.
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Frank-Kamenetskaya, O.V., Izatulina, A.R., Kuz’mina, M.A. (2016). Ion Substitutions, Non-stoichiometry, and Formation Conditions of Oxalate and Phosphate Minerals of the Human Body. In: Frank-Kamenetskaya, O., Panova, E., Vlasov, D. (eds) Biogenic—Abiogenic Interactions in Natural and Anthropogenic Systems. Lecture Notes in Earth System Sciences. Springer, Cham. https://doi.org/10.1007/978-3-319-24987-2_33
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