Overview
- Editors:
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Daniel L. Kaplan
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Florida State Univ. College of Medi, TALLAHASSEE, USA
- Focus on replication initiation, a complex and highly regulated step of replication
- Concentrate on eukaryotes, with relevance to humans and disease
- Reveal in detail the molecular mechanisms of initiation, including protein function and regulation
- Includes supplementary material: sn.pub/extras
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Table of contents (26 chapters)
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- Nalini Dhingra, Daniel L. Kaplan
Pages 1-21
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- Kyle N. Klein, David M. Gilbert
Pages 39-63
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- Mónica P. Gutiérrez, David M. MacAlpine
Pages 87-104
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- M. K. Raghuraman, Ivan Liachko
Pages 123-141
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- Naoko Yoshizawa-Sugata, Satoshi Yamazaki, Hisao Masai
Pages 143-158
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- Timothy Hoggard, Catherine A. Fox
Pages 159-188
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- Alberto Riera, Christian Speck
Pages 189-211
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- Johanna Paik, Serena Giovinazzi, Akash Gunjan
Pages 213-237
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- Seiji Tanaka, Hiroyuki Araki
Pages 263-278
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- Daniel Rossbach, Robert A. Sclafani
Pages 279-296
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- Karl-Uwe Reußwig, Dominik Boos, Boris Pfander
Pages 297-318
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- Ryan M. Baxley, Yee Mon Thu, Anja-Katrin Bielinsky
Pages 319-341
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- Giacomo De Piccoli, Agnieszka Gambus
Pages 343-370
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- Helmut Pospiech, Anna Szambowska
Pages 393-409
About this book
​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings.Â
The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA.  It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.
Editors and Affiliations
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Florida State Univ. College of Medi, TALLAHASSEE, USA
Daniel L. Kaplan
About the editor
Daniel Kaplan, PhD is an Associate Professor in the Department of Biomedical Sciences at Florida State University College of Medicine. He is the director of the Kaplan Lab that studies DNA replication and genome maintenance. Dr. Kaplan is also the Assistant Course Director for the Medical Microbiology course.
Daniel Kaplan has been studying microbiology, biochemistry, and genetics for over 20 years. As an assistant professor at Vanderbilt University, Dr. Kaplan led a team that published primary research articles that investigated how DNA replication is initiated in budding yeast. As a post-doctoral fellow, Daniel Kaplan worked with National Academy of Science member Mike O’Donnell at Rockefeller University and published manuscripts on the function and mechanism of bacterial and yeast replication fork helicases. In graduate school, Daniel Kaplan worked with Nobel Laureate Thomas Steitz at Yale University to determine how the bacterial replication fork helicase, DnaB, modulates DNA structure. Dr. Kaplan attended Yale Medical School and received training in cancer research before entering graduate school.
