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Light/Heavy Chain Deposition Disease as a Systemic Disorder

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Amyloid and Related Disorders

Part of the book series: Current Clinical Pathology ((CCPATH))

Abstract

Light/heavy chain deposition disease (LHCDD) is a disorder with predominantly renal manifestations, though sometimes associated with systemic involvement. While the recognition of LHCDD in the kidney by pathologists has increased considerably in the last decade, that is not the case when other organs are involved. If the patient has already a diagnosis of LCHDD, then the index of suspicion is raised and recognition of extrarenal manifestations is markedly improved. This chapter highlights diagnostic criteria, challenges, and pitfalls in the differential diagnosis of LHCDD in non-renal sites. It also discusses pathogenic mechanisms associated with organ pathology.

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Author information

Authors and Affiliations

  1. Department of Pathology, Louisiana State University Health Sciences Center, 1501 Kings Highway, 71103, Shreveport, LA, USA

    Guillermo A. Herrera MD

  2. Departments of Pathology and Medicine, Louisiana State University, Shreveport, LA, USA

    Elba A. Turbat-Herrera MD

Authors
  1. Guillermo A. Herrera MD
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  2. Elba A. Turbat-Herrera MD
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Corresponding author

Correspondence to Guillermo A. Herrera MD .

Editor information

Editors and Affiliations

  1. Department of Pathology, Loyola University Medical Center, Maywood, Illinois, USA

    Maria M. Picken

  2. Department of Pathology, LSU Health Shreveport, Shreveport, Louisiana, USA

    Guillermo A. Herrera

  3. Department of Pathology and Laboratory Medicine, Department of Pathology and Laboratory Medicine, New York, New York, USA

    Ahmet Dogan

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Herrera, G.A., Turbat-Herrera, E.A. (2015). Light/Heavy Chain Deposition Disease as a Systemic Disorder. In: Picken, M., Herrera, G., Dogan, A. (eds) Amyloid and Related Disorders. Current Clinical Pathology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-19294-9_10

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  • DOI: https://doi.org/10.1007/978-3-319-19294-9_10

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-19293-2

  • Online ISBN: 978-3-319-19294-9

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