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Insights into Heart Development and Regeneration

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Introduction to Translational Cardiovascular Research

Abstract

The heart is one of the first organs to form and function during the development of an organism. Cardiac development, morphology and transcriptional networks involved in cardiac patterning, across species, are reviewed. These genes are most commonly mutated in Congenital Heart Disease. In parallel, recent advances in understanding how the cardiac development program is recapitulated during cardiac regeneration are also presented. We discuss models of cardiac regeneration in zebrafish and newborn mice and how these could be utilized in the context of translational research.

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Notes

  1. 1.

    Smads are cytoplasm-signaling proteins which regulate gene transcription in response to BMP and its receptors of the TGF-β superfamily.

  2. 2.

    Differences in nomenclature rules between species are indicated in the way orthologue genes and proteins are written: for example GATA4 refers to the human gene, Gata4 to the mouse and gata4 to the zebrafish orthologue. When referring to proteins GATA4 refers to the human or mouse while Gata4 to the zebrafish one.

  3. 3.

    Wnt canonical signaling refers to the signaling mediated by the β-catenin.

Abbreviations

ANF:

Atrial natriuretic factor

AVC:

Atrioventricular canal

BMP:

Bone morphogenetic protein

CMC:

Cardiomyocytes

ECM:

Extracellular cell matrix

EMT:

Epithelial to mesenchymal transition

Eomes:

Eomesodermin

FGF:

Fibroblast growth factor

FHF:

First heart field

FUCCI:

Fluorescent ubiquitination-based cell cycle indicator

NGF:

Nerve growth factor

OFT:

Outflow tract

PDGF:

Platelet-derived growth factor

REG:

Regeneration

SHF:

Second heart field

SRF:

Serum response factor

TGF-β:

Transforming growth factor beta

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Authors and Affiliations

  1. Developmental Biology, Biomedical Research Foundation, Academy of Athens, Athens, Greece

    Dimitris Beis, Stamatia Kalogirou & Nikolaos Tsigkas

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  1. Dimitris Beis
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  2. Stamatia Kalogirou
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  3. Nikolaos Tsigkas
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Correspondence to Dimitris Beis .

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Editors and Affiliations

  1. Academy of Athens, Biomedical Research Foundation, Athens, Greece

    Dennis V. Cokkinos

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© 2015 Springer International Publishing Switzerland

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Beis, D., Kalogirou, S., Tsigkas, N. (2015). Insights into Heart Development and Regeneration. In: Cokkinos, D. (eds) Introduction to Translational Cardiovascular Research. Springer, Cham. https://doi.org/10.1007/978-3-319-08798-6_2

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  • DOI: https://doi.org/10.1007/978-3-319-08798-6_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-08797-9

  • Online ISBN: 978-3-319-08798-6

  • eBook Packages: MedicineMedicine (R0)

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