Abstract
The chemical modification of biomaterials (i.e., polyesters, polysaccharides) can offer the opportunity to develop multifunctional platforms characterized by a combination of suitable properties and useful for biomedical applications. Polydopamine (PDA) is a mussel-inspired polymer with excellent properties such as adsorption ability, high hydrophilicity, electrical properties and numerous functional groups for immobilizing biomolecules. Due to high adhesion properties to almost all kinds of substrates PDA it has been largely used as coating for surface modification of material to modulate cellular responses, including cell spreading, migration, proliferation, and differentiation. In order to develop bio-functionalized systems, PDA was proposed as coating of biomaterials differently processed in form of sub-micrometric fibres, microgels and foams. Starting by a dopamine precursor solution, PDA coating deposition on substrates was performed by exploring different methodologies. In particular, poly-ε-caprolactone (PCL) electrospun fibres coated with PDA by electrofluidodynamic process was reported as possible bio-conductive interfaces. Preliminary results, in terms of synthesis conditions, structural characterization, and in vitro cell studies suggested that polymerization/oxidation reactions can be properly optimized to guide PDA self-assembly in order to control surface properties, and ultimately, influence cell materials interactions.
Iriczalli Cruz-Maya: Equal contribution.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Jo YK, Kim HJ, Jeong Y, Joo KI, Cha HJ (2018) Biomimetic surface engineering of biomaterials by using recombinant mussel adhesive proteins. Adv Mater Interfaces 5:180006. https://doi.org/10.1002/admi.201800068
Perikamana SKM, Lee J, Lee YB, Shin YM, Lee EJ, Mikos AG, Shin H (2015) Materials from mussel-inspired chemistry for cell and tissue engineering applications. Biomacromolecules 16(9):2541–2555. https://doi.org/10.1021/acs.biomac.5b00852
Neto AI, Cibrão AC, Correia CR, Carvalho R, Luz GM, Ferrer GG, Botelho G, Picart C, Alves NM, Mano JF (2014) Nanostructured polymeric coatings based on chitosan and dopamine-modified hyaluronic acid for biomedical applications. Small 10(12):2459–2469. https://doi.org/10.1002/smll.201303568
Liebscher J (2019) Chemistry of polydopamine—scope, variation, and limitation. Eur J Org Chem 4976–4994. https://doi.org/10.1002/ejoc.201900445
Dreyer DR, Miller DJ, Freeman BD, Paul DR, Bielawski CW (2012) Elucidating the structure of poly(dopamine). Langmuir 28:6428–6435. https://doi.org/10.1021/la204831b
Cheng W, Zeng X, Chen H, Li Z, Zeng W, Mei L, Zhao Y (2019) Versatile polydopamine platforms: synthesis and promising applications for surface modification and advanced nanomedicine. ACS Nano 13:8537–8565. https://doi.org/10.1021/acsnano.9b04436
Lynge ME, van der Westen R, Postma A, Städler B (2011) Polydopamine—a nature-inspired polymer coating for biomedical science. Nanoscale 3:4916–4128. https://doi.org/10.1039/c1nr10969c
Lee H, Dellatore SM, Miller WM, Messersmith PB (2007) Mussel-inspired surface chemistry for multifunctional coatings. Science 318(5849):426–430. https://doi.org/10.1126/science.1147241
Zuppolini S, Cruz-Maya I, Guarino V, Borriello A (2020) Optimization of polydopamine coatings onto poly-ε-caprolactone electrospun fibres for the fabrication of bio-electroconductive interfaces. J Funct Biomater 11:19. https://doi.org/10.3390/jfb11010019
Wang H, Lin C, Zhang X, Lin K, Wang X, Shen SG (2019) Mussel-inspired polydopamine coating: a general strategy to enhance osteogenic differentiation and osseointegration for diverse implants. ACS Appl Mater Interfaces 11:7615–7625. https://doi.org/10.1021/acsami.8b21558
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Switzerland AG
About this paper
Cite this paper
Zuppolini, S., Cruz-Maya, I., Guarino, V., Venditto, V., Borriello, A. (2021). Design of Biofunctional Platforms: Differently Processed Biomaterials with Polydopamine Coating. In: Di Francia, G., Di Natale, C. (eds) Sensors and Microsystems. AISEM 2020. Lecture Notes in Electrical Engineering, vol 753. Springer, Cham. https://doi.org/10.1007/978-3-030-69551-4_3
Download citation
DOI: https://doi.org/10.1007/978-3-030-69551-4_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-69550-7
Online ISBN: 978-3-030-69551-4
eBook Packages: EngineeringEngineering (R0)