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High-Speed Electron Microscopy

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Springer Handbook of Microscopy

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Abstract

High-speed electron microscopy has emerged as a well-established in situ transmission electron microscopy ( ) capability that can provide observations and measurements of complex, transient materials phenomena with high spatial and temporal resolutions. The development and advancement of the two categories of high-speed electron microscopy, each optimized for specific regimes of spatial and temporal resolutions—single-shot dynamic TEM ( ) and stroboscopic or ultrafast TEM ( )—are reviewed and the technologies employed in both techniques are described. Limitations of the techniques are described and example applications are provided. Finally, an outlook for future development of time-resolved electron microscopy is provided, offering potential directions for new levels of performance and flexibility.

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References

  • P.B. Hirsch: Direct observations of dislocations by transmission electron microscopy: Recollections of the period 1946–56, Proc. Royal Soc. A 371, 160 (1980)

    Google Scholar 

  • P.B. Hirsch: Direct observations of moving dislocations: Reflections on the thirtieth anniversary of the first recorded observations of moving dislocations by transmission electron microscopy, Mater. Sci. Eng. 84, 1 (1986)

    Google Scholar 

  • P.B. Hirsch, R.W. Horne, M.J. Whelan: Direct observations of the arrangement and motion of dislocations in aluminium, Philos. Mag. 1, 677 (1956)

    CAS  Google Scholar 

  • G. Mourou, S. Williamson: Picosecond electron-diffraction, Appl. Phys. Lett. 41, 44 (1982)

    CAS  Google Scholar 

  • S. Williamson, G. Mourou: Electron-diffraction in the picosecond domain, Appl. Phys. B 28, 249 (1982)

    Google Scholar 

  • S. Williamson, G. Mourou, J.C.M. Li: Time-resolved laser-induced phase-transformation in aluminum, Phys. Rev. Lett. 52, 2364 (1984)

    CAS  Google Scholar 

  • H.E. Elsayed-Ali, J.W. Herman: Picosecond time-resolved surface-lattice temperature probe, Appl. Phys. Lett. 57, 1508 (1990)

    CAS  Google Scholar 

  • R.C. Dudek, P.M. Weber: Ultrafast diffraction imaging of the electrocyclic ring-opening reaction of 1,3-cyclohexadiene, J. Phys. Chem. A 105, 4167 (2001)

    CAS  Google Scholar 

  • C.Y. Ruan, F. Vigliotti, V.A. Lobastov, S.Y. Chen, A.H. Zewail: Ultrafast electron crystallography: Transient structures of molecules, surfaces, and phase transitions, Proc. Natl. Acad. Sci. USA 101, 1123 (2004)

    CAS  Google Scholar 

  • C.Y. Ruan, V.A. Lobastov, F. Vigliotti, S.Y. Chen, A.H. Zewail: Ultrafast electron crystallography of interfacial water, Science 304, 80 (2004)

    CAS  Google Scholar 

  • B.J. Siwick, J.R. Dwyer, J.E. Jordan, R.J.D. Miller: Femtosecond electron diffraction studies of strongly driven structural phase transitions, Chem. Phys. 299, 285 (2004)

    CAS  Google Scholar 

  • Gatan Inc.: www.gatan.com/products/tem-imaging-spectroscopy (2017)

  • P. Emma, R. Akre, J. Arthur, R. Bionta, C. Bostedt, J. Bozek, A. Brachmann, P. Bucksbaum, R. Coffee, F.-J. Decker, Y. Ding, D. Dowell, S. Edstrom, A. Fisher, J. Frisch, S. Gilevich, J. Hastings, G. Hays, P. Hering, Z. Huang, R. Iverson, H. Loos, M. Messerschmidt, A. Miahnahri, S. Moeller, H.-D. Nuhn, G. Pile, D. Ratner, J. Rzepiela, D. Schultz, T. Smith, P. Stefan, H. Tompkins, J. Turner, J. Welch, W. White, J. Wu, G. Yocky, J. Galayda: First lasing of an ångstrom-wavelength free-electron laser, Nat. Photonics 4, 641 (2010)

    CAS  Google Scholar 

  • T. Ishikawa, H. Aoyagi, T. Asaka, Y. Asano, N. Azumi, T. Bizen, H. Ego, K. Fukami, T. Fukui, Y. Furukawa, S. Goto, H. Hanaki, T. Hara, T. Hasegawa, T. Hatsui, A. Higashiya, T. Hirono, N. Hosoda, M. Ishii, T. Inagaki, Y. Inubushi, T. Itoga, Y. Joti, M. Kago, T. Kameshima, H. Kimura, Y. Kirihara, A. Kiyomichi, T. Kobayashi, C. Kondo, T. Kudo, H. Maesaka, X.M. Maréchal, T. Masuda, S. Matsubara, T. Matsumoto, T. Matsushita, S. Matsui, M. Nagasono, N. Nariyama, H. Ohashi, T. Ohata, T. Ohshima, S. Ono, Y. Otake, C. Saji, T. Sakurai, T. Sato, K. Sawada, T. Seike, K. Shirasawa, T. Sugimoto, S. Suzuki, S. Takahashi, K. Takebe, A. Tokuhisa, H. Tomizawa, K. Tono, S. Wu, M. Yabashi, M. Yamaga, A. Yamashita, K. Yanagida, C. Zhang, T. Shintake, H. Kitamura, N. Kumagai: A compact x-ray free-electron laser emitting in the sub-ångstrom region, Nat. Photonics 6, 540 (2010)

    Google Scholar 

  • S.P. Weathersby, G. Brown, M. Centurion, T.F. Chase, R. Coffee, J. Corbett, J.P. Eichner, J.C. Frisch, A.R. Fry, M. Gühr, N. Hartmann, C. Hast, R. Hettel, R.K. Jobe, E.N. Jongewaard, J.R. Lewandowski, R.K. Li, A.M. Lindenberg, I. Makasyuk, J.E. May, D. McCormick, M.N. Nguyen, A.H. Reid, X. Shen, K. Sokolowski-Tinten, T. Vecchione, S.L. Vetter, J. Wu, J. Yang, H.A. Dürr, X.J. Wang: Mega-electron-volt ultrafast electron diffraction at SLAC National Accelerator Laboratory, Rev. Sci. Instrum. 86, 073702 (2015)

    CAS  Google Scholar 

  • V.A. Lobastov, R. Srinivasan, A.H. Zewail: Four-dimensional ultrafast electron microscopy, Proc. Natl. Acad. Sci. USA 102, 7069 (2005)

    CAS  Google Scholar 

  • A.H. Zewail: 4D ultrafast electron diffraction, crystallography, and microscopy, Annu. Rev. Phys. Chem. 57, 65 (2006)

    CAS  Google Scholar 

  • B. Barwick, H.S. Park, O.H. Kwon, J.S. Baskin, A.H. Zewail: 4D imaging of transient structures and morphologies in ultrafast electron microscopy, Science 322, 1227 (2008)

    CAS  Google Scholar 

  • A.H. Zewail: Four-dimensional electron microscopy, Science 328, 187 (2010)

    CAS  Google Scholar 

  • A.H. Zewail, J.M. Thomas: 4D Electron Microscopy (Imperial College Press, London 2010)

    Google Scholar 

  • T. LaGrange, M.R. Armstrong, K. Boyden, C.G. Brown, G.H. Campbell, J.D. Colvin, W.J. DeHope, A.M. Frank, D.J. Gibson, F.V. Hartemann, J.S. Kim, W.E. King, B.J. Pyke, B.W. Reed, M.D. Shirk, R.M. Shuttlesworth, B.C. Stuart, B.R. Torralva, N.D. Browning: Single-shot dynamic transmission electron microscopy, Appl. Phys. Lett. 89, 044105 (2006)

    Google Scholar 

  • M.R. Armstrong, K. Boyden, N.D. Browning, G.H. Campbell, J.D. Colvin, W.J. DeHope, A.M. Frank, D.J. Gibson, F. Hartemann, J.S. Kim, W.E. King, T.B. LaGrange, B.J. Pyke, B.W. Reed, R.M. Shuttlesworth, B.C. Stuart, B.R. Torralva: Practical considerations for high spatial and temporal resolution dynamic transmission electron microscopy, Ultramicroscopy 107, 356 (2007)

    CAS  Google Scholar 

  • M.R. Armstrong, B.W. Reed, B.R. Torralva, N.D. Browning: Prospects for electron imaging with ultrafast time resolution, Appl. Phys. Lett. 90, 114101 (2007)

    Google Scholar 

  • T. LaGrange, G.H. Campbell, B. Reed, M. Taheri, J.B. Pesavento, J.S. Kim, N.D. Browning: Nanosecond time-resolved investigations using the in situ of dynamic transmission electron microscope (DTEM), Ultramicroscopy 108, 1441 (2008)

    CAS  Google Scholar 

  • B. Reed, M.R. Armstrong, N.D. Browning, G.H. Campbell, J.E. Evans, T. LaGrange, D.J. Masiel: The evolution of ultrafast electron microscope instrumentation, Microsc. Microanal. 15, 272 (2009)

    CAS  Google Scholar 

  • G.H. Campbell, T. LaGrange, J.S. Kim, B.W. Reed, N.D. Browning: Quantifying transient states in materials with the dynamic transmission electron microscope, J. Electron Microsc. 59, S67 (2010)

    CAS  Google Scholar 

  • B.W. Reed, T. LaGrange, R.M. Shuttlesworth, D.J. Gibson, G.H. Campbell, N.D. Browning: Solving the accelerator-condenser coupling problem in a nanosecond dynamic transmission electron microscope, Rev. Sci. Instrum. 81, 053706 (2010)

    CAS  Google Scholar 

  • T. LaGrange, B.W. Reed, M.K. Santala, J.T. McKeown, A. Kulovits, J.M. Wiezorek, L. Nikolova, F. Rosei, B.J. Siwick, G.H. Campbell: Approaches for ultrafast imaging of transient material processes in the transmission electron microscope, Micron 43, 1108 (2012)

    CAS  Google Scholar 

  • G.H. Campbell, J.T. McKeown, M.K. Santala: Time resolved electron microscopy for in situ experiments, Appl. Phys. Rev. 1, 041101 (2014)

    Google Scholar 

  • T. LaGrange, B.W. Reed, D.J. Masiel: Movie-mode dynamic electron microscopy, MRS Bulletin 40, 22 (2015)

    CAS  Google Scholar 

  • T. LaGrange, G.H. Campbell, J.D. Colvin, B. Reed, W.E. King: Nanosecond time resolved electron diffraction studies of the \(\upalpha\rightarrow\upbeta\) transition in pure Ti thin films using the dynamic transmission electron microscope (DTEM), J. Mater. Sci. 41, 4440 (2006)

    CAS  Google Scholar 

  • J.S. Kim, T. LaGrange, B.W. Reed, M.L. Taheri, M.R. Armstrong, W.E. King, N.D. Browning, G.H. Campbell: Imaging of transient structures using nanosecond in situ TEM, Science 321, 1472 (2008)

    CAS  Google Scholar 

  • M.K. Santala, B.W. Reed, S. Raoux, T. Topuria, T. LaGrange, G.H. Campbell: Irreversible reactions studied with nanosecond TEM movies: Laser crystallization of phase change materials, Appl. Phys. Lett. 102, 174105 (2013)

    Google Scholar 

  • J.T. McKeown, Y. Wu, J.D. Fowlkes, P.D. Rack, G.H. Campbell: Simultaneous in-situ synthesis and characterization of Co@Cu core-shell nanoparticle arrays, Adv. Mater. 27, 1060 (2014)

    Google Scholar 

  • J.T. McKeown, A. Kulovits, C. Liu, K. Zweiacker, B.W. Reed, T. LaGrange, J.M.K. Wiezorek, G.H. Campbell: In situ transmission electron microscopy of crystal growth-mode transitions during rapid solidification of a hypoeutectic Al-Cu alloy, Acta Mater. 65, 56 (2014)

    CAS  Google Scholar 

  • B.W. Reed, F.R. Chung, M.J. Wang, T. LaGrange, K.J. Koski: Temperature-driven disorder-order transitions in 2D copper-intercalated MoO\({}_{3}\) revealed using dynamic transmission electron microscopy, 2D Materials 1, 035001 (2014)

    Google Scholar 

  • M.K. Santala, S. Raoux, G.H. Campbell: Kinetics of liquid-mediated crystallization of amorphous Ge from multi-frame dynamic TEM, Appl. Phys. Lett. 107, 252106 (2015)

    Google Scholar 

  • J.T. McKeown, K. Zweiacker, C. Liu, D.R. Coughlin, A.J. Clarke, J.K. Baldwin, J.W. Gibbs, J.D. Roehling, S.D. Imhoff, P.J. Gibbs, D. Tourret, J.M.K. Wiezorek, G.H. Campbell: Time-resolved in situ measurements during rapid alloy solidification: Experimental insight for additive manufacturing, JOM 68, 985 (2016)

    CAS  Google Scholar 

  • O. Bostanjoglo, R. Elschner, Z. Mao, T. Nink, M. Weingartner: Nanosecond electron microscopes, Ultramicroscopy 81, 141 (2000)

    CAS  Google Scholar 

  • O. Bostanjoglo: High-speed electron microscopy, Adv. Imaging Electron Phys. 121, 1 (2002)

    CAS  Google Scholar 

  • H. Dömer, O. Bostanjoglo: High-speed transmission electron microscope, Rev. Sci. Instrum. 74, 4369 (2003)

    Google Scholar 

  • C.D. Child: Discharge from hot CaO, Phys. Rev. 32, 492 (1911)

    CAS  Google Scholar 

  • O. Bostanjoglo, T. Rosin: Stroboscopic study on ultrasonic activity in electron-microscope, Mikroskopie 32, 190 (1976)

    Google Scholar 

  • A. Takaoka, K. Ura: Velocity measuring system for interface motion in TEM, J. Electron Microsc. 37, 117 (1988)

    CAS  Google Scholar 

  • H.S. Park, J.S. Baskin, O.-H. Kwon, A.H. Zewail: Atomic-scale imaging in real and energy space developed in ultrafast electron microscopy, Nano Lett. 7, 2545 (2007)

    CAS  Google Scholar 

  • G.V. Spivak, O.P. Pavlyuchenko, V.I. Petrov: Electron microscopic observation of alterations of the domain structure of magnetic films, Bull. Acad. Sci. USSR Phys. Ser. 30, 822 (1966)

    Google Scholar 

  • O. Bostanjoglo, T. Rosin: Stroboscopic TEM studies of high-frequency magnetic test materials, Mikroskopie 36, 344 (1980)

    Google Scholar 

  • O.-H. Kwon, B. Barwick, H.S. Park, J.S. Baskin, A.H. Zewail: Nanoscale mechanical drumming visualized by 4D electron microscopy, Nano Lett. 8, 3557 (2008)

    CAS  Google Scholar 

  • D.J. Flannigan, P.C. Samartzis, A. Yurtsever, A.H. Zewail: Nanomechanical motions of cantilevers: Direct imaging in real space and time with 4D electron microscopy, Nano Lett. 9, 875 (2009)

    CAS  Google Scholar 

  • F. Carbone, B. Barwick, O.H. Kwon, H.S. Park, J.S. Baskin, A.H. Zewail: EELS femtosecond resolved in 4D ultrafast electron microscopy, Chem. Phys. Lett. 468, 107 (2009)

    CAS  Google Scholar 

  • B.-L. Qian, H.E. Elsayed-Ali: Electron pulse broadening due to space charge effects in a photoelectron gun for electron diffraction and streak camera systems, J. Appl. Phys. 91, 462 (2002)

    CAS  Google Scholar 

  • D.J. Bradley, A.G. Roddie, W. Sibbett, M.H. Key, M.J. Lamb, C.L.S. Lewis, P. Sachsenmaier: Picosecond x-ray chronoscopy, Opt. Commun. 15, 231–236 (1975)

    Google Scholar 

  • Z. Chang, A. Rundquist, J. Zhou, M.M. Murnane, H.C. Kapteyn, X. Liu, B. Shan, J. Liu, L. Niu, M. Gong, X. Zhang: Demonstration of a sub-picosecond x-ray streak camera, Appl. Phys. Lett. 69, 133 (1996)

    CAS  Google Scholar 

  • R.K. Li, P. Musumeci: Single-shot MeV transmission electron microscopy with picosecond temporal resolution, Phys. Rev. Appl. 2, 024003 (2014)

    Google Scholar 

  • D. Xiang, F. Fu, J. Zhang, X. Huang, L. Wang, X. Wang, W. Wan: Accelerator-based single-shot ultrafast transmission electron microscope with picosecond temporal resolution and nanometer spatial resolution, Nucl. Instrum. Methods Phys. Res. A 759, 74 (2014)

    CAS  Google Scholar 

  • S. Hihath, M.K. Santala, K. van Benthem: High-speed nanoscale characterization of dewetting via dynamic transmission electron microscopy, J. Appl. Phys. 120, 085301 (2016)

    Google Scholar 

  • R.K. Reich, D.D. Rathman, D.M. O'Mara, D.J. Young, A.H. Loomis, E.J. Kohler, R.M. Osgood, R.A. Murphy, M. Rose, R. Berger, S.A. Watson, M.D. Ulibarri, T. Perry, B.B. Kosicki: High-speed, electronically shuttered solid-state imager technology, Rev. Sci. Instrum. 74, 2027 (2003)

    CAS  Google Scholar 

  • T.G. Etoh, D. Poggemann, G. Kreider, H. Mutoh, A.J.P. Theuwissen, A. Ruckelshausen, Y. Kondo, H. Maruno, K. Takubo, H. Soya, K. Takehara, T. Okinaka, Y. Takano: An image sensor which captures 100 consecutive frames at 1000000 frames/s, IEEE Trans. Electron Dev. 50, 144 (2003)

    Google Scholar 

  • H. Kleine, K. Hiraki, H. Maruyama, T. Hayashida, J. Yonai, K. Kitamura, Y. Kondo, T.G. Etoh: High-speed time-resolved color schlieren visualization of shock wave phenomena, Shock Waves 14, 333 (2005)

    Google Scholar 

  • M. El-Desouki, M.J. Deen, Q.Y. Fang, L. Liu, F. Tse, D. Armstrong: CMOS image sensors for high speed applications, Sensors 9, 430 (2009)

    Google Scholar 

  • Y. Tochigi, K. Hanzawa, Y. Kato, R. Kuroda, H. Mutoh, R. Hirose, H. Tominaga, K. Takubo, Y. Kondo, S. Sugawa: A global-shutter CMOS image sensor with readout speed of 1-Tpixel/s burst and 780-Mpixel/s continuous, IEEE J. Solid-State Circuits 48, 329 (2013)

    Google Scholar 

  • M.D. Grapes, T. LaGrange, L.H. Friedman, B.W. Reed, G.H. Campbell, T.P. Weihs, D.A. LaVan: Combining nanocalorimetry and dynamic transmission electron microscopy for in situ characterization of materials processes under rapid heating and cooling, Rev. Sci. Instrum. 85, 084902 (2014)

    Google Scholar 

  • M.D. Grapes, Y. Zhang, M.K. Santala, T. Voisin, G.H. Campbell, T.P. Weihs: In situ high-rate mechanical testing in the dynamic transmission electron microscope. In: MEMS and Nanotechnology, onference Proceedings of the Society for Experimental Mechanics Series, Vol. 5, ed. by B. Prorok, L. Starman (Springer, Cham 2016)

    Google Scholar 

  • T. Voisin, M.D. Grapes, Y. Zhang, N.J. Lorenzo, J.P. Ligda, B.E. Schuster, M.K. Santala, T. Li, G.H. Campbell, T.P. Weihs: DTEM in situ mechanical testing: Defect motion at high strain rates. In: Dynamic Behavior of Materials, Proceedings of the 2016 Annual Conference on Experimental and Applied Mechanics, Vol. 1, ed. by D. Casem, L. Lamberson, J. Kimberley (Springer, Cham 2016)

    Google Scholar 

  • W.E. King, G.H. Campbell, A. Frank, B. Reed, J.F. Schmerge, B.J. Siwick, B.C. Stuart, P.M. Weber: Ultrafast electron microscopy in materials science, biology, and chemistry, J. Appl. Phys. 97, 111101 (2005)

    Google Scholar 

  • H. Rose, R. Spehr: Energy broadening in high-density electron and ion-beams: The Boersch effect. In: Applied Charged Particle Optics, Adv. Electron. Electron Phys. Suppl. 13C, ed. by A. Septier (1983) p. 475

    Google Scholar 

  • G.H. Jansen: Coulomb Interactions in Particle Beams (Academic Press, San Diego 1990)

    Google Scholar 

  • P. Kruit, G.H. Jansen: Space charge and statistical Coulomb effects. In: Handbook of Charged Particle Optics, ed. by J. Orloff (CRC, Boca Raton 1997) p. 275

    Google Scholar 

  • O. Bostanjoglo, F. Heinricht, F. Wunsch: Performance of a laser-pulsed thermal electron gun. In: Proc. 12th Int. Congr. Electron Microsc. (1990) p. 124

    Google Scholar 

  • K.H. Loeffler: Energy-spread generation in electron-optical instruments, Z. Angew. Phys. 27, 145 (1969)

    Google Scholar 

  • J.M. Cowley: Imaging. In: High-Resolution Transmission Electron Microscopy and Associated Techniques, ed. by P. Buseck, J.M. Cowley, L.E. Eyring (Oxford Univ. Press, Oxford 1992)

    Google Scholar 

  • A. Kulovits, J.M. Wiezorek, T. LaGrange, B.W. Reed, G.H. Campbell: Revealing the transient states of rapid solidification in aluminum thin films using ultrafast in situ transmission electron microscopy, Philos. Mag. Lett. 91, 287 (2011)

    CAS  Google Scholar 

  • K. Zweiacker, J.T. McKeown, C. Liu, T. LaGrange, B.W. Reed, G.H. Campbell, J.M. Wiezorek: Determination of crystal growth rates during rapid solidification of polycrystalline aluminum by nano-scale spatio-temporal in situ transmission electron microscopy, J. Appl. Phys. 120, 055106 (2016)

    Google Scholar 

  • M.M. Winseck, H.-Y. Cheng, G.H. Campbell, M.K. Santala: Crystallization kinetics of the phase change material GeSb\({}_{6}\)Te measured with dynamic transmission electron microscopy, Dalton Trans. 45, 9988 (2016)

    CAS  Google Scholar 

  • R.F. Egerton: Electron Energy Loss Spectroscopy in the Electron Microscope (Plenum, New York 1986)

    Google Scholar 

  • R. Henderson: Realizing the potential of electron cryo-microscopy, Q. Rev. Biophys. 37, 3 (2004)

    CAS  Google Scholar 

  • R.F. Egerton: Control of radiation damage in the TEM, Ultramicroscopy 127, 100 (2013)

    CAS  Google Scholar 

  • R. Henderson: Cryoprotection of protein crystals against radiation-damage in electron and x-ray-diffraction, Proc. Royal Soc. B 241, 6–8 (1990)

    CAS  Google Scholar 

  • H.N. Chapman, P. Fromme, A. Barty, T.A. White, R.A. Kirian, A. Aquila, M.S. Hunter, J. Schulz, D.P. DePonte, U. Weierstall, R.B. Doak, F. Maia, A.V. Martin, I. Schlichting, L. Lomb, N. Coppola, R.L. Shoeman, S.W. Epp, R. Hartmann, D. Rolles, A. Rudenko, L. Foucar, N. Kimmel, G. Weidenspointner, P. Holl, M.N. Liang, M. Barthelmess, C. Caleman, S. Boutet, M.J. Bogan, J. Krzywinski, C. Bostedt, S. Bajt, L. Gumprecht, B. Rudek, B. Erk, C. Schmidt, A. Homke, C. Reich, D. Pietschner, L. Struder, G. Hauser, H. Gorke, J. Ullrich, S. Herrmann, G. Schaller, F. Schopper, H. Soltau, K.U. Kuhnel, M. Messerschmidt, J.D. Bozek, S.P. Hau-Riege, M. Frank, C.Y. Hampton, R.G. Sierra, D. Starodub, G.J. Williams, J. Hajdu, N. Timneanu, M.M. Seibert, J. Andreasson, A. Rocker, O. Jonsson, M. Svenda, S. Stern, K. Nass, R. Andritschke, C.D. Schroter, F. Krasniqi, M. Bott, K.E. Schmidt, X.Y. Wang, I. Grotjohann, J.M. Holton, T.R.M. Barends, R. Neutze, S. Marchesini, R. Fromme, S. Schorb, D. Rupp, M. Adolph, T. Gorkhover, I. Andersson, H. Hirsemann, G. Potdevin, H. Graafsma, B. Nilsson, J.C.H. Spence: Femtosecond x-ray protein nanocrystallography, Nature 470, 73 (2011)

    CAS  Google Scholar 

  • J.C.H. Spence: X-ray imaging: Ultrafast diffract-and-destroy movies, Nat. Photonics 2, 390 (2008)

    CAS  Google Scholar 

  • J. Tenboer, S. Basu, N. Zatsepin, K. Pande, D. Milathianaki, M. Frank, M. Hunter, S. Boutet, G.J. Williams, J.E. Koglin, D. Oberthuer, M. Heymann, C. Kupitz, C. Conrad, J. Coe, G.J. Roy-Chowdhury, U. Weierstall, D. James, D.J. Wang, T. Grant, A. Barty, O. Yefanov, J. Scales, C. Gati, C. Seuring, V. Srajer, R. Henning, P. Schwander, R. Fromme, A. Ourmazd, K. Moffat, J.J. Van Thor, J.C.H. Spence, P. Fromme, H.N. Chapman, M. Schmidt: Time-resolved serial crystallography captures high-resolution intermediates of photoactive yellow protein, Science 346, 1242 (2014)

    CAS  Google Scholar 

  • J.C.H. Spence: Outrunning damage: Electrons vs x-rays—timescales and mechanisms, Struct. Dyn. 4, 044027 (2017)

    Google Scholar 

  • J.C.H. Spence, G. Subramanian, P. Musumeci: Hollow cone illumination for fast TEM, and outrunning damage with electrons, J. Phys. B 48, 214003 (2015)

    Google Scholar 

  • S.P. Hau-Riege, R.A. London, H.N. Chapman: Pulse Requirements for Electron Diffraction Imaging of Single Biological Molecules, Lawrence Livermore National Laboratory Internal Report UCRL-TR-207533 (Lawrence Livermore National Lab. (LLNL), Livermore 2004)

    Google Scholar 

  • J.W. Lewellen: Overview of high-brightness electron guns. In: Proc. 22nd Int. Conf. LINAC (2004) pp. 842–846

    Google Scholar 

  • J.R. Fryer: The effect of dose-rate on imaging aromatic organic-crystals, Ultramicroscopy 23, 321 (1987)

    CAS  Google Scholar 

  • D.A. Plemmons, P.K. Suri, D.J. Flannigan: Probing structural and electronic dynamics with ultrafast electron microscopy, Chem. Mater. 27, 3178 (2015)

    CAS  Google Scholar 

  • A. Gahlmann, S.T. Park, A.H. Zewail: Ultrafast electron pulses for diffraction, crystallography and microscopy: Theoretical and experimental resolutions, Phys. Chem. Chem. Phys. 10, 2894 (2008)

    CAS  Google Scholar 

  • L. Piazza, T.T.A. Lummen, E. Quinonez, Y. Murooka, B.W. Reed, B. Barwick, F. Carbone: Simultaneous observation of the quantization and the interference pattern of a plasmonic near-field, Nat. Commun. 6, 6407 (2015)

    CAS  Google Scholar 

  • O. Bostanjoglo, H.P. Gemund: Low-temperature specimen holder for magnetization processes by means of short field pulse, Mikroskopie 34, 188 (1978)

    Google Scholar 

  • O. Bostanjoglo, T. Rosin: Resonance oscillations of magnetic domain-walls and Bloch lines observed by stroboscopic electron-microscopy, Phys. Status Solidi (a) 57, 561 (1980)

    CAS  Google Scholar 

  • O. Bostanjoglo, R. Liedtke: Tracing fast phase-transitions by electron-microscopy, Phys. Status Solidi (a) 60, 451 (1980)

    CAS  Google Scholar 

  • O. Bostanjoglo, G. Schlotzhauer: Impulse stimulated crystallization of Sb films investigated by time resolved TEM, Phys. Status Solidi (a) 68, 555 (1981)

    CAS  Google Scholar 

  • O. Bostanjoglo, G. Schlotzhauer, S. Schade: Shaping trigger pulses from noisy signals and time-resolved TEM of fast phase-transitions, Optik 61, 91 (1982)

    CAS  Google Scholar 

  • O. Bostanjoglo: Time-resolved TEM of pulsed crystallization of amorphous Si and Ge films, Phys. Status Solidi (a) 70, 473 (1982)

    CAS  Google Scholar 

  • O. Bostanjoglo, G. Hoffmann: Time-resolved TEM of transient effects in pulse annealing of Ge and Ge-Te films, Phys. Status Solidi (a) 73, 95 (1982)

    CAS  Google Scholar 

  • O. Bostanjoglo, W.R. Horinek: Pulsed TEM—A new method to detect transient structures in fast phase-transitions, Optik 65, 361 (1983)

    CAS  Google Scholar 

  • A.A. Ischenko, V.V. Golubkov, V.P. Spiridonov, A.V. Zgurskii, A.S. Akhmanov, M.G. Vabischevich, N. Bagratashvili: A stroboscopical gas-electron diffraction method for the investigation of short-lived molecular-species, Appl. Phys. B 32, 161 (1983)

    Google Scholar 

  • R.S. Becker, G.S. Higashi, J.A. Golovchenko: Low-energy electron-diffraction during pulsed laser annealing: A time-resolved surface structural study, Phys. Rev. Lett. 52, 307 (1984)

    CAS  Google Scholar 

  • A.P. Rood, J. Milledge: Combined flash-photolysis and gas-phase electron-diffraction studies of small molecules, J. Chem. Soc. Faraday Trans. 80, 1145 (1984)

    CAS  Google Scholar 

  • J.D. Ewbank, L. Schäfer, D.W. Paul, O.J. Benson, J.C. Lennox: Real-time data acquisition for gas electron-diffraction, Rev. Sci. Instrum. 55, 1598 (1984)

    CAS  Google Scholar 

  • O. Bostanjoglo, E. Endruschat, F. Heinricht, R.P. Tornow, W. Tornow: Short-interval electron-microscopy and pulsed lasers, Eur. J. Cell Biol. 44, 10 (1987)

    Google Scholar 

  • O. Bostanjoglo, J. Kornitzky, R.P. Tornow: Nanosecond double-frame electron-microscopy of fast phase-transitions, J. Phys. E 22, 1008 (1989)

    CAS  Google Scholar 

  • O. Bostanjoglo, R.P. Tornow, W. Tornow: Nanosecond-exposure electron-microscopy of laser-induced phase-transformations, Ultramicroscopy 21, 367 (1987)

    CAS  Google Scholar 

  • J.D. Ewbank, J.Y. Luo, J.T. English, R.F. Liu, W.L. Faust, L. Schafer: Time-resolved gas electron-diffraction study of the 193-nm photolysis of 1,2-dichloroethenes, J. Phys. Chem. 97, 8745 (1993)

    CAS  Google Scholar 

  • M. Dantus, S.B. Kim, J.C. Williamson, A.H. Zewail: Ultrafast electron-diffraction. 5. Experimental time resolution and applications, J. Phys. Chem. 98, 2782 (1994)

    CAS  Google Scholar 

  • H. Ihee, V.A. Lobastov, U.M. Gomez, B.M. Goodson, R. Srinivasan, C.Y. Ruan, A.H. Zewail: Direct imaging of transient molecular structures with ultrafast diffractions, Science 291, 458 (2001)

    CAS  Google Scholar 

  • J. Cao, Z. Hao, H.S. Park, C. Tao, D. Kau, L. Blaszczyk: Femtosecond electron diffraction for direct measurement of ultrafast atomic motions, Appl. Phys. Lett. 83, 1044 (2003)

    CAS  Google Scholar 

  • H. Dömer, O. Bostanjoglo: Phase explosion in laser-pulsed metal films, Appl. Surf. Sci. 208, 442 (2003)

    Google Scholar 

  • B.J. Siwick, J.R. Dwyer, J.E. Jordan, R.J.D. Miller: An atomic-level view of melting using femtosecond electron diffraction, Science 302, 1382 (2003)

    CAS  Google Scholar 

  • O. Bostanjoglo, T. Rosin: Stroboscopic Lorentz TEM at 100 kV up to 100 MHz. In: Proc. 7th Eur. Congr. Electron Microsc., ed. by P. Brederoo, G. Boom (1980) p. 88

    Google Scholar 

  • O. Bostanjoglo, T. Rosin: Ultrasonically induced magnetoelastic effects observed by stroboscopic electron microscopy. In: Proc. 6th Eur. Congr. Electron Microsc., ed. by D.G. Brandon (1976) p. 360

    Google Scholar 

  • O. Bostanjoglo, T. Rosin: Ultrasonically induced magnetic reversals observed by stroboscopic electron-microscopy, Opt. Acta 24, 657 (1977)

    CAS  Google Scholar 

  • O. Bostanjoglo, T. Rosin: Mass and relaxation time of domain walls in thin NiFe films from forced oscillations, J. Magn. Magn. Mater. 1529, 15–18 (1980)

    Google Scholar 

  • O. Bostanjoglo, E. Endruschat: Kinetics of laser-induced crystallization of amorphous germanium films, Phys. Status Solidi (a) 91, 17 (1985)

    CAS  Google Scholar 

  • O. Bostanjoglo, E. Endruschat, W. Tornow: Time-resolved TEM of laser-induced phase transitions in a-Ge and a-Si/Al-films, Mater. Res. Soc. Symp. Proc. 71, 345 (1986)

    CAS  Google Scholar 

  • O. Bostanjoglo, T. Nink: Hydrodynamic instabilities in laser pulse-produced melts of metal films, J. Appl. Phys. 79, 8725 (1996)

    CAS  Google Scholar 

  • O. Bostanjoglo, T. Nink: Liquid motion in laser-pulsed Al, Co, and Au films, Appl. Surf. Sci. 109/110, 101 (1996)

    Google Scholar 

  • O. Bostanjoglo, J. Kornitzky: Nanoseconds double-frame and streak transmission electron microscopy. In: Proc. 12th Int. Congr. Electron Microsc. (1990) p. 180

    Google Scholar 

  • O. Bostanjoglo, J. Kornitzky, R.P. Tornow: High-speed electron-microscopy of laser-induced vaporization of thin-films, J. Appl. Phys. 69, 2581 (1991)

    CAS  Google Scholar 

  • O. Bostanjoglo, R.P. Tornow, W. Tornow: A pulsed image converter for nanosecond electron-microscopy, Scanning Microsc. Suppl. 1, 197 (1987)

    Google Scholar 

  • O. Bostanjoglo, R. Niedrig, B. Wedel: Ablation of metal-films by picosecond laser-pulses imaged with high-speed electron-microscopy, J. Appl. Phys. 76, 3045 (1994)

    CAS  Google Scholar 

  • O. Bostanjoglo, F. Heinricht: Producing high-current nanosecond electron pulses with a standard tungsten hairpin gun, J. Phys. E 120, 1491 (1987)

    Google Scholar 

  • B. Schäfer, O. Bostanjoglo: Laser driven thermionic electron-gun, Optik 92, 9 (1992)

    Google Scholar 

  • O. Bostanjoglo, D. Otte: High-speed transmission electron-microscopy of laser quenching, Mater. Sci. Eng. A 173, 407 (1993)

    Google Scholar 

  • O. Bostanjoglo, D. Otte: High-speed electron-microscopy of nanocrystallization in Al-Ni films by nanosecond laser-pulses, Phys. Status Solidi (a) 150, 163 (1995)

    CAS  Google Scholar 

  • T. Nink, F. Galbert, Z.L. Mao, O. Bostanjoglo: Dynamics of laser pulse-induced melts in Ni-P visualized by high-speed transmission electron microscopy, Appl. Surf. Sci. 139, 439 (1999)

    Google Scholar 

  • T. Nink, Z.L. Mao, O. Bostanjoglo: Melt instability and crystallization in thin amorphous Ni-P films, Appl. Surf. Sci. 154, 140 (2000)

    Google Scholar 

  • H. Dömer, O. Bostanjoglo: Laser ablation of thin films with very high induced stresses, J. Appl. Phys. 91, 5462 (2002)

    Google Scholar 

  • H. Dömer, O. Bostanjoglo: Relaxing melt and plasma bubbles in laser-pulsed metals, J. Appl. Phys. 94, 6280 (2003)

    Google Scholar 

  • T. LaGrange, G.H. Campbell, P.E.A. Turchi, W.E. King: Rapid phase transformation kinetics on a nanoscale: Studies of the \(\upalpha\rightarrow\upbeta\) transformation in pure, nanocrystalline Ti using the nanosecond dynamic transmission electron microscope, Acta Mater. 55, 5211 (2007)

    CAS  Google Scholar 

  • J.S. Kim, T. LaGrange, B.W. Reed, R. Knepper, T.P. Weihs, N.D. Browning, G.H. Campbell: Direct characterization of phase transformations and morphologies in moving reaction zones in Al/Ni nanolaminates using dynamic transmission electron microscopy, Acta Mater. 59, 3571 (2011)

    CAS  Google Scholar 

  • T. LaGrange, D.S. Grummon, B.W. Reed, N.D. Browning, W.E. King, G.H. Campbell: Strongly driven crystallization processes in a metallic glass, Appl. Phys. Lett. 94, 184101 (2009)

    Google Scholar 

  • M.K. Santala, B.W. Reed, S. Raoux, T. Topuria, T. LaGrange, G.H. Campbell: Nanosecond-scale time-resolved electron imaging during laser crystallization of GeTe, Phys. Status Solidi (b) 249, 1907 (2012)

    CAS  Google Scholar 

  • M.K. Santala, S. Raoux, T. Topuria, B.W. Reed, T. LaGrange, G.H. Campbell: Distinguishing mechanisms of morphological instabilities in phase change materials during switching, Thin Solid Films 571, 39 (2014)

    CAS  Google Scholar 

  • M.K. Santala, B.W. Reed, T. Topuria, S. Raoux, S. Meister, Y. Cui, T. LaGrange, G.H. Campbell, N.D. Browning: Nanosecond in situ transmission electron microscope studies of the reversible Ge\({}_{2}\)Sb\({}_{2}\)Te\({}_{5}\) crystalline ⇔ amorphous phase transformation, J. Appl. Phys. 111, 024309 (2012)

    Google Scholar 

  • L. Nikolova, T. LaGrange, B.W. Reed, M.J. Stern, N.D. Browning, G.H. Campbell, J.C. Kieffer, B.J. Siwick, F. Rosei: Nanocrystallization of amorphous germanium films observed with nanosecond temporal resolution, Appl. Phys. Lett. 97, 203102 (2010)

    Google Scholar 

  • L. Nikolova, T. LaGrange, M.J. Stern, J.M. MacLeod, B.W. Reed, H. Ibrahim, G.H. Campbell, F. Rosei, B.J. Siwick: Complex crystallization dynamics in amorphous germanium observed with dynamic transmission electron microscopy, Phys. Rev. B 87, 064105 (2013)

    Google Scholar 

  • G.C. Egan, K.T. Sullivan, T. LaGrange, B.W. Reed, M.R. Zachariah: In situ imaging of ultra-fast loss of nanostructure in nanoparticle aggregates, J. Appl. Phys. 115, 084903 (2014)

    Google Scholar 

  • J.T. McKeown, N.A. Roberts, J.D. Fowlkes, Y. Wu, T. LaGrange, B.W. Reed, G.H. Campbell, P.D. Rack: Real-time observation of nanosecond liquid-phase assembly of nickel nanoparticles via pulsed-laser heating, Langmuir 28, 17168 (2012)

    CAS  Google Scholar 

  • B. Barwick, D.J. Flannigan, A.H. Zewail: Photon-induced near-field electron microscopy, Nature 462, 902 (2009)

    CAS  Google Scholar 

  • G.C. Egan, T. LaGrange, M.R. Zachariah: Time-resolved nanosecond imaging of nanoscale condensed phase reaction, J. Phys. Chem. C 119, 2792 (2015)

    CAS  Google Scholar 

  • T.T. Li, L.B. Bayu Aji, T.W. Heo, M.K. Santala, S.O. Kucheyev, G.H. Campbell: Effect of medium range order on pulsed laser crystallization of amorphous germanium thin films, Appl. Phys. Lett. 108, 221906 (2016)

    Google Scholar 

  • R.M. van der Veen, O.-H. Kwon, A. Tissot, A. Hauser, A.H. Zewail: Single-nanoparticle phase transitions visualized by four-dimensional electron microscopy, Nat. Chem. 5, 395 (2013)

    Google Scholar 

  • D.J. Flannigan, V.A. Lobastov, A.H. Zewail: Controlled nanoscale mechanical phenomena discovered with ultrafast electron microscopy, Angew. Chem. Int. Ed. 46, 9206 (2007)

    CAS  Google Scholar 

  • O.-H. Kwon, V. Ortalan, A.H. Zewail: Macromolecular structural dynamics visualized by pulsed dose control in 4D electron microscopy, Proc. Natl. Acad. Sci. USA 108, 6026 (2011)

    CAS  Google Scholar 

  • A.W.P. Fitzpatrick, S.T. Park, A.H. Zewail: Exceptional rigidity and biomechanics of amyloid revealed by 4D electron microscopy, Proc. Natl. Acad. Sci. USA 110, 10976 (2013)

    CAS  Google Scholar 

  • A.W.P. Fitzpatrick, G.M. Vanacore, A.H. Zewail: Nanomechanics and intermolecular forces of amyloid revealed by four-dimensional electron microscopy, Proc. Natl. Acad. Sci. USA 112, 3380 (2015)

    CAS  Google Scholar 

  • D.J. Flannigan, D.R. Cremons, D.T. Valley: Multimodal visualization of the optomechanical response of silicon cantilevers with ultrafast electron microscopy, J. Mater. Res. 32, 239 (2017)

    CAS  Google Scholar 

  • M.S. Grinolds, V.A. Lobastov, J. Weissenrieder, A.H. Zewail: Four-dimensional ultrafast electron microscopy of phase transitions, Proc. Natl. Acad. Sci. USA 103, 18427 (2006)

    CAS  Google Scholar 

  • V.A. Lobastov, J. Weissenrieder, J. Tang, A.H. Zewail: Ultrafast electron microscopy (UEM): Four-dimensional imaging and diffraction of nanostructures during phase transitions, Nano Lett. 7, 2552 (2007)

    CAS  Google Scholar 

  • O.-H. Kwon, H.S. Park, J.S. Baskin, A.H. Zewail: Nonchaotic nonlinear motion visualized in complex nanostructures by stereographic 4D electron microscopy, Nano Lett. 10, 3190 (2010)

    CAS  Google Scholar 

  • J.S. Baskin, H.S. Park, A.H. Zewail: Nanomusical systems visualized and controlled in 4D electron microscopy, Nano Lett. 11, 2183 (2011)

    CAS  Google Scholar 

  • O.F. Mohammed, P.C. Samartzis, A.H. Zewail: Heating and cooling dynamics of carbon nanotubes by temperature-jump spectroscopy and electron microscopy, J. Am. Chem. Soc. 131, 16010 (2009)

    CAS  Google Scholar 

  • D.J. Flannigan, B. Barwick, A.H. Zewail: Biological imaging with 4D ultrafast electron microscopy, Proc. Natl. Acad. Sci. USA 107, 9933 (2010)

    CAS  Google Scholar 

  • A. Yurtsever, J.S. Baskin, A.H. Zewail: Entangled nanoparticles: Discovery by visualization in 4D electron microscopy, Nano Lett. 12, 5027 (2012)

    CAS  Google Scholar 

  • D.J. Flannigan, A.H. Zewail: Optomechanical and crystallization phenomena visualized with 4D electron microscopy: Interfacial carbon nanotubes on silicon nitride, Nano Lett. 10, 1892 (2010)

    CAS  Google Scholar 

  • U.J. Lorenz, A.H. Zewail: Biomechanics of DNA structures visualized by 4D electron microscopy, Proc. Natl. Acad. Sci. USA 110, 2822 (2013)

    CAS  Google Scholar 

  • J. Hu, G.M. Vanacore, Z. Yang, X. Miao, A.H. Zewail: Transient structures and possible limits of data recording in phase-change materials, ACS Nano 9, 6728 (2015)

    CAS  Google Scholar 

  • B.-K. Yoo, Z. Su, J.M. Thomas, A.H. Zewail: On the dynamical nature of the active center in a single-site photocatalyst visualized by 4D ultrafast electron microscopy, Proc. Natl. Acad. Sci. USA 113, 503 (2016)

    CAS  Google Scholar 

  • D.R. Cremons, D.A. Plemmons, D.J. Flannigan: Femtosecond electron imaging of defect-modulated phonon dynamics, Nat. Commun. 7, 11230 (2016)

    CAS  Google Scholar 

  • D.T. Valley, V.E. Ferry, D.J. Flannigan: Imaging intra- and interparticle acousto-plasmonic vibrational dynamics with ultrafast electron microscopy, Nano Lett. 16, 7302 (2016)

    CAS  Google Scholar 

  • O.-H. Kwon, B. Barwick, H.S. Park, J.S. Baskin, A.H. Zewail: 4D visualization of embryonic, structural crystallization by single-pulse microscopy, Proc. Natl. Acad. Sci. USA 105, 8519 (2008)

    CAS  Google Scholar 

  • H.S. Park, O.-H. Kwon, J.S. Baskin, B. Barwick, A.H. Zewail: Direct observation of martensitic phase-transformation dynamics in iron by 4D single-pulse electron microscopy, Nano Lett. 9, 3953 (2009)

    Google Scholar 

  • F. Carbone, O.-H. Kwon, A.H. Zewail: Dynamics of chemical bonding mapped by energy-resolved 4D electron microscopy, Science 325, 181 (2009)

    CAS  Google Scholar 

  • R.M. van der Veen, T.J. Penfold, A.H. Zewail: Ultrafast core-loss spectroscopy in four-dimensional electron microscopy, Struct. Dyn. 2, 024302 (2015)

    Google Scholar 

  • S.T. Park, A.H. Zewail: Photon-induced near-field electron microscopy: Mathematical formulation of the relation between the experimental observables and the optically driven charge density of nanoparticles, Phys. Rev. A 89, 013851 (2014)

    Google Scholar 

  • H. Liu, J.S. Baskin, A.H. Zewail: Infrared PINEM developed by diffraction in 4D UEM, Proc. Natl. Acad. Sci. USA 113, 2041 (2016)

    CAS  Google Scholar 

  • A. Yurtsever, A.H. Zewail: 4D nanoscale diffraction observed by convergent-beam ultrafast electron microscopy, Science 326, 708 (2009)

    CAS  Google Scholar 

  • A. Yurtsever, A.H. Zewail: Kikuchi ultrafast nanodiffraction in four-dimensional electron microscopy, Proc. Natl. Acad. Sci. USA 108, 3152 (2011)

    CAS  Google Scholar 

  • O.-H. Kwon, A.H. Zewail: 4D electron tomography, Science 328, 1668 (2010)

    CAS  Google Scholar 

  • D.-S. Yang, O.F. Mohammed, A.H. Zewail: Scanning ultrafast electron microscopy, Proc. Natl. Acad. Sci. USA 107, 14993 (2010)

    CAS  Google Scholar 

  • O.F. Mohammed, D.-S. Yang, S.K. Pal, A.H. Zewail: 4D scanning ultrafast electron microscopy: Visualization of materials surface dynamics, J. Am. Chem. Soc. 133, 7708 (2011)

    CAS  Google Scholar 

  • D.-S. Yang, O.F. Mohammed, A.H. Zewail: Environmental scanning ultrafast electron microscopy: Structural dynamics of solvation at interfaces, Angew. Chem. Int. Ed. 52, 2897 (2013)

    CAS  Google Scholar 

  • H.S. Park, J.S. Baskin, A.H. Zewail: 4D Lorentz electron microscopy imaging: Magnetic domain wall nucleation, reversal, and wave velocity, Nano Lett. 10, 3796 (2010)

    CAS  Google Scholar 

  • V. Ortalan, A.H. Zewail: 4D scanning transmission electron microscopy: Single particle imaging and spectroscopy, J. Am. Chem. Soc. 133, 10731 (2011)

    Google Scholar 

  • A. Yurtsever, R.M. van der Veen, A.H. Zewail: Subparticle ultrafast spectrum imaging in 4D electron microscopy, Science 335, 59 (2012)

    CAS  Google Scholar 

  • A.W.P. Fitzpatrick, U.J. Lorenz, G.M. Vanacore, A.H. Zewail: 4D cryo-electron microscopy of proteins, J. Am. Chem. Soc. 135, 19123 (2013)

    CAS  Google Scholar 

  • L. Sterafini: Micro-bunch production with radio frequency photo-injectors, IEEE Trans. Plasma Sci. 24, 421 (1996)

    Google Scholar 

  • L.C. Steinhauer, W.D. Kimura: Longitudinal space charge debunching and compensation in high-frequency accelerators, Phys. Rev. Accel. Beams 2, 081301 (1999)

    Google Scholar 

  • H. Qin, R.C. Davidson: Longitudinal drift compression and pulse shaping for high-intensity particle beams, Phys. Rev. Accel. Beams 5, 034401 (2002)

    Google Scholar 

  • S.G. Anderson, J.B. Rosenzweig, P. Musumeci, M.C. Thompson: Horizontal phase-space distortions arising from magnetic pulse compression of an intense, relativistic electron beam, Phys. Rev. Lett. 91, 074803 (2003)

    CAS  Google Scholar 

  • D.H. Dowell, J.L. Adamski, T.D. Hayward, P.E. Johnson, C.D. Parazzoli, A.M. Vetter: Results of the Boeing pulse compression and energy recovery, Nucl. Instrum. Methods Phys. Res. A 393, 184 (1997)

    CAS  Google Scholar 

  • F. Zhou, D.B. Cline, W.D. Kimura: Beam dynamics analysis of femtosecond microbunches produced by the staged electron laser acceleration experiment, Phys. Rev. Accel. Beams 6, 054201 (2003)

    Google Scholar 

  • P. Kung, H.C. Lihn, H. Wiedmann, D. Bocek: Generation and measurement of 50-fs (rms) electron pulses, Phys. Rev. Lett. 73, 967 (1994)

    CAS  Google Scholar 

  • T. Kozawa, T. Kobayashi, T. Ueda, M. Uesaka: Generation of high-current (1kA) subpicosecond electron single pulse, Nucl. Instrum. Methods Phys. Res. A 399, 180 (1997)

    CAS  Google Scholar 

  • M. Reiser: Theory and Design of Charged Particle Beams (Wiley, New York 1994)

    Google Scholar 

  • G. Taban, M.P. Reijnders, B. Fleskens, S.B. van der Greer, O.J. Luiten, E.J.D. Vredenbregt: Ultracold electron source for single-shot diffraction studies, Europhys. Lett. 91, 46004 (2010)

    Google Scholar 

  • B.J. Claessens, S.B. van der Greer, G. Taban, E.J.D. Vredenbregt, O.J. Luiten: Ultracold electron source, Phys. Rev. Lett. 95, 164801 (2005)

    CAS  Google Scholar 

  • B.J. Claessens, M.P. Reijnders, G. Taban, O.J. Luiten, E.J.D. Vredenbregt: Cold electron and ion beams generated from trapped atoms, Phys. Plasmas 14, 093101 (2007)

    Google Scholar 

  • M.P. Reijnders, P.A. van Kruisbergen, G. Taban, S.B. van der Greer, P.H.A. Mutsaers, E.J.D. Vredenbregt, O.J. Luiten: Low-energy-spread ion bunches from a trapped atomic gas, Phys. Rev. Lett. 102, 034802 (2009)

    CAS  Google Scholar 

  • M.P. Reijnders, N. Debernardi, S.B. van der Greer, P.H.A. Mutsaers, E.J.D. Vredenbregt, O.J. Luiten: Phase-space manipulation of ultracold ion bunches with time-dependent field, Phys. Rev. Lett. 105, 034802 (2010)

    CAS  Google Scholar 

  • D.H. Dowell, J.F. Schmerge: Quantum efficiency and thermal emittance of metal photocathodes, Phys. Rev. Accel. Beams 12, 074201 (2009)

    Google Scholar 

  • N. Debernardi, M.P. Reijnders, W.J. Engelen, T.T.J. Clevis, P.H.A. Mutsaers, O.J. Luiten, E.J.D. Vredenbregt: Measurement of the temperature of an ultracold ion source using time-dependent electric field, J. Appl. Phys. 110, 024501 (2011)

    Google Scholar 

  • A.J. McCulloch, D.V. Sheludko, S.D. Saliba, S.C. Bell, M. Junker, K.A. Nugent, R.E. Scholten: Arbitrarily shaped high-coherence electron bunches from cold atoms, Nat. Phys. 7, 785 (2011)

    CAS  Google Scholar 

  • M.P. Reijnders, N. Debernardi, S.B. van der Greer, P.H.A. Mutsaers, E.J.D. Vredenbregt, O.J. Luiten: Time-dependent manipulation of ultracold ion bunches, J. Appl. Phys. 109, 033302 (2011)

    Google Scholar 

  • E.J.D. Vredenbregt, O.J. Luiten: Electron diffraction: Cool beams in great shape, Nat. Phys. 7, 747 (2011)

    CAS  Google Scholar 

  • W.J. Engelen, M.A. van der Heijden, D.J. Bakker, E.J.D. Vredenbregt, O.J. Luiten: High-coherence electron bunches produced by femtosecond photoionization, Nat. Commun. 4, 1693 (2013)

    CAS  Google Scholar 

  • L. Cultrera, S. Karkare, H. Lee, X. Liu, I. Bazarov, B. Dunham: Cold electron beams from cryocooled, alkali antimonide photocathodes, Phys. Rev. Accel. Beams 18, 113401 (2015)

    Google Scholar 

  • R. Akre, D. Dowell, P. Emma, J. Frisch, S. Gilevich, G. Hays, P. Hering, R. Iverson, C. Limborg-Deprey, H. Loos, A. Miahnahri, J. Schmerge, J. Turner, J. Welch, W. White, J. Wu: Commissioning the linac coherent light source injector, Phys. Rev. Accel. Beams 11, 030703 (2008)

    Google Scholar 

  • A. Chao: Physics of Collective Beam Instabilities in High Energy Accelerators (Wiley, New York 1993)

    Google Scholar 

  • D.A. Edwards, M.J. Syphers: An Introduction to the Physics of High Energy Accelerators (Wiley, New York 1993)

    Google Scholar 

  • J.B. Hastings, F.M. Rudakov, D.H. Dowell, J.F. Schmerge, J.D. Cardoza, J.M. Castro, S.M. Gierman, H. Loos, P.M. Weber: Ultrafast time-resolved electron diffraction with megavolt electron beams, Appl. Phys. Lett. 89, 184109 (2006)

    Google Scholar 

  • R.K. Li, C.X. Tang, Y.C. Du, W.H. Huang, Q. Du, J.R. Shi, X. Yan, X.J. Wang: Experimental demonstration of high quality MeV ultrafast electron diffraction, Rev. Sci. Instrum. 80, 083303 (2009)

    Google Scholar 

  • P. Musumeci, J.T. Moody, C.M. Scoby, M.S. Gutierrez, M. Westfall: Laser-induced melting of a single crystal gold sample by time-resolved ultrafast relativistic electron diffraction, Appl. Phys. Lett. 97, 063502 (2010)

    Google Scholar 

  • Y. Murooka, N. Naruse, S. Sakakihara, M. Ishimaru, J. Yang, K. Tanimura: Transmission-electron diffraction by MeV electron pulses, Appl. Phys. Lett. 98, 251903 (2011)

    Google Scholar 

  • P.F. Zhu, H. Berger, J. Cao, J. Geck, Y. Hidaka, R. Kraus, S. Pjerov, Y. Shen, R.I. Tobey, Y. Zhu, J.P. Hill, X.J. Wang: Femtosecond time-resolved MeV electron diffraction, New J. Phys. 17, 063004 (2015)

    Google Scholar 

  • M.Z. Mo, X. Shen, Z. Chen, R.K. Li, M. Dunning, K. Sokolowski-Tinten, Q. Zheng, S.P. Weathersby, A.H. Reid, R. Coffee, I. Makasyuk, S. Edstrom, D. McCormick, K. Jobe, C. Hast, S.H. Glenzer, X. Wang: Single-shot mega-electron volt ultrafast electron diffraction for structure dynamics of warm dense matter, Rev. Sci. Instrum. 87, 11D810 (2016)

    CAS  Google Scholar 

  • R. Li, P. Musumeci: Single-shot ultrafast electron microscopy. In: 25th North Am. Part. Accel. Conf. (2013)

    Google Scholar 

  • K. Tanimura: Toward ultrafast electron microscope with femtosecond temporal resolution, atomic-level spatial resolution, and single-shot imaging capability, Microsc. Microanal. 21(Suppl. 3), 651 (2015)

    Google Scholar 

  • J. Yang, K. Kan, T. Kondoh, Y. Yoshida, J. Urakawa: RF gun based ultrafast electron microscopy. In: Proc. IPAC2015 (2015), https://doi.org/10.18429/JACoW-IPAC2015-TUPWI008

    Chapter  Google Scholar 

  • B.W. Reed, S.T. Park, D.J. Masiel: Beyond movie mode: Bridging the gap of time resolution, Microsc. Microanal. 22(Suppl. 3), 706 (2016)

    Google Scholar 

  • L.F. Allard, S.H. Overbury, W.C. Bigelow, M.B. Katz, D.P. Nackashi, J. Damiano: Novel MEMS-based gas cell/heating specimen holder provides advanced imaging capabilities for in situ reaction studies, Microsc. Microanal. 18, 656 (2012)

    CAS  Google Scholar 

  • S. Mehraeen, J.T. McKeown, P.V. Deshmukh, J.E. Evans, P. Abellan, P. Xu, B.W. Reed, M.L. Taheri, P.E. Fischione, N.D. Browning: A (S)TEM gas cell holder with localized laser heating for in situ experiments, Microsc. Microanal. 19, 470 (2013)

    CAS  Google Scholar 

  • J.E. Evans, K.L. Jungjohann, N.D. Browning, I. Arslan: Controlled growth of nanoparticles from solution with in situ liquid transmission electron microscopy, Nano Lett. 11, 2809 (2011)

    CAS  Google Scholar 

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Acknowledgements

This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory (LLNL) under Contract No. DE-AC52-07NA27344. Activities and personnel at LLNL were supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Materials Science and Engineering under FWP SCW0974.

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Authors and Affiliations

  1. Materials Science Division, Lawrence Livermore National Laboratory, Livermore, CA, USA

    Geoffrey H. Campbell

  2. Materials Science Division, Lawrence Livermore National Laboratory, Livermore, CA, USA

    Joseph T. McKeown

  3. School of Mechanical, Industrial, and Manufacturing Engineering, Oregon State University, Corvallis, OR, USA

    Melissa K. Santala

Authors
  1. Geoffrey H. Campbell
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  2. Joseph T. McKeown
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  3. Melissa K. Santala
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Correspondence to Geoffrey H. Campbell .

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  1. CEMES-CNRS, Toulouse, France

    Peter W. Hawkes

  2. Dept. of Physics, Arizona State University, Tempe, AZ, USA

    John C. H. Spence

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Campbell, G.H., McKeown, J.T., Santala, M.K. (2019). High-Speed Electron Microscopy. In: Hawkes, P.W., Spence, J.C.H. (eds) Springer Handbook of Microscopy. Springer Handbooks. Springer, Cham. https://doi.org/10.1007/978-3-030-00069-1_8

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