Skip to main content
SpringerLink
Log in
Book cover

The Respiratory Tract in Pediatric Critical Illness and Injury pp 1–6Cite as

Nitric Oxide

  • Chapter
  • First Online:

  • 1083 Accesses

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288(5789):373–376.

    Article  PubMed  CAS  Google Scholar 

  2. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327(6122):524–526.

    Article  PubMed  CAS  Google Scholar 

  3. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84(24):9265–9269.

    Article  PubMed  CAS  Google Scholar 

  4. Stuehr DJ, Gross SS, Sakuma I, Levi R, Nathan CF. Activated murine macrophages secrete a metabolite of arginine with the bioactivity of endothelium-derived relaxing factor and the chemical reactivity of nitric oxide. J Exp Med 1989;169(3):1011–1020.

    Article  PubMed  CAS  Google Scholar 

  5. Snyder SH. Nitric oxide: first in a new class of neurotransmitters. Science 1992;257(5069):494–496.

    Article  PubMed  CAS  Google Scholar 

  6. Bruckdorfer R. The basics about nitric oxide. Mol Aspects Med 2005;26(1–2):3–31.

    Article  PubMed  CAS  Google Scholar 

  7. Tatoyan A, Giulivi C. Purification and characterization of a nitric-oxide synthase from rat liver mitochondria. J Biol Chem 1998;273(18):11044–11048.

    Article  PubMed  CAS  Google Scholar 

  8. Schild L, Reinheckel T, Reiser M, Horn TF, Wolf G, Augustin W. Nitric oxide produced in rat liver mitochondria causes oxidative stress and impairment of respiration after transient hypoxia. FASEB J 2003;17(15):2194–2201.

    Article  PubMed  CAS  Google Scholar 

  9. Kone BC. Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health. Semin Nephrol 2004;24(4):299–315.

    Article  PubMed  CAS  Google Scholar 

  10. Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J 2001;357(Pt 3):593–615.

    Article  PubMed  CAS  Google Scholar 

  11. Kone BC, Kuncewicz T, Zhang W, Yu ZY. Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am J Physiol Renal Physiol 2003;285(2):F178–F190.

    PubMed  CAS  Google Scholar 

  12. Pritchard KA Jr, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, et al. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. J Biol Chem 2001;276(21):1762–1764.

    Article  Google Scholar 

  13. Leiper J, Vallance P. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc Res 1999;43(3):542–548.

    Article  PubMed  CAS  Google Scholar 

  14. Kone BC. Protein-protein interactions controlling nitric oxide synthases. Acta Physiol Scand 2000;168(1):27–31.

    Article  PubMed  CAS  Google Scholar 

  15. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, et al. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 2004;287(4):L656–L664.

    Article  PubMed  CAS  Google Scholar 

  16. Greenacre SA, Ischiropoulos H. Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction. Free Radic Res 2001;34(6):541–581.

    Article  PubMed  CAS  Google Scholar 

  17. Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS. Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol 2005;6(2):150–166.

    Article  PubMed  CAS  Google Scholar 

  18. Foster MW, McMahon TJ, Stamler JS. S-nitrosylation in health and disease. Trends Mol Med 2003;9(4):160–168.

    Article  PubMed  CAS  Google Scholar 

  19. Hare JM, Stamler JS. NO/redox disequilibrium in the failing heart and cardiovascular system. J Clin Invest 2005;115(3):509–517.

    PubMed  CAS  Google Scholar 

  20. Gaston BM, Carver J, Doctor A, Palmer LA. S-nitrosylation signaling in cell biology. Mol Intervent 2003;3(5):253–263.

    Article  CAS  Google Scholar 

  21. McMahon TJ, Moon RE, Luschinger BP, Carraway MS, Stone AE, Stolp BW, et al. Nitric oxide in the human respiratory cycle. Nat Med 2002;8(7):711–717.

    PubMed  CAS  Google Scholar 

  22. Stamler JS. S-nitrosothiols in the blood: roles, amounts, and methods of analysis. Circ Res 2004;94(4):414–417.

    Article  PubMed  CAS  Google Scholar 

  23. Gaston B, Sears S, Woods J, Hunt J, Ponaman M, McMahon T, et al. Bronchodilator S-nitrosothiol deficiency in asthmatic respiratory failure. Lancet 1998;351(9112):1317–1319.

    Article  PubMed  CAS  Google Scholar 

  24. Grasemann H, Gaston B, Fang K, Paul K, Ratjen F. Decreased levels of nitrosothiols in the lower airways of patients with cystic fibrosis and normal pulmonary function. J Pediatr 1999;135(6):770–772.

    Article  PubMed  CAS  Google Scholar 

  25. Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation 1991;83(6):2038–2047.

    PubMed  CAS  Google Scholar 

  26. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension. Lancet 1991;338(8776):1173–1174.

    Article  PubMed  CAS  Google Scholar 

  27. Ichinose F, Roberts JD Jr, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation 2004;109(25):3106–3111.

    Article  PubMed  Google Scholar 

  28. Kinsella JP, Neish SR, Shaffer E, Abman SH. Low-dose inhalation nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340(8823):819–820.

    Article  PubMed  CAS  Google Scholar 

  29. Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992;340(8823):818–819.

    Article  PubMed  CAS  Google Scholar 

  30. Kinsella JP, Neish SR, Ivy DD, Shaffer E, Abman SH. Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide. J Pediatr 1993;123(1):103–108.

    Article  PubMed  CAS  Google Scholar 

  31. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. The Neonatal Inhaled Nitric Oxide Study Group. N Engl J Med 1997;336(9):597–604.

    Article  Google Scholar 

  32. Kinsella JP, Truog WE, Walsh WF, Goldberg RN, Bancalari E, Mayock DE, et al. Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 1997;131(1 Pt 1):55–62.

    PubMed  CAS  Google Scholar 

  33. Rossaint R, Falke KJ, Lopez F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993;328(6):399–405.

    Article  PubMed  CAS  Google Scholar 

  34. Lundin S, Mang H, Smithies M, Stenqvist O, Frostell C. Inhalation of nitric oxide in acute lung injury: results of a European multicentre study. The European Study Group of Inhaled Nitric Oxide. Intensive Care Med 1999;25(9):911–919.

    Article  PubMed  CAS  Google Scholar 

  35. Dellinger RP, Zimmerman JL, Taylor RW, Straube RC, Hauser DL, Criner GJ, et al. Effects of inhaled nitric oxide in patients with acute respiratory distress syndrome: results of a randomized phase II trial. Inhaled Nitric Oxide in ARDS Study Group. Crit Care Med 1998;26(1):15–23.

    Article  PubMed  CAS  Google Scholar 

  36. Abman SH, Griebel JL, Parker DK, Schmidt JM, Swanton D, Kinsella JP. Acute effects of inhaled nitric oxide in children with severe hypoxemic respiratory failure. J Pediatr 1994;124(6):881–888.

    Article  PubMed  CAS  Google Scholar 

  37. Dobyns EL, Cornfield DN, Anas NG, Fortenberry JD, Tasker RC, Lynch A, et al. Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. J Pediatr 1999;134(4):406–412.

    Article  PubMed  CAS  Google Scholar 

  38. Ardehali A, Hughes K, Sadeghi A, Esmailian F, Marelli D, Moriguchi J, et al. Inhaled nitric oxide for pulmonary hypertension after heart transplantation. Transplantation 2001;72(4):638–641.

    Article  PubMed  CAS  Google Scholar 

  39. Humbert M, Sitbon O, Simonneau G. Treatment of pulmonary arterial hypertension. N Engl J Med 2004;351(14):1425–1436.

    Article  PubMed  CAS  Google Scholar 

  40. Celermajer DS, Cullen S, Deanfield JE. Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 1993;87(2):440–446.

    PubMed  CAS  Google Scholar 

  41. Roberts JD, Jr., Lang P, Bigatello LM, Vlahakes GJ, Zapol WM. Inhaled nitric oxide in congenital heart disease. Circulation 1993;87(2):447–453.

    PubMed  Google Scholar 

  42. Goldman AP, Delius RE, Deanfield JE, Miller OI, de Leval MR, Sigston PE, et al. Pharmacological control of pulmonary blood flow with inhaled nitric oxide after the fenestrated Fontan operation. Circulation 1996;94(9 Suppl):II44–II48.

    PubMed  CAS  Google Scholar 

  43. Miller OI, Tang SF, Keech A, Pigott NB, Beller E, Celermajer DS. Inhaled nitric oxide and prevention of pulmonary hypertension after congen-ital heart surgery: a randomised double-blind study. Lancet 2000;356(9240):1464–1469.

    Article  PubMed  CAS  Google Scholar 

  44. Fox-Robichaud A, Payne D, Hasan SU, Ostrovsky L, Fairhead T, Reinhardt P, et al. Inhaled NO as a viable antiadhesive therapy for ischemia/reperfusion injury of distal microvascular beds. J Clin Invest 1998;101(11):2497–2505.

    Article  PubMed  CAS  Google Scholar 

  45. Date H, Triantafillou AN, Trulock EP, Pohl MS, Cooper JD, Patterson GA. Inhaled nitric oxide reduces human lung allograft dysfunction. J Thorac Cardiovasc Surg 1996;111(5):913–919.

    Article  PubMed  CAS  Google Scholar 

  46. Ardehali A, Laks H, Levine M, Shpiner R, Ross D, Watson LD, et al. A prospective trial of inhaled nitric oxide in clinical lung transplantation. Transplantation 2001;72(1):112–115.

    Article  PubMed  CAS  Google Scholar 

  47. Meade MO, Granton JT, Matte-Martyn A, McRae K, Weaver B, Cripps P, et al. A randomized trial of inhaled nitric oxide to prevent ischemia-reperfusion injury after lung transplantation. Am J Respir Crit Care Med 2003;167(11):1483–1489.

    Article  PubMed  Google Scholar 

  48. Ricciardi MJ, Knight BP, Martinez FJ, Rubenfire M. Inhaled nitric oxide in primary pulmonary hypertension: a safe and effective agent for predicting response to nifedipine. J Am Coll Cardiol 1998;32(4):1068–1073.

    Article  PubMed  CAS  Google Scholar 

  49. Balzer DT, Kort HW, Day RW, Corneli HM, Kovalchin JP, Cannon BC, et al. Inhaled nitric oxide as a preoperative test (INOP Test I): the INOP Test Study Group. Circulation 2002;106(12 Suppl 1):I76–I81.

    PubMed  Google Scholar 

  50. Sitbon O, Humbert M, Jagot JL, Taravella O, Fartoukh M, Parent F, et al. Inhaled nitric oxide as a screening agent for safely identifying responders to oral calcium-channel blockers in primary pulmonary hypertension. Eur Respir J 1998;12(2):265–270.

    Article  PubMed  CAS  Google Scholar 

  51. Ivy DD, Parker D, Doran A, Kinsella JP, Abman SH. Acute hemodynamic effects and home therapy using a novel pulsed nasal nitric oxide delivery system in children and young adults with pulmonary hypertension. Am J Cardiol 2003;92(7):886–890.

    Article  PubMed  CAS  Google Scholar 

  52. Dobyns EL, Griebel J, Kinsella JP, Abman SH, Accurso FJ. Infant lung function after inhaled nitric oxide therapy for persistent pulmonary hypertension of the newborn. Pediatr Pulmonol 1999;28(1):24–30.

    Article  PubMed  CAS  Google Scholar 

  53. Rosenberg AA, Kennaugh JM, Moreland SG, Fashaw LM, Hale KA, Torielli FM, et al. Longitudinal follow-up of a cohort of newborn infants treated with inhaled nitric oxide for persistent pulmonary hypertension. J Pediatr 1997;131(1 Pt 1):70–75.

    PubMed  CAS  Google Scholar 

  54. Dobyns EL, Anas NG, Fortenberry JD, Deshpande J, Cornfield DN, Tasker RC, et al. Interactive effects of high-frequency oscillatory ventilation and inhaled nitric oxide in acute hypoxemic respiratory failure in pediatrics. Crit Care Med 2002;30(11):2425–2429.

    Article  PubMed  CAS  Google Scholar 

  55. Kinsella JP, Abman SH. High-frequency oscillatory ventilation augments the response to inhaled nitric oxide in persistent pulmonary hypertension of the newborn: Nitric Oxide Study Group. Chest 1998;114(1 Suppl):100S.

    Article  PubMed  CAS  Google Scholar 

  56. Davidson D, Barefield ES, Kattwinkel J, Dudell G, Damask M, Straube R, et al. Safety of withdrawing inhaled nitric oxide therapy in per-sistent pulmonary hypertension of the newborn. Pediatrics 1999;104(2 Pt 1):231–236.

    Article  PubMed  CAS  Google Scholar 

  57. Ivy DD, Kinsella JP, Ziegler JW, Abman SH. Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease. J Thorac Cardiovasc Surg 1998;115(4):875–882.

    Article  PubMed  CAS  Google Scholar 

  58. Oka M, Ohnishi M, Takahashi H, Soma S, Hasunuma K, Sato K, et al. Altered vasoreactivity in lungs isolated from rats exposed to nitric oxide gas. Am J Physiol 1996;271(3 Pt 1):L419–L424.

    PubMed  CAS  Google Scholar 

  59. Reffelmann T, Kloner RA. Therapeutic potential of phosphodiesterase 5 inhibition for cardiovascular disease. Circulation 2003;108(2):239–244.

    Article  PubMed  Google Scholar 

  60. Ghofrani HA, Wiedemann R, Rose F, Schermuly RT, Olschewski H, Weissmann N, et al. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 2002;360(9337):895–900.

    Article  PubMed  CAS  Google Scholar 

  61. Michelakis E, Tymchak W, Lien D, Webster L, Hashimoto K, Archer S. Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation 2002;105(20):2398–2403.

    Article  PubMed  CAS  Google Scholar 

  62. Prasad S, Wilkinson J, Gatzoulis MA. Sildenafil in primary pulmonary hypertension. N Engl J Med 2000;343(18):1342.

    Article  PubMed  CAS  Google Scholar 

  63. Synder AH, McPherson ME, Hunt JF, Johnson M, Stanker JS, Gaston B. Acute effects of aerosolized S-nitrosogluathione in cystic fibrosis. Am J Respir Crit Care Med 2002:165(7):922–926.

    Google Scholar 

  64. Moya MP, Gow AJ, Califf RM, Goldberg RN, Stamler JS. Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. Lancet 2002:360(9327):141–143.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Critical Care Medicine The Children’s Hospital Denver, University of Colorado Health Sciences Center, Denver, CO, USA

    Emily L. Dobyns MD (Associate Professor of Pediatrics)

  2. Division of Critical Care Medicine The Children’s Hospital Denver, University of Colorado Health Sciences Center, Denver, CO, USA

    Eva N. Grayck MD (Associate Professor of Pediatrics)

Authors
  1. Emily L. Dobyns MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eva N. Grayck MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medical Center, Div. of Critical Care Medicine, Cincinnati Children's Hospital, Burnet Avenue 3333, Cincinnati, 45229, U.S.A.

    Derek S. Wheeler

  2. Medical Center, Div. of Critical Care Medicine, Cincinnati Children's Hospital, Burnet Avenue 3333, Cincinnati, 45229, U.S.A.

    Hector R. Wong

  3. C.S. Mott Children's Hospital , Pediatric Critical Care Medicine , University of Michigan, E. Medical Center Drive 1500, Ann Arbor, 48109-0243, U.S.A.

    Thomas P. Shanley

Rights and permissions

Reprints and permissions

Copyright information

© 2009 Springer-Verlag London

About this chapter

Cite this chapter

Dobyns, E.L., Grayck, E.N. (2009). Nitric Oxide. In: Wheeler, D., Wong, H., Shanley, T. (eds) The Respiratory Tract in Pediatric Critical Illness and Injury. Springer, London. https://doi.org/10.1007/978-1-84800-925-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-84800-925-7_11

  • Published:

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84800-924-0

  • Online ISBN: 978-1-84800-925-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation