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Nutraceutical Potential of Indigenous Plant Foods and Herbs for Treatment of Alcohol-Related Liver Damage

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Alcohol, Nutrition, and Health Consequences

Part of the book series: Nutrition and Health ((NH))

Abstract

Ingestion of ethanol from the alcoholic beverages results in formation of acetaldehyde by the enzyme alcohol dehydrogenase and then into acetic acid by acetaldehyde dehydrogenase. Thus, acetaldehyde is the first metabolic product of ethanol, as well as an intermediate in other metabolic processes, which is more toxic than ethanol and linked to most of the clinical effects of alcohol. It has been shown to increase the risk of developing cirrhosis of the liver, multiple forms of cancer, and alcoholism [1]. It is also known that acetaldehyde readily reacts with amines, and in the case of the exocyclic nitrogens of nucleosides, the primary product [R2 > N–CH(CH3)–OH] has a very reactive hydroxyl group, which rapidly condenses with alcohols to give stable mixed acetals [R2 > N–CH(CH3)–O–C2H5] at ambient temperature [2].

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Authors and Affiliations

  1. Biometry and Nutrition Group, Agharkar Research Institute, G.G.Agarkar Road Vrindavan, 63 Natraj Society Karvenagar, Pune, MH, 411052, India

    Vaishali Agte M.Sc., Ph.D.

  2. Department of Biomedical Sciences, Texas Tech University Health Sciences Center, 1300 S Coulte Suite 400, Amarillo, TX, 79106, USA

    Upendra Raghunath Gumaste Ph.D. Biochemistry

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  1. Vaishali Agte M.Sc., Ph.D.
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  2. Upendra Raghunath Gumaste Ph.D. Biochemistry
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Correspondence to Vaishali Agte M.Sc., Ph.D. .

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  1. Arizona Health Science Center, Mel and Enid Zuckerman College of Public, University of Arizona, 1501 N. Campbell Ave. ROOM 4335, TUCSON, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Agte, V., Gumaste, U.R. (2013). Nutraceutical Potential of Indigenous Plant Foods and Herbs for Treatment of Alcohol-Related Liver Damage. In: Watson, R., Preedy, V., Zibadi, S. (eds) Alcohol, Nutrition, and Health Consequences. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-047-2_37

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