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Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection

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Book cover Rectal Cancer

Part of the book series: Current Clinical Oncology ((CCO))

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Abstract

In the treatment of rectal cancer, surgery is the principal therapeutic modality for cure. Over time, the surgical treatment of rectal cancer has undergone major developments, with differing pathways in the West and the East. In the West, total mesorectal excision (TME) has become the standard, often combined with neoadjuvant or adjuvant treatment. In the East, initiated by Japanese surgeons, the lateral lymph node dissection (LLND) has become the gold standard in cases of advanced rectal cancer, without the use of (neo)adjuvant treatment regimens. Both surgical treatment approaches and nerve-sparing methods are discussed, including analysis of oncologic outcomes (patterns of local recurrence), major complications rates (including anastomotic leakage), and comparison of Eastern and Western adjuvant treatment modalities, as well as future perspectives in surgical approaches to this disease.

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References

  1. Rutten HJ, den Dulk M, Lemmens VE, van de Velde CJ, Marijnen CA. Controversies of total mesorectal excision for rectal cancer in elderly patients. Lancet Oncol. 2008;9((5):494 –501.

    Article  Google Scholar 

  2. Lisfranc J. Mémoire sur l’excision de la partie inférieure du rectum devenue carcinomateuse. [Observation on a cancerous condition of the rectum treated by excision.]. Rev Méd Franc. 1826;2:380; Translated in Dis Colon Rectum 1983;26:694.

    Google Scholar 

  3. Czerny V. Casuistische Mittheilungen aus der Chirurg. Klin zu Heidelberg 1894; 11.

    Google Scholar 

  4. Miles WE. A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon. Lancet. 1908;2:1812–1813.

    Article  Google Scholar 

  5. Lloyd-Davies OV. Lithotomy-Trendelenburg position for resection of rectum and lower pelvic colon. Lancet. 2008;237:74–76.

    Google Scholar 

  6. Hartmann H. Nouveau procédé d’ablation des cancers de la partie terminale du colon pelvien. Strasbourg: Trentieme Congres de Chirurgie; 1921:411.

    Google Scholar 

  7. Dixon CF. Surgical removal of lesions occurring in sigmoid and rectosigmoid. Am J Surg. 1939;46:12–17.

    Article  Google Scholar 

  8. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery – the clue to pelvic recurrence? Br J Surg. 1982;69(10):613–616.

    Article  PubMed  CAS  Google Scholar 

  9. Quirke P, Durdey P, Dixon MF, Williams NS. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet. 1986;2(8514):996–999.

    Article  PubMed  CAS  Google Scholar 

  10. Hirschfeld L, Leveillé J-B. Néurologie. Description et iconographie du systeme nerveux et des organes des sens de l’homme avec leur mode de preparation. 1st ed. Paris: Baillière; 1853.

    Google Scholar 

  11. Enker WE, Thaler HT, Cranor ML, Polyak T. Total mesorectal excision in the operative treatment of carcinoma of the rectum. J Am Coll Surg. 1995;181(4):335–346.

    PubMed  CAS  Google Scholar 

  12. Havenga K, Enker WE, McDermott K, Cohen AM, Minsky BD, Guillem J. Male and female sexual and urinary function after total mesorectal excision with autonomic nerve preservation for carcinoma of the rectum. J Am Coll Surg. 1996;182(6):495–502.

    PubMed  CAS  Google Scholar 

  13. Maas CP, Moriya Y, Steup WH, Kiebert GM, Kranenbarg WM, van de Velde CJ. Radical and nerve-preserving surgery for rectal cancer in The Netherlands: a prospective study on morbidity and functional outcome. Br J Surg. 1998;85(1):92–97.

    Article  PubMed  CAS  Google Scholar 

  14. Leveckis J, Boucher NR, Parys BT, Reed MW, Shorthouse AJ, Anderson JB. Bladder and erectile dysfunction before and after rectal surgery for cancer. Br J Urol. 1995;76(6):752–756.

    PubMed  CAS  Google Scholar 

  15. Junginger T, Kneist W, Heintz A. Influence of identification and preservation of pelvic autonomic nerves in rectal cancer surgery on bladder dysfunction after total mesorectal excision. Dis Colon Rectum. 2003;46(5):621–628.

    Article  PubMed  CAS  Google Scholar 

  16. Vironen JH, Kairaluoma M, Aalto AM, Kellokumpu IH. Impact of functional results on quality of life after rectal cancer surgery. Dis Colon Rectum. 2006;49(5):568–578.

    Article  PubMed  Google Scholar 

  17. Pollack J, Holm T, Cedermark B, et al. Late adverse effects of short-course preoperative radiotherapy in rectal cancer. Br J Surg. 2006;93(12):1519–1525.

    Article  PubMed  CAS  Google Scholar 

  18. Lange MM, Maas CP, Marijnen CA, et al. Urinary dysfunction after rectal cancer treatment is mainly caused by surgery. Br J Surg. 2008;95(8):1020–1028.

    Article  PubMed  CAS  Google Scholar 

  19. Moriya Y. Function preservation in rectal cancer surgery. Int J Clin Oncol. 2006;11(5):339–343.

    Article  PubMed  Google Scholar 

  20. Daniels IR, Woodward S, Taylor FG, Raja A, Toomey P. Female urogenital dysfunction following total mesorectal excision for rectal cancer. World J Surg Oncol. 2006;4:6.

    Article  PubMed  Google Scholar 

  21. Wallner C, Maas CP, Dabhoiwala NF, Lamers WH, DeRuiter MC. Innervation of the pelvic floor muscles: a reappraisal for the levator ani nerve. Obstet Gynecol. 2006;108(3 Pt 1):529–534.

    Article  PubMed  Google Scholar 

  22. Hendren SK, O’Connor BI, Liu M, et al. Prevalence of male and female sexual dysfunction is high following surgery for rectal cancer. Ann Surg. 2005;242(2):212–223.

    Article  PubMed  Google Scholar 

  23. Marijnen CA, van de Velde CJ, Putter H, et al. Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol. 2005;23(9):1847–1858.

    Article  PubMed  Google Scholar 

  24. Havenga K, Enker WE. Autonomic nerve preserving total mesorectal excision. Surg Clin North Am. 2002;82(5):1009–1018.

    Article  PubMed  Google Scholar 

  25. Dahlberg M, Glimelius B, Graf W, Pahlman L. Preoperative irradiation affects functional results after surgery for rectal cancer: results from a randomized study. Dis Colon Rectum. 1998;41(5):543–549.

    Article  PubMed  CAS  Google Scholar 

  26. Peeters KC, van de Velde CJH, Leer JW, et al. Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients – a Dutch colorectal cancer group study. J Clin Oncol. 2005;23(25):6199–6206.

    Article  PubMed  CAS  Google Scholar 

  27. Welsh FK, McFall M, Mitchell G, Miles WF, Woods WG. Pre-operative short-course radiotherapy is associated with faecal incontinence after anterior resection. Colorectal Dis. 2003;5(6):563–568.

    Article  PubMed  CAS  Google Scholar 

  28. Williams N, Seow-Choen F. Physiological and functional outcome following ultra-low anterior resection with colon pouch-anal anastomosis. Br J Surg. 1998;85(8):1029–1035.

    Article  PubMed  CAS  Google Scholar 

  29. Nesbakken A, Nygaard K, Lunde OC. Outcome and late functional results after anastomotic leakage following mesorectal excision for rectal cancer. Br J Surg. 2001;88(3):400–404.

    Article  PubMed  CAS  Google Scholar 

  30. Wallner C, Lange MM, Bonsing BA, et al. Causes of fecal and urinary incontinence after total mesorectal excision for rectal cancer based on cadaveric surgery: a study from the Cooperative Clinical Investigators of the Dutch total mesorectal excision trial. J Clin Oncol. 2008;26(27):4466–4472.

    Article  PubMed  Google Scholar 

  31. Carlsen E, Schlichting E, Guldvog I, Johnson E, Heald RJ. Effect of the introduction of total mesorectal excision for the treatment of rectal cancer. Br J Surg. 1998;85(4):526–529.

    Article  PubMed  CAS  Google Scholar 

  32. Peeters KC, Tollenaar RA, Marijnen CA, et al. Risk factors for anastomotic failure after total mesorectal excision of rectal cancer. Br J Surg. 2005;92(2):211–216.

    Article  PubMed  CAS  Google Scholar 

  33. Law WL, Choi HK, Lee YM, Ho JW, Seto CL. Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg. 2007;11(1):8–15.

    Article  PubMed  Google Scholar 

  34. Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M. Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg. 1998;85(3):355–358.

    Article  PubMed  CAS  Google Scholar 

  35. Matthiessen P, Hallbook O, Rutegard J, Simert G, Sjodahl R. Defunctioning stoma reduces symptomatic anastomotic leakage after low anterior resection of the rectum for cancer: a randomized multicenter trial. Ann Surg. 2007;246(2):207–214.

    Article  PubMed  Google Scholar 

  36. Vignali A, Fazio VW, Lavery IC, et al. Factors associated with the occurrence of leaks in stapled rectal anastomoses: a review of 1,014 patients. J Am Coll Surg. 1997;185(2):105–113.

    PubMed  CAS  Google Scholar 

  37. Bokey EL, Chapuis PH, Fung C, et al. Postoperative morbidity and mortality following resection of the colon and rectum for cancer. Dis Colon Rectum. 1995;38(5):480–486.

    Article  PubMed  CAS  Google Scholar 

  38. Folkesson J, Nilsson J, Pahlman L, Glimelius B, Gunnarsson U. The circular stapling device as a risk factor for anastomotic leakage. Colorectal Dis. 2004;6(4):275–279.

    Article  PubMed  CAS  Google Scholar 

  39. Poon RT, Chu KW, Ho JW, Chan CW, Law WL, Wong J. Prospective evaluation of selective defunctioning stoma for low anterior resection with total mesorectal excision. World J Surg. 1999;23(5):463–467.

    Article  PubMed  CAS  Google Scholar 

  40. Graf W, Ekstrom K, Glimelius B, Pahlman L. A pilot study of factors influencing bowel function after colorectal anastomosis. Dis Colon Rectum. 1996;39(7):744–749.

    Article  PubMed  CAS  Google Scholar 

  41. Eriksen MT, Wibe A, Norstein J, Haffner J, Wiig JN. Anastomotic leakage following routine mesorectal excision for rectal cancer in a national cohort of patients. Colorectal Dis. 2005;7(1):51–57.

    Article  PubMed  CAS  Google Scholar 

  42. Swedish Rectal Cancer Trial. Improved survival with preoperative radiotherapy in resectable rectal cancer. N Engl J Med. 1997;336(14):980–987.

    Article  Google Scholar 

  43. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001;345(9):638–646.

    Article  PubMed  CAS  Google Scholar 

  44. Stockholm Colorectal Cancer Study Group. Randomized study on preoperative radiotherapy in rectal carcinoma. Ann Surg Oncol. 1996;3(5):423–430.

    Article  Google Scholar 

  45. McArdle CS, McMillan DC, Hole DJ. Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. Br J Surg. 2005;92(9):1150–1154.

    Article  PubMed  CAS  Google Scholar 

  46. Branagan G, Finnis D. Prognosis after anastomotic leakage in colorectal surgery. Dis Colon Rectum. 2005;48(5):1021–1026.

    Article  PubMed  Google Scholar 

  47. Petersen S, Freitag M, Hellmich G, Ludwig K. Anastomotic leakage: impact on local recurrence and survival in surgery of colorectal cancer. Int J Colorectal Dis. 1998;13(4):160–163.

    Article  PubMed  CAS  Google Scholar 

  48. den Dulk M, Marijnen CA, Colette L, Putter H, Pahlman L, Folkesson J et al. Anastomotic leakage associated with long-term reduced overall survival: the results of a pooled analysis of five European randomized clinical trials on rectal cancer. Submitted 2008.

    Google Scholar 

  49. Umpleby HC, Fermor B, Symes MO, Williamson RC. Viability of exfoliated colorectal carcinoma cells. Br J Surg. 1984;71(9):659–663.

    Article  PubMed  CAS  Google Scholar 

  50. Skipper D, Cooper AJ, Marston JE, Taylor I. Exfoliated cells and in vitro growth in colorectal cancer. Br J Surg. 1987;74(11):1049–1052.

    Article  PubMed  CAS  Google Scholar 

  51. Abramovitch R, Marikovsky M, Meir G, Neeman M. Stimulation of tumour growth by wound-derived growth factors. Br J Cancer. 1999;79(9–10):1392–1398.

    Article  PubMed  CAS  Google Scholar 

  52. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet. 2001;357(9255):539–545.

    Article  PubMed  CAS  Google Scholar 

  53. Kusters M, van de Velde CJ, Beets-Tan RG, et al. Patterns of local recurrence in rectal cancer at or below the peritoneal reflection: a single-center experience. Ann Surg Oncol. 2008;16(2):289–296.

    Article  PubMed  Google Scholar 

  54. Kapiteijn E, Kranenbarg EK, Steup WH, et al. Total mesorectal excision (TME) with or without preoperative radiotherapy in the treatment of primary rectal cancer. Prospective randomised trial with standard operative and histopathological techniques. Dutch ColoRectal Cancer Group. Eur J Surg. 1999;165(5):410–420.

    Article  PubMed  CAS  Google Scholar 

  55. Peeters KC, Marijnen CA, Nagtegaal ID, et al. The TME trial after a median follow-up of 6 years: increased local control but no survival benefit in irradiated patients with resectable rectal carcinoma. Ann Surg. 2007;246(5):693–701.

    Article  PubMed  Google Scholar 

  56. Kusters M, Marijnen CA, van de Velde CJ, Rutten HJ, Lahaye MJ, Kim JH, Beets-Tan RG, Beets GL. Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial. Eur J Surg Oncl. 2010 Jan 20. [Epub ahead of print].

    Google Scholar 

  57. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol. 2008;26(2):303–312.

    Article  PubMed  Google Scholar 

  58. Kusters M, Beets GL, van de Velde CJ, et al. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, with focus on the patterns of local recurrence. Ann Surg. 2009;249(2):229–235.

    Article  PubMed  Google Scholar 

  59. Beets-Tan RG, Beets GL. Rectal cancer: review with emphasis on MR imaging. Radiology. 2004;232(2):335–346.

    Article  PubMed  Google Scholar 

  60. Brown G. Thin section MRI in multidisciplinary pre-operative decision making for patients with rectal cancer. Br J Radiol. 2005;78(Spec No 2):S117-S127.

    Article  PubMed  Google Scholar 

  61. Bosset JF, Calais G, Mineur L, et al. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results – EORTC 22921. J Clin Oncol. 2005;23(24):5620–5627.

    Article  PubMed  CAS  Google Scholar 

  62. Burton S, Brown G, Daniels IR, Norman AR, Mason B, Cunningham D. MRI directed multidisciplinary team preoperative treatment strategy: the way to eliminate positive circumferential margins? Br J Cancer. 2006;94(3):351–357.

    Article  PubMed  CAS  Google Scholar 

  63. Kim JH, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG. High-resolution MR imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur J Radiol. 2004;52(1):78–83.

    Article  PubMed  Google Scholar 

  64. Zhao GP, Zhou ZG, Lei WZ, et al. Pathological study of distal mesorectal cancer spread to determine a proper distal resection margin. World J Gastroenterol. 2005;11(3):319–322.

    PubMed  Google Scholar 

  65. Wang Z, Zhou Z, Wang C, et al. Microscopic spread of low rectal cancer in regions of the mesorectum: detailed pathological assessment with whole-mount sections. Int J Colorectal Dis. 2005;20(3):231–237.

    Article  PubMed  CAS  Google Scholar 

  66. Chen W, Shen W, Chen M, Cai G, Liu X. Study on the relationship between lymphatic vessel density and distal intramural spread of rectal cancer. Eur Surg Res. 2007;39(6):332–339.

    Article  PubMed  CAS  Google Scholar 

  67. Koh DM, Brown G, Temple L, et al. Distribution of mesorectal lymph nodes in rectal cancer: in vivo MR imaging compared with histopathological examination. Initial observations. Eur Radiol. 2005;15(8):1650–1657.

    Article  PubMed  CAS  Google Scholar 

  68. Perez RO, Seid VE, Bresciani EH, et al. Distribution of lymph nodes in the mesorectum: how deep is TME necessary? Tech Coloproctol. 2008;12(1):39–43.

    Article  PubMed  CAS  Google Scholar 

  69. Heald RJ, Moran BJ, Ryall RD, Sexton R, MacFarlane JK. Rectal cancer: the Basingstoke experience of total mesorectal excision, 1978-1997. Arch Surg. 1998;133(8):894–899.

    Article  PubMed  CAS  Google Scholar 

  70. Salerno G, Sinnatamby C, Branagan G, Daniels IR, Heald RJ, Moran BJ. Defining the rectum: surgically, radiologically and anatomically. Colorectal Dis. 2006;8(Suppl 3):5–9.

    Article  PubMed  Google Scholar 

  71. den Dulk M, Marijnen CA, Putter H, et al. Risk factors for adverse outcome in patients with rectal cancer treated with an abdominoperineal resection in the total mesorectal excision trial. Ann Surg. 2007;246(1):83–90.

    Article  Google Scholar 

  72. Holm T, Ljung A, Haggmark T, Jurell G, Lagergren J. Extended abdominoperineal resection with gluteus maximus flap reconstruction of the pelvic floor for rectal cancer. Br J Surg. 2007;94(2):232–238.

    Article  PubMed  CAS  Google Scholar 

  73. Valentini V, Coco C, Cellini N, et al. Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer: acute toxicity, tumor response, sphincter preservation. Int J Radiat Oncol Biol Phys. 1999;45(5):1175–1184.

    Article  PubMed  CAS  Google Scholar 

  74. Roels S, Duthoy W, Haustermans K, et al. Definition and delineation of the clinical target volume for rectal cancer. Int J Radiat Oncol Biol Phys. 2006;65(4):1129–1142.

    Article  PubMed  Google Scholar 

  75. Bosset JF, Collette L, Calais G, et al. Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med. 2006;355(11):1114–1123.

    Article  PubMed  CAS  Google Scholar 

  76. den Dulk M, Krijnen P, Marijnen CA, et al. Improved overall survival for patients with rectal cancer since 1990: the effects of TME surgery and pre-operative radiotherapy. Eur J Cancer. 2008;44(12):1710–1716.

    Article  Google Scholar 

  77. Lange MM, den Dulk M, Bossema ER, et al. Risk factors for faecal incontinence after rectal cancer treatment. Br J Surg. 2007;94(10):1278–1284.

    Article  PubMed  CAS  Google Scholar 

  78. Rutten H, den Dulk M, Lemmens V, et al. Survival of elderly rectal cancer patients not improved: analysis of population based data on the impact of TME surgery. Eur J Cancer. 2007;43(15):2295–2300.

    Article  PubMed  Google Scholar 

  79. Beets-Tan RG, Beets GL, Vliegen RF, et al. Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet. 2001;357(9255):497–504.

    Article  PubMed  CAS  Google Scholar 

  80. Lahaye MJ, Engelen SM, Kessels AG, et al. USPIO-enhanced MR imaging for nodal staging in patients with primary rectal cancer: predictive criteria. Radiology. 2008;246(3):804–811.

    Article  PubMed  Google Scholar 

  81. de Heer P, de Bruin EC, Klein-Kranenbarg E, et al. Caspase-3 activity predicts local recurrence in rectal cancer. Clin Cancer Res. 2007;13(19):5810–5815.

    Article  PubMed  CAS  Google Scholar 

  82. Nagtegaal ID, Gosens MJ, Marijnen CA, Rutten HJ, van de Velde CJH, van Krieken JH. Combinations of tumor and treatment parameters are more discriminative for prognosis than the present TNM system in rectal cancer. J Clin Oncol. 2007;25(13):1647–1650.

    Article  PubMed  Google Scholar 

  83. Habr-Gama A, Perez RO, Nadalin W, et al. Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: long-term results. Ann Surg. 2004;240(4):711–717.

    PubMed  Google Scholar 

  84. Gerota D. Die lymphgefasse des rectums und des anus. Arch Anat Physiol. 1895;181:240.

    Google Scholar 

  85. Waugh JM, Kirklin JW. The importance of the level of the lesion in the prognosis and treatment of carcinoma of the rectum and low sigmoid colon. Ann Surg. 1949;129(1):22–33.

    Article  PubMed  CAS  Google Scholar 

  86. Sunderland DA. The significance of vein invasion by cancer of the rectum and sigmoid; a microscopic study of 210 cases. Cancer. 1949;2(3):429–437.

    Article  PubMed  CAS  Google Scholar 

  87. Wangsteen OH. Primary resection of the colon and rectum with particular reference to cancer and ulcerative colitis. Am J Surg. 1948;75:384.

    Article  Google Scholar 

  88. Villemin F. Recherches anatomiques sur les lymphatiques du rectum et l’anus: leur applications dans le traitement chirurgical du cancer. Rev Chir. 1925;63:39–80.

    Google Scholar 

  89. Oliviera E. Observacao sobre os linfaticos anoretais. Tese Rio de Janeiro 1947;77.

    Google Scholar 

  90. Coller FA, Kay EB, Macintyre RS. Regional lymphatic metastases of carcinoma of the colon. Ann Surg. 1941;114(1):56–67.

    Article  PubMed  CAS  Google Scholar 

  91. Dukes WC. The surgical pathology of rectal cancer. Proc R Soc Med. 1943;37:131.

    Google Scholar 

  92. Sauer I, Bacon HE. Influence of lateral spread of cancer of the rectum on radicability of operation and prognosis. Am J Surg. 1951;81(1):111–120.

    Article  PubMed  CAS  Google Scholar 

  93. Stearns MW Jr, Deddish MR. Five-year results of abdominopelvic lymph node dissection for carcinoma of the rectum. Dis Colon Rectum. 1959;2(2):169–172.

    Article  PubMed  Google Scholar 

  94. Enker WE, Pilipshen SJ, Heilweil ML, et al. En bloc pelvic lymphadenectomy and sphincter preservation in the surgical management of rectal cancer. Ann Surg. 1986;203(4):426–433.

    Article  PubMed  CAS  Google Scholar 

  95. Glass RE, Ritchie JK, Thompson HR, Mann CV. The results of surgical treatment of cancer of the rectum by radical resection and extended abdomino-iliac lymphadenectomy. Br J Surg. 1985;72(8):599–601.

    Article  PubMed  CAS  Google Scholar 

  96. Michelassi F, Block GE. Morbidity and mortality of wide pelvic lymphadenectomy for rectal adenocarcinoma. Dis Colon Rectum. 1992;35(12):1143–1147.

    Article  PubMed  CAS  Google Scholar 

  97. Senba Y. An anatomical study of the lymphatic system of the rectum. J Hukuoka Med Coll. 1927;20:1213–1268.

    Google Scholar 

  98. Kuru M. Cancer of the rectum. J Jpn Surg Soc. 1940;41:832–877.

    Google Scholar 

  99. Koyama Y. Extended surgery for rectal cancer. Geka Chiryo. 1977;36:41–45.

    Google Scholar 

  100. Hojo K, Koyama Y. Postoperative follow-up studies on cancer of the colon and rectum. Am J Surg. 1982;143(3):293.

    Article  PubMed  CAS  Google Scholar 

  101. Hojo K, Sawada T, Moriya Y. An analysis of survival and voiding, sexual function after wide iliopelvic lymphadenectomy in patients with carcinoma of the rectum, compared with conventional lymphadenectomy. Dis Colon Rectum. 1989;32(2):128–133.

    Article  PubMed  CAS  Google Scholar 

  102. Sato K, Sato T. The vascular and neuronal composition of the lateral ligament of the rectum and the rectosacral fascia. Surg Radiol Anat. 1991;13(1):17–22.

    Article  PubMed  CAS  Google Scholar 

  103. Hojo K, Vernava AM III, Sugihara K, Katumata K. Preservation of urine voiding and sexual function after rectal cancer surgery. Dis Colon Rectum. 1991;34(7):532–539.

    Article  PubMed  CAS  Google Scholar 

  104. Moriya Y, Sugihara K, Akasu T, Fujita S. Nerve-sparing surgery with lateral node dissection for advanced lower rectal cancer. Eur J Cancer. 1995;31A(7–8):1229–1232.

    Article  PubMed  CAS  Google Scholar 

  105. Moriya Y, Sugihara K, Akasu T, Fujita S. Patterns of recurrence after nerve-sparing surgery for rectal adenocarcinoma with special reference to loco-regional recurrence. Dis Colon Rectum. 1995;38(11):1162–1168.

    Article  PubMed  CAS  Google Scholar 

  106. Sugihara K, Moriya Y, Akasu T, Fujita S. Pelvic autonomic nerve preservation for patients with rectal carcinoma. Oncologic and functional outcome. Cancer. 1996;78(9):1871–1880.

    Article  PubMed  CAS  Google Scholar 

  107. Mori T, Takahashi K, Yasuno M. Radical resection with autonomic nerve preservation and lymph node dissection techniques in lower rectal cancer surgery and its results: the impact of lateral lymph node dissection. Langenbecks Arch Surg. 1998;383(6):409–415.

    Article  PubMed  CAS  Google Scholar 

  108. Matsumoto T, Ohue M, Sekimoto M, Yamamoto H, Ikeda M, Monden M. Feasibility of autonomic nerve-preserving surgery for advanced rectal cancer based on analysis of micrometastases. Br J Surg. 2005;92(11):1444–1448.

    Article  PubMed  CAS  Google Scholar 

  109. Sugihara K, Kobayashi H, Kato T, et al. Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum. 2006;49(11):1663–1672.

    Article  PubMed  Google Scholar 

  110. Martling A, Holm T, Johansson H, Rutqvist LE, Cedermark B. The Stockholm II trial on preoperative radiotherapy in rectal carcinoma: long-term follow-up of a population-based study. Cancer. 2001;92(4):896–902.

    Article  PubMed  CAS  Google Scholar 

  111. Japanese Research Society for Cancer of the Colon and Rectum. General rules for clinical and pathological studies on cancer of the colon, rectum and anus. 7th ed. Tokyo: Kanehira-Syuppan; 2006.

    Google Scholar 

  112. Najarian MM, Belzer GE, Cogbill TH, Mathiason MA. Determination of the peritoneal reflection using intraoperative proctoscopy. Dis Colon Rectum. 2004;47(12):2080–2085.

    Article  PubMed  Google Scholar 

  113. Quirke P. Training and quality assurance for rectal cancer: 20 years of data is enough. Lancet Oncol. 2003;4(11):695–702.

    Article  PubMed  Google Scholar 

  114. Maas CP, Moriya Y, Steup WH, Klein KE, van de Velde CJ. A prospective study on radical and nerve-preserving surgery for rectal cancer in the Netherlands. Eur J Surg Oncol. 2000;26(8):751–757.

    Article  PubMed  CAS  Google Scholar 

  115. Feinstein AR, Sosin DM, Wells CK. The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer. N Engl J Med. 1985;312(25):1604–1608.

    Article  PubMed  CAS  Google Scholar 

  116. Steup WH. Chapter 6: Historical comparison Japanese data NCCH; Comparison between Japan and the Netherlands. Thesis: Colorectal cancer surgery with emphasis on lymphadenectomy1994;83–100.

  117. Japanese Research Society for Cancer of the Colon and Rectum. General rules for clinical and pathological studies on cancer of the colon, rectum and anus. Part I. Clinical classification. Jpn J Surg. 1983;13(6):557–573.

    Article  Google Scholar 

  118. Kyo K, Sameshima S, Takahashi M, Furugori T, Sawada T. Impact of autonomic nerve preservation and lateral node dissection on male urogenital function after total mesorectal excision for lower rectal cancer. World J Surg. 2006;30(6):1014–1019.

    Article  PubMed  Google Scholar 

  119. Yano H, Moran BJ. The incidence of lateral pelvic side-wall nodal involvement in low rectal cancer may be similar in Japan and the West. Br J Surg. 2008;95(1):33–49.

    Article  PubMed  CAS  Google Scholar 

  120. Moriya Y, Sugihara K, Akasu T, Fujita S. Importance of extended lymphadenectomy with lateral node dissection for advanced lower rectal cancer. World J Surg. 1997;21(7):728–732.

    Article  PubMed  CAS  Google Scholar 

  121. Saha S, Seghal R, Patel M, et al. A multicenter trial of sentinel lymph node mapping in colorectal cancer: prognostic implications for nodal staging and recurrence. Am J Surg. 2006;191(3):305–310.

    Article  PubMed  Google Scholar 

  122. Stojadinovic A, Nissan A, Protic M, et al. Prospective randomized study comparing sentinel lymph node evaluation with standard pathologic evaluation for the staging of colon carcinoma: results from the United States Military Cancer Institute Clinical Trials Group Study GI-01. Ann Surg. 2007;245(6):846–857.

    Article  PubMed  Google Scholar 

  123. Quadros CA, Lopes A, Araujo I, Fahel F, Bacellar MS, Dias CS. Retroperitoneal and lateral pelvic lymphadenectomy mapped by lymphoscintigraphy and blue dye for rectal adenocarcinoma staging: preliminary results. Ann Surg Oncol. 2006;13(12):1617–1621.

    Article  PubMed  Google Scholar 

  124. Funahashi K, Koike J, Shimada M, Okamoto K, Goto T, Teramoto T. A preliminary study of the draining lymph node basin in advanced lower rectal cancer using a radioactive tracer. Dis Colon Rectum. 2006;49(10 Suppl):S53-S58.

    Article  PubMed  Google Scholar 

  125. Kawahara H, Nimura H, Watanabe K, Kobayashi T, Kashiwagi H, Yanaga K. Where does the first lateral pelvic lymph node receive drainage from? Dig Surg. 2007;24(6):413–417.

    Article  PubMed  Google Scholar 

  126. Watanabe T, Tsurita G, Muto T, et al. Extended lymphadenectomy and preoperative radiotherapy for lower rectal cancers. Surgery. 2002;132(1):27–33.

    Article  PubMed  Google Scholar 

  127. Kim JC, Takahashi K, Yu CS, et al. Comparative outcome between chemoradiotherapy and lateral pelvic lymph node dissection following total mesorectal excision in rectal cancer. Ann Surg. 2007;246(5):754–762.

    Article  PubMed  Google Scholar 

  128. Watanabe T, Matsuda K, Nozawa K, Kobunai T. Lateral pelvic lymph node dissection or chemoradiotherapy: which is the procedure of choice to reduce local recurrence rate in lower rectal cancer? Ann Surg. 2008;248(2):342–343.

    Article  PubMed  Google Scholar 

  129. Masui H, Ike H, Yamaguchi S, Oki S, Shimada H. Male sexual function after autonomic nerve-preserving operation for rectal cancer. Dis Colon Rectum. 1996;39(10):1140–1145.

    Article  PubMed  CAS  Google Scholar 

  130. Ameda K, Kakizaki H, Koyanagi T, Hirakawa K, Kusumi T, Hosokawa M. The long-term voiding function and sexual function after pelvic nerve-sparing radical surgery for rectal cancer. Int J Urol. 2005;12(3):256–263.

    Article  PubMed  Google Scholar 

  131. Maeda K, Maruta M, Utsumi T, Sato H, Toyama K, Matsuoka H. Bladder and male sexual functions after autonomic nerve-sparing TME with or without lateral node dissection for rectal cancer. Tech Coloproctol. 2003;7(1):29–33.

    Article  PubMed  CAS  Google Scholar 

  132. Matsuoka H, Masaki T, Sugiyama M, Atomi Y. Impact of lateral pelvic lymph node dissection on evacuatory and urinary functions following low anterior resection for advanced rectal carcinoma. Langenbecks Arch Surg. 2005;390(6):517–522.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands

    Miranda Kusters MSc & Cornelis J. H. van de Velde MD, PhD

  2. Department of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan

    Yoshihiro Moriya MD

  3. Department of Surgery, Catherina Hospital, Eindhoven, The Netherlands

    Harm J. T. Rutten PhD

Authors
  1. Miranda Kusters MSc
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  2. Yoshihiro Moriya MD
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  3. Harm J. T. Rutten PhD
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  4. Cornelis J. H. van de Velde MD, PhD
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Editor information

Editors and Affiliations

  1. Dept. Radiation Oncology, Duke University Medical Center, Durham, USA

    Brian G. Czito

  2. Dept. Radiation Oncology, Duke University Medical Center, Durham, USA

    Christopher G. Willett

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Kusters, M., Moriya, Y., Rutten, H.J.T., van de Velde, C.J.H. (2010). Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection. In: Czito, B., Willett, C. (eds) Rectal Cancer. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-567-5_4

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  • DOI: https://doi.org/10.1007/978-1-60761-567-5_4

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