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DNA Replication Initiation

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DNA Replication

Part of the book series: Methods in Molecular Biology ((MIMB,volume 521))

Summary

DNA replication is fundamental to cellular life on earth, and replication initiation provides the primary point of control over this process. Replication initiation in all organisms involves the interaction of initiator proteins with one or more origins of replication in the DNA, with subsequent regulated assembly of two replisome complexes at each origin, melting of the DNA, and primed initiation of DNA synthesis on leading and lagging strands. Archaea and Eukarya share homologous systems for DNA replication initiation, but differ in the complexity of these; Bacteria appear to have analogous, rather than homologous, mechanisms for replication initiation. This chapter provides an overview of current knowledge of initiation of chromosomal DNA replication in the three domains of life.

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Acknowledgements

I would like to thank Karen Moore for helpful comments on this chapter and to apologise to the many authors whose work I have not been able to refer to because of space limitations in this outline review.

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  1. School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, UK

    Stephen J. Aves

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  1. Stephen J. Aves
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Correspondence to Stephen J. Aves .

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  1. Marie Curie Research Institute, The Chart, Oxted, RH 8 0TL, United Kingdom

    Sonya Vengrova

  2. Marie Curie Research Institute, The Chart, Oxted, RH 8 0TL, United Kingdom

    Jacob Z. Dalgaard

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Aves, S.J. (2009). DNA Replication Initiation. In: Vengrova, S., Dalgaard, J. (eds) DNA Replication. Methods in Molecular Biology, vol 521. Humana Press. https://doi.org/10.1007/978-1-60327-815-7_1

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  • DOI: https://doi.org/10.1007/978-1-60327-815-7_1

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  • Print ISBN: 978-1-60327-814-0

  • Online ISBN: 978-1-60327-815-7

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