Cutaneous Neuroblastic and Ganglion Cell Proliferations

Abstract

Neuroblastoma is a malignant neoplasm of ­neural crest lineage, most often arising in the adrenal medulla, paraganglia, or sympathetic chain. Cutaneous neuroblastoma usually represents metastasis from a visceral primary. However, rare cutaneous neuroblastoma may develop de novo without an identifiable visceral tumor, possibly from heterotopic neural crest cells. Neuroblastoma represents the most primitive form in a family of neoplasms, which includes ganglioneuroma at the opposite, mature end of the spectrum.