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Mild Stress and Life Extension in Drosophila melanogaster

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Book cover Life-Span Extension

Part of the book series: Aging Medicine ((AGME))

Abstract

Being subjected to a mild stress can increase resistance to a stronger stress, but the idea of using mild stress to improve aging has not been systematically assessed until recent years. Several studies in the fly Drosophila melanogaster have shown that various mild stresses (hypergravity, heat, cold, irradiation) increase longevity; some mild stresses also increase the resistance to strong stresses (e.g., heat) and delay behavioral aging. The synthesis of the 70 kDa heat shock protein can explain the resistance to heat but not the increased longevity. The increased longevity induced by hypergravity is, however, not explained by the synthesis of the antioxidant enzymes superoxide dismutase and catalase. Therefore, for the time being, no explanation exists for the increased longevity and the delayed behavioral aging induced by a mild stress.

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Abbreviations

CAT:

Catalase

g:

Gravity

HG:

Hypergravity

Hsp:

Heat shock protein

SOD:

Superoxide dismutase

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Authors and Affiliations

  1. Université Paul-Sabatier Centre de Recherche sur la Cognition Animale, UMR CNRS 5169, Toulouse, cedex 9, 31062, France

    Éric Le Bourg

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  1. Éric Le Bourg
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Correspondence to Éric Le Bourg .

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Editors and Affiliations

  1. College of Medicine, Drexel University, North 15th St. 245, Philadelphia, 19102, U.S.A.

    Christian Sell

  2. College of Medicine, Drexel University, North 15th St. 245, Philadelphia, 19102, U.S.A.

    Antonello Lorenzini

  3. School of Medicine & Health Sciences, University of North Dakota, N. Columbia Road 501, Grand Forks, 58203, U.S.A.

    Holly M. Brown-Borg

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© 2009 Humana Press, a part of Springer Science+Business Media, LLC

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Bourg, É.L. (2009). Mild Stress and Life Extension in Drosophila melanogaster . In: Sell, C., Lorenzini, A., Brown-Borg, H. (eds) Life-Span Extension. Aging Medicine. Humana Press. https://doi.org/10.1007/978-1-60327-507-1_5

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  • DOI: https://doi.org/10.1007/978-1-60327-507-1_5

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-506-4

  • Online ISBN: 978-1-60327-507-1

  • eBook Packages: MedicineMedicine (R0)

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