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In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsy

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Bioimaging in Neurodegeneration

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Intrinsic optical signal (IOS) imaging is a technique for measuring changes in blood flow, metabolism, and cellular swelling associated with neuronal activity. The combined spatial and temporal resolution, in addition to the ability to sample large areas of cortex simultaneously, make it a powerful technique for brain mapping. IOS has only recently been applied systematically to the study of epilepsy. This chapter will explore the utility and feasibility of mapping interictal spikes, ictal onsets, offsets, and horizontal propagation using IOS imaging in acute and chronic animal models of epilepsy. The implementation of IOS imaging in the operating room during neurosurgical procedures will be discussed as well as technical challenges that currently restrict this translational work to a very few centers.

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Authors and Affiliations

  1. Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY

    Sonya Bahar PhD, Minah Suh PhD, Ashesh Mehta MD, PhD & Theodore H. Schwartz MD

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  1. Sonya Bahar PhD
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  2. Minah Suh PhD
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  3. Ashesh Mehta MD, PhD
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  4. Theodore H. Schwartz MD
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Editors and Affiliations

  1. Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY

    Patricia A. Broderick PhD

  2. Department of Neurology, New York University School of Medicine, New York, NY

    Patricia A. Broderick PhD  & Edwin H. Kolodny MD  & 

  3. NYU Comprehensive Epilepsy Center, New York, NY

    Patricia A. Broderick PhD

  4. Department of Chemistry and Physical Sciences, Pace University, Pleasantville, NY

    David N. Rahni PhD

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Bahar, S., Suh, M., Mehta, A., Schwartz, T.H. (2005). In Vivo Intrinsic Optical Signal Imaging of Neocortical Epilepsy. In: Broderick, P.A., Rahni, D.N., Kolodny, E.H. (eds) Bioimaging in Neurodegeneration. Contemporary Neuroscience. Humana Press. https://doi.org/10.1007/978-1-59259-888-5_14

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