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Radiofrequency Ablation of Colorectal Metastases to the Liver

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Colorectal Cancer

Part of the book series: Current Clinical Oncology ((CCO))

Abstract

The variety of techniques that have been developed and applied to treat metastatic colon cancer to the liver is a testament to the importance of this clinical problem and to the failure of any single technique to have provided a solution in this clinical situation. Radiofrequency thermal ablation (RFA) is one of the most recent techniques to be applied to the treatment of primary and metastatic disease in the liver. It can be categorized together with cryosurgical ablation and direction injection of alcohol, chemotherapeutics, or gene therapy vectors as a treatment that targets a specific area or region of the liver. These treatment strategies can be characterized as “subregional” regional therapy as opposed to vascular-based treatment that treat the entire liver. RFA is the opposite of cryoablation, as it uses heat generated by electrical current to directly destroy tissue, as opposed to cold temperatures to accomplish the same goal (1).

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References

  1. McGahan JP and Dodd GD. Radiofrequency ablation of the liver: current status. Am. J. Roentgenol., 176 (2001) 3–16.

    Article  Google Scholar 

  2. Giorgio A, Francica G, Tarantino L, and de Stefano G. Radiofrequency ablation of hepatocellular carcinomas lesions. Radiology, 218 (2001) 918–919.

    PubMed  CAS  Google Scholar 

  3. Siperstein AE and Gitominski A. History and technological aspects of radiofrequency thermoablation. Cancer J., 6 (2000) S293 - S303.

    Google Scholar 

  4. Goldberg SN, Solbiati L, Hahn PF, Cosman E, Conrad JE, Fogle R, et al. Large volume tissue ablation with radiofrequency by using a clustered, internally cooled electrode technique: laboratory and clinical experience in liver metastases. Radiology, 209 (1998) 371–379.

    PubMed  CAS  Google Scholar 

  5. Berber E, Flesher NL, and Siperstein AE. Initial clinical evaluation of the RITA 5-centimeter radiofrequency thermal ablation catheter in the treatment of liver tumors. Cancer J., 6 (2000) S319 - S329.

    Google Scholar 

  6. Scudamore C. Volumetric radiofrequency ablation: technical considerations. Cancer J., 6 (2000) S316 - S318.

    Google Scholar 

  7. Rossi S, Buscarini E, Garbagnati F, DiStasi M, Quaretti P, Rago M, et al. Percutaneous treatment of small hepatic tumors by an expandable RF needle electrode. Am. J. Roentgenol., 170 (1998) 1015–1022.

    Article  CAS  Google Scholar 

  8. Caturelli E. Percutaneous ablative therapies for small hepatocellular carcinoma: radiofrequency or percutaneous ethanol injection. Radiology, 216 (2000) 304–306.

    PubMed  CAS  Google Scholar 

  9. Heslin MJ, Medina-Franco H, Parker M, Vickers S, Aldrete J, and Urist MM. Colorectal hepatic metastases: resection, local ablation, and hepatic artery infusion pump are associated with prolonged survival. Arch. Surg., 136 (2001) 318–323.

    Article  PubMed  CAS  Google Scholar 

  10. Curley SA, Davidson BS, Fleming RY, Izzo F, Stephens LC, Tinkey P, et al. Laparoscopically guided bipolar radiofrequency ablation of areas of porcine liver. Surg. Endoscopy, 11 (1997) 729–733.

    Article  CAS  Google Scholar 

  11. Siperstein A, Garland A, Engle K, Rogers S, Berber E, String A, et al. Laparoscopic radiofrequency ablation of primary and metastatic liver tumors. Surg. Endosc., 14 (2000) 400–405.

    Article  PubMed  CAS  Google Scholar 

  12. Ravikumar TS, Kaleye R, and Kishinevsky A. Surgical ablative therapy of liver tumors. In Cancer: Principles & Practice of Oncology. 5th ed. Devita VT, Hellman S, and Rosenberg SA (eds.), Lippincott-Raven, New York, 2000, Vol. 14.

    Google Scholar 

  13. Rhim H and Dodd GD. Radiofrequency thermal ablation of liver tumors. J. Clin. Ultrasound, 27 (1999) 221–229.

    Article  PubMed  CAS  Google Scholar 

  14. Patterson EJ, Scudamore CH, Owen DA, Nagy AG, and Buczkowski AK. Radiofrequency ablation of porcine liver in vivo: effects of blood flow and treatment time on lesion size. Ann. Surg., 237 (1998) 559–565.

    Article  Google Scholar 

  15. Livraghi T, Goldberg SN, Monti F, Bizzini A, Lazzaroni S, Meloni F, et al. Saline-enhanced radiofrequency tissue ablation in the treatment of liver metastases. Radiology, 202 (1997) 205–210.

    PubMed  CAS  Google Scholar 

  16. Curley SA, Izzo F, Ellis LM, Vauthey JN, and Vallone P. Radiofrequency ablation of hepatocellular cancer in 110 patients with cirrhosis. Ann. Surg., 232 (2000) 381–391.

    Article  PubMed  CAS  Google Scholar 

  17. Rossi S, DiStasi M, Buscarini E, Quaretti P, Garbagnati F, Squassante L, et al. Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. Am. J. Roentgenol., 167 (1996) 759–768.

    Article  CAS  Google Scholar 

  18. Solbiati L, Goldberg SN, lerace T, Livraghi T, Meloni F, Dellanoce M, et al. Hepatic metastases: percutaneous radiofrequency ablation with cooled tip electrodes. Radiology, 205 (1997) 367–373.

    PubMed  CAS  Google Scholar 

  19. Solbiati L, Ierace T, Goldberg SN, Sironi S, Livraghi T, Fiocca R, et al. Percutaneous US-guided radiofrequency tissue albation of liver metastases: treatment and follow-up in 16 patients. Radiology, 202 (1997) 195–203.

    PubMed  CAS  Google Scholar 

  20. Jiao LR, Hansen PD, Havlik R, Mitry RR, Pignatelli M, and Habib N. Clinical short-term results of radiofrequency ablation in primary and secondary liver tumors. Am. J. Surg., 177 (1999) 303–306.

    Article  PubMed  CAS  Google Scholar 

  21. Berber E, Foroutani A, Garland AM, Rogers SJ, Engle KL, Ryan TL, et al. Use of CT Hounsfield unit density to identify ablated tumor after lapoaroscopic radiofrequency ablation of hepatic tumors. Surg. Endoscopy, 14 (2000) 799–803.

    Article  CAS  Google Scholar 

  22. Curley SA, Izzo F, Deirio P, Ellis LM, Granchi J, Vallone P, et al. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies. Ann. Surg., 230 (1999) 1–8.

    Article  PubMed  CAS  Google Scholar 

  23. Siperstein A, Garland A, Engle K, Rogers S, Berber E, Foroutani A, et al. Local recurrence after laparoscopie radiofrequency thermal ablation of hepatic tumors. Ann. Surg. Oncol., 7 (2000) 106–113.

    Article  PubMed  CAS  Google Scholar 

  24. Wood TF, Rose DM, Chung M, Allegra DP, Foshag LJ, and Bilchik AJ. Radiofrequency ablation of 231 unresectable hepatic tumors: indications, limitations, and complications. Ann. Surg. Oncol., 7 (2000) 593–600.

    PubMed  CAS  Google Scholar 

  25. deBaere T, Elias D, Dromain C, El Din MG, Kuoch V, Ducreux M, et al. Radiofrequency ablation of 100 hepatic metastases with a mean follow-up of more than 1 year. Am. J. Roentgenol., 175 (2000) 1619–1625.

    Article  CAS  Google Scholar 

  26. Pearson AS, Izzo F, Fleming D, Ellis LM, Delrio P, Roh MS, et al. Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. Am. J. Surg., 178 (1999) 592–599.

    Article  PubMed  CAS  Google Scholar 

  27. Sarantou T, Bilchik A, and Ramming KP. Complications of hepatic cryosurgery. Semin. Surg. Oncol., 14 (1998) 156–162.

    Article  PubMed  CAS  Google Scholar 

  28. Bilchik AJ, Wood TF, Allegra D, Tsioulias GJ, Chung M, Rose DM, et al. Cryosurgical ablation and radiofrequency ablation for unresectable hepatic malignant neoplasms: a proposed algorithm. Arch. Surg., 135 (2000) 657–662.

    Article  PubMed  CAS  Google Scholar 

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Fraker, D.L. (2002). Radiofrequency Ablation of Colorectal Metastases to the Liver. In: Saltz, L.B. (eds) Colorectal Cancer. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-160-2_24

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  • DOI: https://doi.org/10.1007/978-1-59259-160-2_24

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9670-3

  • Online ISBN: 978-1-59259-160-2

  • eBook Packages: Springer Book Archive

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