Abstract
In order to define the role of specific genes in vascular injury and repair, investigators have pursued mouse models of arterial injury applied to transgenic and knockout strains. However, arterial lumen size (i.e., carotid- and femoral-artery diameter <0.5 mm) precludes endovascular balloon injury as typically performed in the rat and larger animals. We have recently developed a novel form of mechanical carotid-artery dilation and complete endothelial denudation based on the air-drying rat model of Fishman et al. (1) This mouse model shares much in common with widely studied and characterized experimental models of vascular injury, and takes advantage of the genetic diversity of the murine system.
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Chen, Z., Rogers, C., Simon, D.I. (2001). Endothelial Denudation and Arterial Dilation in the Mouse. In: Simon, D.I., Rogers, C. (eds) Vascular Disease and Injury. Contemporary Cardiology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-003-2_7
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DOI: https://doi.org/10.1007/978-1-59259-003-2_7
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61737-169-1
Online ISBN: 978-1-59259-003-2
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