Abstract
The arteriovenous fistula (AVF) is the most common type of vascular access currently used for hemodialysis, but long-term outcomes remain poor in many patients; understanding the basic mechanisms of venous remodeling within the fistula environment is critical to improve our understanding of AVF maturation. In this chapter, we describe a method to create a murine aortocaval fistula that allows intraluminal drug delivery. This model reliably recapitulates human AVF maturation and therefore is a good consideration to study venous remodeling.
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Acknowledgments
This work was supported in part by the National Institutes of Health Grant R01-HL128406 and the Merit Review Award I01-BX002336 from the United States Department of Veterans Affairs Biomedical Laboratory Research and Development Program, as well as through the resources and the use of facilities at the Veterans Affairs Connecticut Healthcare System (West Haven, CT).
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Isaji, T., Dardik, A. (2018). The Mouse Aortocaval Fistula Model with Intraluminal Drug Delivery. In: Ishikawa, K. (eds) Experimental Models of Cardiovascular Diseases. Methods in Molecular Biology, vol 1816. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8597-5_21
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DOI: https://doi.org/10.1007/978-1-4939-8597-5_21
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