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Radiologically Imageable Nanoparticles

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Imaging and Visualization in The Modern Operating Room

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Abstract

Nanomaterials have been used industrially for several decades, yet it has only been in the last several years that they have been investigated for medical applications such as X-ray, computed tomography (CT), and magnetic resonance imaging (MRI). Engineered nanomaterials are highly attractive due the range of physical properties that can be selected based on core material and geometry. Through surface modification, nanomaterials can be made increasingly complex imparting a range of desired chemical and biological properties. In this chapter, we describe nanotechnologies that have been specifically engineered to yield significant improvements in diagnostic imaging including improved image contrast, longer imaging probe circulation time, reduced nephrotoxicity and patient discomfort, and the potential for multimodal imaging with a single administered dose. Despite the perceived promise, few nanomaterials have made their way into the clinical setting. Where possible we present here specific examples of approved and discontinued radiologically imageable nanomaterials.

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Author information

Authors and Affiliations

  1. Department of Chemical and Biological Engineering, University of Maine, 5737 Jenness Hall Rm 208, 04469, Orono, ME, USA

    Aileen L. Co BS & A. M. Sitarski BS

  2. Department of Chemical and Biological Engineering, University of Maine, 5737 Jenness Hall Rm 208C, Orono, ME, 04469, USA

    Jeremy L. Grant BA, MA

  3. Department of Chemical and Biological Engineering, University of Maine, 209 Jenness Hall, 04469, Orono, ME, USA

    Michael D. Mason PhD

Authors
  1. Aileen L. Co BS
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  2. A. M. Sitarski BS
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  3. Jeremy L. Grant BA, MA
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  4. Michael D. Mason PhD
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Corresponding author

Correspondence to Michael D. Mason PhD .

Editor information

Editors and Affiliations

  1. Department of Surgery, City of Hope National Medical Cente, Duarte, California, USA

    Yuman Fong

  2. General & Robotic Surgery, University of Illinois at Chicago Division of Minimally Invasive, Chicago, Illinois, USA

    Pier Cristoforo Giulianotti

  3. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Jason Lewis

  4. Department of Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands

    Bas Groot Koerkamp

  5. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Thomas Reiner

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Co, A., Sitarski, A., Grant, J., Mason, M. (2015). Radiologically Imageable Nanoparticles. In: Fong, Y., Giulianotti, P., Lewis, J., Groot Koerkamp, B., Reiner, T. (eds) Imaging and Visualization in The Modern Operating Room. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2326-7_6

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  • DOI: https://doi.org/10.1007/978-1-4939-2326-7_6

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  • Publisher Name: Springer, New York, NY

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  • Online ISBN: 978-1-4939-2326-7

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