Abstract
Vascular dementia or vascular cognitive impairment occurs as a result of persistently compromised blood flow to the brain and represents the second most common type of dementia after Alzheimer’s disease. In order to investigate its underlying mechanisms, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. This mouse model provides a unique platform to investigate the mechanisms of angiogenesis following chronic cerebral hypoperfusion and to explore potential drugs or cell therapies designed to enhance angiogenesis as a preclinical step toward developing novel treatments for dementia of vascular origin.
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Acknowledgement
We would like to express our gratitude to Dr. Ahmad Khundakar for insightful comments and editing. We would also like to thank Dr. Shibata, Dr. Nakaji, Dr. Fujita, Dr. Nishio, and Dr. Yamada (former members of Kyoto University) who have been involved in the establishment, characterization, and optimization of this animal model. This work was partially supported by Banyu Life Science Foundation International and was also supported by the Grant-in-Aid for Scientific Research (B) (M.I. No. 23390233) and by the Grant-in-Aid from the Ministry of Health, Labour and Welfare of Japan (M.I. No. 2450101-001).
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Ihara, M., Taguchi, A., Maki, T., Washida, K., Tomimoto, H. (2014). A Mouse Model of Chronic Cerebral Hypoperfusion Characterizing Features of Vascular Cognitive Impairment. In: Milner, R. (eds) Cerebral Angiogenesis. Methods in Molecular Biology, vol 1135. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-0320-7_8
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DOI: https://doi.org/10.1007/978-1-4939-0320-7_8
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4939-0319-1
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